WEEK 11 - MULTIPLE SCLEROSIS (MS) Flashcards
(11 cards)
multiple sclerosis (MS)
autoimmune disease of CNS - accelerated cortical volume loss
radiologically isolated syndromes (RIS)
Where white matter lesions are apparent that fulfill the criteria for MS, but there is no recorded clinical attack
Clinically isolated syndromes (CIS)
the first episode of neurological systems indicative of inflammation and/or demyelination attack that lasts for 24 hours or more and usually only effects one area
Relapsing-Remitting MS (RRMS)
Periods of attack followed by recovery (remission of symptoms), usually once or twice a year
Secondary Progressive MS (SPMS)
RRMS can become diagnosis of SPMS when symptoms change from a relapse-remitting pattern to a situation where the degree of disability progressively worsens over time
Primary Progressive MS (PPMS)
About 10-15% of cases of MS. No observation of RR phase, but progressive functional decline
neuropathology of MS
dysfunction of immune system, chronic inflammation, neurodegeneration
factors associated with pathogenesis of MS
thyroid hormone, vitamin D, sex hormones, mitochondrial dysfunction and oxidative stress
assessments of cognitive changes in MS
Brief Repeatable Neuropsychological Battery (BRNB), Minimal Assessment of Cognitive Function (MASCS) and MS Neuropsychological Screening Questionnaire (MSNQ)
treatment and management of MS functions
control attacks, prevent or slow progression, address symptoms, manage secondary complications
treatment approaches of MS
mitochondrial-protective strategies, anti-inflammatory agents, microglia inhibitors, re-myelination therapies, stem cell transplantation