Week 7 Flashcards

1
Q

What is the digestive system?

A

The digestive system is essential for converting food into energy and materials for body cells.

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2
Q

What are the functions of the digestive system?

A
  • takes in food
  • breaks food down into nutrient molecules
  • absorbs nutrient molecules into the bloodstream
  • eliminates indigestible remains from the body
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3
Q

What are the two main components of the digestive system?

A

· Alimentary Canal (Gastrointestinal or GI Tract):
- Continuous muscular tube running from the mouth to the anus
- Includes the mouth, pharynx, esophagus, stomach, small intestine, and large intestine
- The inside of the GI tract is technically considered outside the body, as it is open to the external environment at both ends
· Main functions:
- Digests food by breaking it down into smaller fragments
- Absorbs the digested fragments into the bloodstream
· Accessory Digestive Organs:
- Help in the process of digestion
- Include the teeth, tongue, salivary glands, liver, gallbladder, and pancreas
- Involved in mechanical processing and secretion of digestive enzymes and fluids

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4
Q

What is the digestive tract?

A

a food disassembly line, in which food becomes less complex at each step of processing.

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5
Q

What are the six activities involved with the processing of food?

A

Ingestion, propulsion, mechanical digestion, chemical digestion, absorption, defecation

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6
Q

What is ingestion?

A

· the process of taking food or substances into the mouth to begin the digestive process.
· This initial step involves chewing (mastication) and swallowing (deglutition), leading to the passage of food into the digestive tract, where further breakdown and absorption occur.

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7
Q

What is propulsion?

A

Propulsion refers to the movement of food and other substances through the digestive tract. It is primarily driven by peristalsis, which involves rhythmic, wave-like contractions of smooth muscles in the GI tract walls. These contractions:
- Propel contents forward
- Mix and churn food
- Are most prominent in the esophagus and stomach
- Work like squeezing toothpaste from a tub

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8
Q

What is mechanical digestion?

A

Mechanical digestion is the physical breakdown of food into smaller particles, making it easier for enzymes to act and aiding nutrient absorption. It:

  • Increases surface area for digestive enzymes
  • Supports efficient digestion and absorption
    Where it occurs:
  • Mouth:
    Begins with mastication (chewing)
    Teeth break food into smaller fragments
  • Stomach:
    Muscular contractions churn and mix food with gastric juices
    Forms chyme, a semi-liquid mixture
  • Small intestine:
    Peristalsis moves and mixes chyme
    Segmentation contractions slosh contents back and forth
    Enhances mixing in the small and large intestines
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9
Q

What is chemical digestion

A

Chemical digestion is the breakdown of complex food molecules into simpler molecules using enzymes and digestive substances. It:

Complements mechanical digestion
Breaks food into molecules small enough for absorption
Allows nutrients to be used for energy, growth, and repair
Where it occurs:

Mouth:
Begins with enzymes like amylase
Starts digestion of carbohydrates into simple sugars
Stomach:
Hydrochloric acid and pepsin break down proteins into amino acids
Small intestine (main site):
Enzymes from pancreas and bile from liver aid digestion
Carbohydrates → simple sugars
Proteins → amino acids
Fats → fatty acids and glycerol
Nutrients are absorbed through intestinal lining into the bloodstream

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10
Q

What is absorption?

A

Absorption is the process of taking up digested nutrients, water, and electrolytes from the GI tract into the bloodstream or lymph for distribution throughout the body.

Where it occurs:

Small intestine (main site – ~90%):
Villi and microvilli increase surface area
Nutrients absorbed by:
→ Diffusion
→ Facilitated diffusion
→ Active transport
Absorbed nutrients include:
→ Glucose
→ Amino acids
→ Fatty acids and glycerol
Large intestine:
Absorbs remaining water and electrolytes
Helps maintain fluid and electrolyte balance

Purpose:

Nutrients are transported to body cells for
→ Energy production
→ Growth
→ Repair
Indigestible material continues and is excreted as feces

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11
Q

What is defecation?

