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WEEK 11 - MULTIPLE SCLEROSIS (MS) Flashcards

(11 cards)

1
Q

multiple sclerosis (MS)

A

autoimmune disease of CNS - accelerated cortical volume loss

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2
Q

radiologically isolated syndromes (RIS)

A

Where white matter lesions are apparent that fulfill the criteria for MS, but there is no recorded clinical attack

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3
Q

Clinically isolated syndromes (CIS)

A

the first episode of neurological systems indicative of inflammation and/or demyelination attack that lasts for 24 hours or more and usually only effects one area

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4
Q

Relapsing-Remitting MS (RRMS)

A

Periods of attack followed by recovery (remission of symptoms), usually once or twice a year

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5
Q

Secondary Progressive MS (SPMS)

A

RRMS can become diagnosis of SPMS when symptoms change from a relapse-remitting pattern to a situation where the degree of disability progressively worsens over time

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6
Q

Primary Progressive MS (PPMS)

A

About 10-15% of cases of MS. No observation of RR phase, but progressive functional decline

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7
Q

neuropathology of MS

A

dysfunction of immune system, chronic inflammation, neurodegeneration

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8
Q

factors associated with pathogenesis of MS

A

thyroid hormone, vitamin D, sex hormones, mitochondrial dysfunction and oxidative stress

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9
Q

assessments of cognitive changes in MS

A

Brief Repeatable Neuropsychological Battery (BRNB), Minimal Assessment of Cognitive Function (MASCS) and MS Neuropsychological Screening Questionnaire (MSNQ)

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10
Q

treatment and management of MS functions

A

control attacks, prevent or slow progression, address symptoms, manage secondary complications

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11
Q

treatment approaches of MS

A

mitochondrial-protective strategies, anti-inflammatory agents, microglia inhibitors, re-myelination therapies, stem cell transplantation

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