Week 14 Flashcards
Hematology (31 cards)
Blood cell production is
Hematopoiesis
undeveloped, precursor cells in the bone marrow
Pluripotent Stem Cells
Substance found in the middle of the center of bones; hematopoiesis takes place here
Bone Marrow
Immature precursor cells for each WBC line
Blast Cells
A rise in WBC count above 11000/mcl
Leukocytosis
A decrease in WBC below 400/mcl
Leukopenia
These cells are first responsers to an infection, stress, or inflammation. Part of the innate immunity
Neutrophils
A lack of sufficient number of neutrophils
Neutropenia
A lab test that identifies the amount of each type white blood cells and immature blood cells
CBC w/ Diff
A large bore needle that extracts cells from the hip bone to examine the precursor cells in various stages of maturation
Bone Marrow Aspiration
A sequence of coagulation factors that form fibrin strands that strength a platelet plug to form a clot
Coagulation Cascade
Insufficient delivery of oxygen to the tissues by inadequate number of mature, healthy RBCs
Anemia
Immature RBCs. Should remain in the bone marrow until maturity
Reticulocytes
Destruction of RBCs
Hemolysis
Misshapen RBCs become trapped and block blood flow, leading to ischemia in different organs
Vas-occlusive Crisis
The physiologic process that stops bleeding at the site of an injury
Hemostasis
Low platelets, which can cause bleeding
Thrombocytopenia
Difference between sickle cell disease and sickle cell trait
- having the trait doesn’t mean you have the disease
- men more likely to have disease
What is vaso-occlusive crisis and what could trigger it to occur
- sickle cell clot> leads to ischemia/ death(cell/organ)
- emergent situation
- infection, stress, dehydration
The major steps of hemostasis
- vasoconstriction
- Development of platelet plug
- coagulation
Fibrinogen coverts to what?
Fibrin
Acute Leukemias deal with what type of cells?
Blast (immature) cells
Chronic leukemias deal with what type of cells?
Mature cells
Which of the following white blood cell (WBC) levels would indicate that a patient has leukocytosis?
1. 1200 cells per microliter
2. 1800 cells per microliter
3. 5000 cells per microliter
4. 12,000 cells per microliter
- 12000/mcl