Week 6 Flashcards
(15 cards)
What were some of the more important symptoms that hinted @ Barbara’s condition?
Low Glucose Levels Anxiety Disorder Hormonal Issues High Thyroid Hormone Cardiac Problems increased metabolic rate weight loss feels warm hand tremor
Barbara has a Family Hx of hypothyroidism. Does this mean that she must have hypo too?
No, she could easily have hyper even with her family hx.
In a radioactive iodine uptake test…what would it mean if iodine wasn’t being taken up well but the t3 & T4 were high…
Thyroiditis (can’t uptake iodine b/c of acute injury to the thyroid gland)
In a radioactive iodine uptake test…what would it mean if iodine was being taken up well & the T3 & T4 were high…
Graves’ disease
What would it mean if there was just one spot or a couple of spots of high iodine uptake on the radioactive iodine uptake test?
a hot nodule, or several hot nodules…
What would an ultrasound of the thyroid consistent w/ Graves’ look like?
a larger gland, with huge blood vessel activity
What is one of the main ways to treat Graves’ disease?
radioactive iodine
What is the mechanism for increased O2 consumption with an increase in thyroid hormone?
Genomic & non-genomic effects increase sodium potassium pump action…this increases O2 consumption & basal metabolic rate
How does T3 widen pulse pressure?
It decreases peripheral vascular resistance thru vasodilation…this decreases diastolic pressure
It also increases HR, CO & SV which increases systolic pressure.
This causes a wide pulse pressure.
What are some important tests to conduct to confirm a diagnosis of Graves’ disease?
TSH, T3, & T4 levels
CBC–rule out infection or anemia
ultrasound to visualize the thyroid gland
Look for antibodies stimulating the TSH receptor
What are some things that could quickly confirm a diagnosis of Graves’ disease & make an ultrasound of the thyroid unnecessary?
presence of thyroid stimulating immunoglobulin
exopthalmos
Where is TSH secreted from?
thyrotropes of the adenohypophysis
What is an example of when TSH could be low in hyperthyroidism & what is an example of when TSH could be low in hypothyroidism?
Hyperthyroidism: Grave’s disease–>TSIs against TSH receptors & high T3 & T4 w/ negative feedback to TSH
Hypothyroidism: secondary–>disorder of adenohypophysis or hypothalamus–>impaired TSH release
What is the fastest way to distinguish b/w primary hyperthyroidism & secondary hyperthyroidism?
TSH levels
Primary: Low TSH
Secondary: High TSH
Why is free T4 ordered instead of total T4?
b/c the free T4 is the stuff that will be affecting the tissues
if there is hyperthyroidism–>then the transport proteins will be saturated & there will be more free T4.
