Week 3: Celiac Disease Flashcards by Jay Sandoval

Q

What is celiac disease?

A

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Q

How is the autoimmune response triggered in celiac disease

A

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Q

HLA types common in Celiac disease

A

HLA DQ2

HLA DQ8

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Q

Different serological types of celiac disease

A

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Q

Question

A

D. Submucosa

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Q

Question

A

B. Lamina Propria

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Q

What is the main difference between small intestinal mucosa and colonic mucosa?

A

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Q

Differences in function of small intestine and colon

A

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Q

Describe histologic features of small intestine

A

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Q

Describe histologic features of the large intestine

A

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Q

Question

A

D. Goblet cell

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Q

Villi compared to crypts

A

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Q

Celiac Disease Diagnostic criteria

A

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Q

Who diagnoses Celiac disease

A

E.

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Q

Pathologic histologic features of celiac disease

A

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Q

Small intestinal CD3 stain

A

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Q

Question

A

A. the one on the left

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Q

Histologic features of celiac disease

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A

Q

What is the preferred biopsy location for celiac disease

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A

Q

Describe histological features of 1st and 2nd portions of duodenum

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A

1st is more sensitive for celiac has a lot of Brunners glands
2nd part is more specific for celiac

Q

Mucosal damage and symptomology or serology

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A

Q

MARSH Classifications

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A

Q

Describe these features

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A

Q

Compare celiac histology to normal small intestine

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A

Compare celiac histology to colon

Question

Anti-tTG levels can be elevated in?

Other serological tests for celiac disease

HLA testing benefits for celiac disease

Assume a different scenario

No, lack of blah blah

Are IELs and villous blunting pathognomonic of celiac

Differentials of celiac disease

How common are increased IELs in duodenal biopsies?

What is the best initial test for celiac disease?

Anti-tTG test

Summary of celiac disease

Algorithm of celiac disease testing

Question

Looks normal B. Villi are the right height

Question

too many lymphocytes in the villus tip

CD3 stain

way too many lymphocytes at the villus tips

Question Is this celiac disease?

C Maybe poster child for gluten diet restriction

Describe

stomach antral mucosa 2x lymphoplasmacytic infiltrate along superficial aspect of antral mucosa

Diagnosis

H. pylori

Celiac disease complications

What is refractory celiac disease?