WEEK 11&12

Question 1

Assay of Hydrogen Peroxide TITRANT

Answer 1

KMnO4

Question 2

Assay of Hydrogen Peroxide ANALYTE

Answer 2

H2O2 HYDROGEN PEROXIDE

Question 3

Assay of Hydrogen Peroxide INDICATOR

Answer 3

KMnO4

Question 4

Assay of Hydrogen Peroxide ENDPOINT

Answer 4

pink color

Question 5

Assay of Hydrogen Peroxide CHEMICAL REACTION

Answer 5

KMnO4 + H2O2 + H2SO4 — > MnSO4 + K2SO4 + O2 + H2O

Question 6

Assay of Hydrogen Peroxide AMOUNT OF ANALYTE

Answer 6

2mL

Question 7

MW OF H2O2

Answer 7

34

Question 8

mEq OF H2O2

Answer 8

0.017

Question 9

USP REQT FOR H2O2

Answer 9

2.5-3.5%

Question 10

%H2O2 =

Answer 10

Vol. of KMnO4 x N x (H2O2/2000)/
Vol. of H2O2 used

Question 11

H2O2 USP requirement per 100 ml is

Answer 11

nlt 2.5g and nmt 3.5 g

Question 12

Oxidizing agent, wound cleanser

Answer 12

H2O2

Question 13

DIRECT PERMANGANATE METHOD

Answer 13

H2O2
KBr

Question 14

INDIRECT PERMANGANATE METHOD

Answer 14

MALIC ACID IN CHERRY JUICE
TiO2
MnO2

Question 15

generally applies to the
products from plant and animal origin found in a raw
form.

Answer 15

crude drug

Question 16

outlines the different methods of analysis that
include physical and chemical tests. The
objective is to establish the identity and
conformity to set standards.
Pharmaceutical Analysis I Laboratory

Answer 16

USP <56> Articles of Botanical Origin

Question 17

allows more detailed examination of a drug and it
can be used to identify the organised drugs by their
known histological characters

Answer 17

Microscopic examination

Question 18

mostly used for qualitative evaluation of organised
crude drugs in entire and powdered forms.

Answer 18

Microscopic examination

Question 19

can be used to distinguish cellular structure

Answer 19

stains

Question 20

Lignin- phloroglucinol and concentrated hydrochloric
acid give

Answer 20

red stain

Question 21

Mucilage - stained

Answer 21

pink with rhuthenium red

Question 22

TLC
* Principle :

Answer 22

Adsorption

Question 23

useful to analyse Alkaloids, Glycosides like all bio-
constituents

Answer 23

TLC

Question 24

The parts of the organ or organs other than those
parts of drugs mentioned in the definition and
description of the drug are known as

Answer 24

Foreign matter

Question 25

Amount of volatile matter of any kind that is driven off at 110-120 DEGREES CELSIUS.

Answer 25

Loss on Drying

Question 26

Sodium Chloride * USP Requirement:

Answer 26

NMT 0.25 % loss of weight

Question 27

Loss of weight of sample =

Answer 27

weight of sample – weight of dried sample

Question 28

%Loss on drying =

Answer 28

loss of weight of sample x 100/ Weight of sample

Question 29

can be determined by heating the drug at 150⁰C in an oven to a constant weight and calculating the loss of weight

Answer 29

Moisture content

Question 30

Methods for the determination of moisture content

Answer 30

1. Gravimetric method (w,v) 2. Gravimetric method (e) 3. Azeotropic method or toluene distillation 4. Titrimetric method or karl fischer method 5. Dew point method 6. Electrolytic hygrometric

Question 31

1 mL of the reagent is equivalent to approximately _ milligrams of water

Answer 31

5

Question 32

Primary standard KARL FISHER REAGENT:

Answer 32

Na Tartrate

Question 33

react with water to SO3

Answer 33

Sulfur dioxide

Question 34

prevent reversibility of rxn

Answer 34

Pyridine

Question 35

prevent pyridine-S complex

Answer 35

Anhydrous methanol

Question 36

rx with HI

Answer 36

Iodine

Question 37

Azeotropic Method/ Toluene Distillation Method Solvent:

Answer 37

Toluene and xylene

Question 38

Method of choice for chemical samples (1-2 grams), ✓biologics

Answer 38

Gravimetric Method/ Drying/Thermal Method

Question 39

the extracts obtained by exhausting crude drugs with different solvents are approximate measures of their chemical constituents

Answer 39

Extractives

Question 40

Water soluble extractive

Answer 40

glycosides, tannins, mucilage

Question 41

Alcohol- soluble extractive

Answer 41

tannins, glycosides, resins

Question 42

ether-soluble extractives

Answer 42

volatile constituents and fats

Question 43

is the residue left after incineration

Answer 43

Total Ash

Question 44

It may also include inorganic matter added for the purpose of ADULTERATION.

Answer 44

TOTAL ASH

Question 45

This may serve as basis for judging the IDENTITY AND CLEANLINESS of a drug

Answer 45

Total Ash

Question 46

useful for detecting low grade products, exhausted drugs, and excess of sandy or earthy matter

Answer 46

Total Ash

Question 47

_______ *For determining ash content of expensive chemicals. Igniting the sample to dull redness and RESIDUE SHOULD NOT EXCEED _____

Answer 47

RESIDUE ON IGNITION 500 ug

Question 48

USP requirement: * Total ash : NMT _ * Acid insoluble ash : NMT _

Answer 48

5 % 1%

Question 49

%Total Ash =

Answer 49

weight of ash x 100/ wt. of sample

Question 50

consists almost entirely of silica derived from the soil adhering to the drug.

Answer 50

Acid-insoluble ash

Question 51

Used for the determination of earthy matter present on roots, rhizomes, and also on the leaves, Crude drugs contain calcium oxalate crystals the amount may varies depending on the environmental conditions.

Answer 51

Acid-insoluble ash

Question 52

Part of the total ash that is insoluble with diluted hydrochloric acid

Answer 52

Acid-insoluble ash

Question 53

% Acid-insoluble ash =

Answer 53

wt of the acid-insoluble ash x 100/ wt of the sample

Question 54

Calcium carbonate- calcium oxalate

Answer 54

825 C

Question 55

Calcium phosphate – calcium pyrophosphate

Answer 55

1550 C

Question 56

Lithium carbonate – lithium oxide

Answer 56

600 C

Question 57

Potassium chloride – sublimes

Answer 57

1500 C

Question 58

is the process of removing extraneous matter, such as other parts of the plant, dirt, and added adulterants

Answer 58

Garbling