Week 5 Flashcards

1
Q

What is the endocrine system?

A

A collection of glands and organs that release hormones into the circulatory system to regulate physiological functions such as:
- Digestion
- Metabolism
- Sleep–wake cycles
- Development
- Growth

The endocrine system plays a critical role in maintaining various bodily functions.

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2
Q

How do endocrine glands produce hormones?

A

In response to different stimuli:
- Hormone signals
- Environmental signals
- Nervous system signals

These stimuli trigger the production and release of hormones into the bloodstream.

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3
Q

What are the three major components of the endocrine system?

A

They are:
- Glands
- Hormones
- Receptors

Each component plays a crucial role in hormone regulation and function.

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4
Q

What is the function of the hypothalamus?

A

Controls homeostasis and regulates the release of hormones.

The hypothalamus exerts direct influence over the autonomic nervous system.

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5
Q

Why is the pituitary gland called the master gland?

A

Because it secretes many important hormones and regulates the activity of other hormone-secreting glands.

The pituitary gland plays a significant role in various biological processes.

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6
Q

What hormones are secreted by the posterior pituitary?

A

Secretes:
- Oxytocin
- Antidiuretic hormone (ADH)

These hormones are produced in the hypothalamus and released from the posterior pituitary.

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7
Q

What hormones does the anterior pituitary synthesize and secrete?

A

Synthesizes and secretes:
- Growth hormone
- Prolactin
- Follicle stimulating hormone (FSH)
- Luteinising hormone (LH)
- Thyroid stimulating hormone
- Adrenocorticotropic hormone

Each hormone has specific roles in regulating growth, reproduction, and metabolism.

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8
Q

What is the role of the thyroid gland?

A

Key role in:
- Growth
- Development
- Energy metabolism

The thyroid secretes hormones that affect virtually every tissue in the body.

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9
Q

What hormones are secreted by the thyroid gland?

A

Secretes:
- Thyroxine (T4)
- Triiodothyronine (T3)

T4 is converted into its active form, T3, in the body.

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10
Q

What is the function of the parathyroid glands?

A

Secrete parathyroid hormone, which regulates calcium, magnesium, and phosphate levels in the blood.

This regulation is crucial for maintaining bone health and metabolic functions.

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11
Q

What hormones are produced by the adrenal glands?

A

Produce:
- Cortisol
- Aldosterone
- Adrenaline
- Noradrenaline

These hormones are involved in stress response, metabolism, and electrolyte balance.

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12
Q

What is the role of the pancreas in the endocrine system?

A

Secretes:
- Insulin
- Glucagon

These hormones regulate blood glucose levels.

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13
Q

What are gonads and their function?

A

The ovaries in females and testis in males that secrete sex hormones such as:
- Oestrogen
- Testosterone

These hormones control the growth and function of reproductive organs.

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14
Q

How does the endocrine system differ from the nervous system?

A

Endocrine system:
- Acts via hormones released into the blood
- Slow response time (seconds to days)
- Long-lasting effects

Nervous system:
- Acts via electrochemical impulses
- Rapid response time (milliseconds)
- Short duration responses

These differences highlight the distinct roles each system plays in body regulation.

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15
Q

What defines a target cell in the endocrine system?

A

A cell that has a specific receptor for a particular hormone.

Only target cells respond to their specific hormones, leading to characteristic physiological changes.

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16
Q

What are the three major types of stimuli that control hormone release?

A

They are:
- Humoral stimuli
- Neural stimuli
- Hormonal stimuli

Each type of stimulus triggers hormone synthesis and release in different ways.

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17
Q

What is humoral stimuli?

A

Stimulated by factors in the blood, such as ion and nutrient concentrations.

For example, low calcium levels stimulate parathyroid hormone release.

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18
Q

What is neural stimuli?

A

Hormone secretion regulated by the central nervous system.

The hypothalamus plays a key role in controlling pituitary hormones through neural stimuli.

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19
Q

What is hormonal stimuli?

A

Release of hormones in response to hormones produced by other endocrine organs.

This creates a cascade effect where one hormone stimulates the release of another.

20
Q

What role do transport proteins play in the endocrine system?

A

Transport proteins carry lipid-soluble hormones in the bloodstream and help regulate their circulation.