A

Defecation is the process of expelling waste from the body through the anus. It removes indigestible materials, bacteria, cellular waste, and excess water, helping maintain digestive health.

How it works:

After digestion and absorption in the small intestine, leftovers enter the large intestine
Water is absorbed, and material is formed into faeces
Faeces include:
→ Undigested food
→ Bacteria
→ Cellular debris
→ Water
In the rectum:

Faeces accumulate, triggering nerve signals
Internal anal sphincter relaxes (involuntary)
Faeces move into the anal canal
External anal sphincter (voluntary) controls release
Muscles of rectum and abdomen contract to assist expulsion

Purpose:

Removes waste
Supports digestive system balance and health

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12
Q

What are the digestive reflexes and how do they work?

A

Digestive reflexes are responses triggered by specialized receptors in the GI tract that detect:

  • Stretching of the walls
  • Chemical composition
  • Presence of nutrients or irritants

These reflexes can:
- Activate/inhibit digestive glands (release juices or hormones)
- Stimulate smooth muscle to mix and move contents through the tract

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13
Q

How are hormones secreted in the digestive system?

A

Hormones are secreted by endocrine cells in the stomach and small intestine lining.

  • Stimuli cause these cells to release hormones into the interstitial fluid
  • Hormones enter the bloodstream and travel to target cells
  • They regulate digestive processes like secretion and motility
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14
Q

What are key digestive hormones and their functions?

A

Several hormones regulate digestion:

Gastrin – stimulates gastric acid secretion
CCK (Cholecystokinin) – stimulates bile release and pancreatic enzyme secretion
They help regulate:

Enzyme and fluid secretion
GI tract motility
Coordination of digestion and nutrient absorption

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15
Q

What is the mouth (oral cavity) and its function?

A

The oral cavity is lined with squamous epithelium, which helps it withstand friction from eating.
- The gums, hard palate, and back of the tongue are slightly keratinized for extra protection.
- Function: Receives food, begins mechanical digestion (chewing), and starts chemical digestion (salivary enzymes).

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16
Q

What role do the lips and cheeks play in digestion?

A

The lips and cheeks help keep food between the teeth during chewing, facilitating, proper mastication and making it easier to break down food.

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17
Q

What is the role of the tongue in digestion?

A

The tongue:
- Is an accessory organ of digestion.
- Contains taste buds in papillae.
- Grips and repositions food during chewing.
- Mixes food with saliva to form a bolus.
- Initiates swallowing by pushing the bolus into the pharynx.
- Composed of skeletal muscle and assists in speech, especially in the formation of consonants.

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18
Q

What are the functions of teeth in digestion?

A

Teeth:
- Embedded in the gums.
- Used for mastication (chewing), grinding food to break it into smaller pieces.
- Help process food for easier swallowing and digestion.

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19
Q

What is the structure and function of the palate?

A

The palate forms the roof of the mouth and consists of two parts:
- Hard palate: Provides a rigid surface for food to be forced against while chewing. Slightly corrugated to create friction with the tongue.
- Soft palate: Closes off the nasopharynx during swallowing to prevent food from entering the nasal cavity.

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20
Q

What is deglutination (swallowing)?

A

Deglutination refers to swallowing. It takes:
- About 8 seconds for solid food to reach the stomach.
- 1 to 2 seconds for liquids to reach the stomach.

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21
Q

What is ingestion in the digestive process?

A

Ingestion is the intake of food.
- It involves mechanical digestion (chewing) by the teeth and chemical digestion via enzymes like salivary amylase and lingual lipase.
- Ingestion is partly voluntary and partly reflexive.

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22
Q

What is the buccal phase of swallowing?

A

The buccal phase is the propulsion of the bolus into the oropharynx and then the laryngopharynx.
- It involves multi-layered epithelial cells that protect the pharynx and skeletal muscles that contract to propel food.
- The nasopharynx has no digestive role.