They protect hormones from degradation and ensure even distribution within the body.

21
Q

What is the biological half-life of a hormone?

A

The time it takes for half of a hormone’s concentration to be degraded or removed from the bloodstream.

Hormones with shorter half-lives require more frequent secretion to maintain activity.

22
Q

What factors influence hormone activity?

A

Factors include:
- Concentration of the hormone
- Biological half-life
- Receptor numbers and affinity
- Influence from other hormones

These factors determine how effectively a hormone can exert its effects on target cells.

23
Q

What is the permissive effect of hormones?

A

When one hormone enhances the responsiveness of a target organ to another hormone.

For example, estrogen increases the uterus’s responsiveness to progesterone.

24
Q

What are antagonistic hormones?

A

Hormones that act to return body conditions to acceptable limits from opposite extremes.

An example is insulin and glucagon in regulating blood glucose levels.

25
What is the synergistic effect of hormones?
Occurs when two or more hormones work together to produce a greater effect. ## Footnote This can amplify the physiological response beyond what either hormone could achieve alone.
26
What hormone is secreted by alpha cells when blood glucose concentration drops?
Glucagon ## Footnote Glucagon is secreted during conditions like exercise when blood glucose levels are low.
27
What does glucagon stimulate the liver to release?
Glucose ## Footnote Glucose release originates from the breakdown of glycogen.
28
What alternative energy sources does glucagon stimulate the production of?
Ketone bodies ## Footnote Ketone bodies are produced from amino acids and fatty acids.
29
What mechanism stops glucagon secretion when blood glucose levels normalize?
Negative feedback ## Footnote Glucagon secretion is discontinued when blood glucose levels return to normal.
30
What is the synergistic effect of hormones?
When two or more hormones combine to produce effects greater than the sum of their individual effects ## Footnote Synergistic effects can be additive or complementary.
31
Give an example of an additive effect of hormones.
The action of epinephrine and norepinephrine on the heart ## Footnote Each hormone separately increases cardiac rate, and together they stimulate an even greater increase.
32
What is an example of a complementary effect of hormones?
The synergistic action of testosterone and follicle-stimulating hormone (FSH) in sperm production ## Footnote Each hormone stimulates different stages of spermatogenesis.
33
What is required for the mammary glands to produce and secrete milk?
The synergistic action of many hormones ## Footnote Hormones involved include estrogen, cortisol, prolactin, and oxytocin.
34
From what are steroid hormones derived?
Cholesterol ## Footnote Steroid hormones are formed through a series of chemical reactions that modify cholesterol.
35
What property allows steroid hormones to pass through the plasma membrane of cells?
Lipid-solubility ## Footnote This property is due to their chemical structure.
36
What types of carriers do lipid-soluble steroids bind to in the bloodstream?
Two types: - Specialized carriers - Plasma protein albumin ## Footnote Specialized carriers bind specific steroid hormones, while albumin non-selectively binds many lipid-soluble hormones.
37
What happens when steroid hormones enter a cell?
They interact with receptors in the cytoplasm or nucleus ## Footnote This triggers their effects within the cell.
38
What is the role of the hormone-receptor complex?
Acts as a transcription factor ## Footnote It binds to the hormone response element on DNA.
39
What is produced when a gene is activated by the hormone-receptor complex?
Messenger RNA (mRNA) ## Footnote mRNA is then translated into a protein.
40
What type of hormones are amino acid-based hormones?
Water-soluble and lipid-insoluble ## Footnote This affects how they interact with cell receptors.
41
Where do amino acid-based hormones bind in the cell?
To receptors embedded in the plasma membrane ## Footnote This is due to their water-solubility.
42
What molecule is displaced when an amino acid-based hormone binds to its receptor?
Guanosine diphosphate (GDP) ## Footnote This displacement leads to the activation of G proteins.
43
What does the activated G protein bind to?
Guanosine triphosphate (GTP) ## Footnote GTP is a high-energy molecule that activates the G protein.
44
What enzyme does the activated G protein bind to and activate?
Adenylyl cyclase ## Footnote This enzyme converts ATP into cyclic adenosine monophosphate (cAMP).
45
What is the role of cAMP in the cell?
Acts as a second messenger ## Footnote cAMP activates intracellular enzymes that lead to cellular responses.