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23
Q

What occurs during the pharyngeal phase of swallowing?

A

During the pharyngeal phase:

The food moves through the laryngopharynx, and the epiglottis closes the larynx to prevent food from entering the respiratory system.
Peristalsis moves the bolus from the pharynx to the esophagus involuntarily.

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24
Q

What happens during the esophageal phase of swallowing?

A

In the esophageal phase:
- The lower esophageal sphincter opens to allow the bolus into the stomach.
- The bolus is moved down the esophagus by peristalsis, which is involuntary.

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25
What is the role of gastrin in the stomach?
Gastrin is a hormone that stimulates gastric secretion, helping promote digestion in the stomach
26
What is the enterogastric reflex?
The enterogastric reflex inhibits gastric secretion when the small intestine is full or irritated, helping regulate the pace of digestion.
27
28
How does peristalsis function in the stomach?
Peristalsis begins near the gastroesophageal sphincter and moves toward the pyloric sphincter, with contractions growing stronger to mix and push food toward the small intestine.
29
What is retropulsion in the stomach?
Retropulsion occurs at the pyloric valve, involving a back-and-forth motion that: - Breaks food into smaller particles - Mixes food with gastric juices - Controls the rate of gastric emptying into the duodenum
30
What factors affect gastric emptying?
The stomach usually empties within four hours after a meal. - Liquids and carbohydrates empty faster - Fats and proteins take longer to digest and delay emptying
31
What is the digestive function of the liver?
The liver produces bile, a substance essential for fat digestion and absorption.
32
What is bile and what does it do?
Bile is a yellow–green fluid that contains bile salts and phospholipids. - Produced by the liver (about 900 mL/day) - Stored and concentrated in the gallbladder - Emulsifies fats and helps absorb fat and cholesterol
33
What is the digestive role of the pancreas?
The pancreas produces pancreatic juice, an exocrine secretion that contains enzymes to digest carbohydrates, fats, proteins, and nucleic acids.
34
What enzymes are found in pancreatic juice?
Pancreatic juice contains: - Amylases – break down carbohydrates - Lipases – break down fats - Proteases – break down proteins - Nucleases – break down nucleic acids
35
What is the composition and function of pancreatic juice?
Pancreatic juice (up to 1.5 L/day) consists of water, enzymes, and electrolytes. - Alkaline bicarbonate neutralizes stomach acid - Delivered to the duodenum to aid digestion
36
What is the gastro-ileal reflex and its function?
The gastro-ileal reflex is a long reflex triggered by stomach activity. It: - Increases segmentation in the ileum - Relaxes the ileocecal sphincter, allowing chyme into the large intestine - Prepares the small intestine for new food
37
What role does gastrin play in the gastro-ileal reflex?
Gastrin, released by the stomach: - Increases ileum motility - Relaxes the ileocecal sphincter, aiding movement of chyme to the large intestine
38
How is regurgitation of chyme into the ileum prevented?
Once chyme enters the large intestine, backward pressure: - Closes the ileocecal valve - Prevents regurgitation into the small intestine
39
What is the purpose of the gastro-ileal reflex?
It: - Clears out remnants of the previous meal - Prepares the small intestine for the next wave of food
40
What triggers the defecation reflex in the large intestine?
Parasympathetic motor signals stimulate: Contraction of the sigmoid colon and rectum Relaxation of the internal anal sphincter (involuntary)
41
How is voluntary control involved in defecation?
- If convenient, voluntary motor neurons are inhibited, allowing the external anal sphincter to relax and defecation to occur - If not, the reflex subsides, the rectal wall relaxes, and the urge fades
42
What happens if defecation is delayed?
If defecation is delayed: - Reflex contractions stop temporarily - The urge returns with the next mass movement, restarting the cycle until defecation occurs
43
Where and how does nucleic acid digestion begin?
Nucleic acid digestion occurs entirely in the small intestine. - Pancreatic nucleases (DNase and RNase) break down DNA and RNA into nucleotide monomers - Each nucleotide contains a nitrogenous base, pentose sugar, and phosphate group
44
What happens to nucleotides at the brush border?
Brush border enzymes on the microvilli further break down nucleotides into: - Nitrogenous bases (adenine, thymine, cytosine, guanine, uracil) - Pentose sugars (deoxyribose, ribose) - Phosphate ions
45
How are nucleic acid components absorbed and used?
Free bases, sugars, and phosphate ions are absorbed by intestinal cells, then enter the bloodstream. They are reused for: - Nucleic acid synthesis - Cell repair and growth
46
47
What are the main functions of saliva?
Saliva functions include: Lubrication – cleans/moistens mouth, dissolves food for tasting Digestion – salivary amylase breaks down carbohydrates Buffering – maintains pH ~7 to limit microbial growth Immune defense – contains antibodies and lysozymes
48
What are the two main types of saliva and their roles?
Serous (watery): Rich in amylase, water, electrolytes Aids in digestion and lubrication Mucous (viscous): Rich in mucin proteins Protects, coats, and lubricates oral surfaces Helps form the bolus
49
What is the submandibular gland and what does it secrete?
- Produces about 70% of saliva - Located beneath the jaw Secretes a mix of serous and mucous saliva - Delivers saliva via the submandibular duct
50
What is the parotid gland and its function?
- Produces about 25% of saliva - Largest salivary gland, located near the ear - Secretes mainly serous saliva - Rich in amylase for carbohydrate digestion - Uses the Stensen’s (parotid) duct
51
What is the sublingual gland and what type of saliva does it produce?
- Produces about 5% of saliva - Located beneath the tongue - Secretes mainly mucous saliva - Aids in lubrication and binding food - Uses the ducts of Rivinus
52
How does mucous saliva aid in swallowing?
Mucous saliva contains mucin, which: - Coats and protects oral tissues - Helps form the bolus - Enables smooth passage of food down the esophagus
53
What is metabolism, and what are its two main components?
Metabolism is the sum of all biochemical reactions in the body. - Anabolism: builds molecules - Catabolism: breaks down molecules
54
What are the two main nutritional states of the body?
1. Absorptive (fed) state – during and ~4 hours after eating 2. Postabsorptive (fasting) state – when the GI tract is empty Metabolic control mechanisms keep nutrient levels stable between these states.
55
What are nutrient pools and which tissues regulate them?
Nutrient pools (amino acids, carbs, fats) are interconvertible. - Regulated by the liver, adipose tissue, and skeletal muscle
56
What happens to glucose in the absorptive state? Glucose is: Released into the bloodstream Stored as glycogen in liver/muscles Converted to fat for long-term storage
57
What is the fate of fats and amino acids in the absorptive state?
- Fats: used for energy or stored in adipose tissue - Amino acids: used for protein synthesis; excess converted to keto acids, fat, or glycogen
58
What is insulin’s role in the absorptive state?
Insulin: - Increases glucose uptake (via GLUT4) - Promotes amino acid transport and protein synthesis - Stimulates glycogen and fat synthesis
59
What is the main goal of the postabsorptive state?
To maintain blood glucose levels within a homeostatic range, especially for the brain
60
What are the main sources of glucose during the postabsorptive state?
1. Liver glycogenolysis (first ~4 hours) 2. Muscle glycogen → lactate/pyruvate → liver (gluconeogenesis) 3. Lipolysis: fats → glycerol → glucose 4. Protein breakdown (prolonged fasting): amino acids → glucose
61
What is glucose sparing?
During fasting, glucose is reserved for the brain, while other tissues use: - Fatty acids - Glycerol - Ketone bodies
62
What is glucagon’s role in the postabsorptive state?
Glucagon (from alpha cells of pancreas): - Stimulates glycogenolysis - Stimulates gluconeogenesis from amino acids, lactate, and glycerol - Opposes the action of insulin