Week 6.4 Flashcards

(69 cards)

1
Q

Where are implicit and explicit memories stored?

A
  • implicit: more diffusely (cerebellum and striatum)

- explicit: medial temporal lobe

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2
Q

Something will stay in your short-term memory for as long as you ___.

A

rehearse it

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3
Q

The process of transferring immediate to short-term memory is called what?

A

working memory

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4
Q

Where does the transfer of information from working memory to long-term memory occur?

A

in the limbic circuits

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5
Q

Working memory is mediated by what brain region?

A

the dorsolateral prefrontal cortex

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6
Q

Long-term memory can be relatively unaffected even if ___ of the cortex has been damaged.

A

25%, they are resistant because they are stored in a network

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7
Q

Which memory system depends on the intactness of the cortex?

A

working memory

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8
Q

Long term potentiation is mediated by what NT system?

A

NMDA receptors and glutamate

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9
Q

What is memory consolidation?

A

the process that strengthens a memory after it’s initial acquisition

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10
Q

The memory circuit is named what?

A

the Papez circuit

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11
Q

What brain region is involved in short-term memory?

A

the Papez circuit

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12
Q

What sort of damage is required to disrupt short-term memory?

A

bilateral damage to the Papez circuits

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13
Q

How can we test working memory?

A
  • digit span
  • 5-7 unrelated word or numbers
  • repeat a brief story
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14
Q

Orientation to time and place is a test of what kind of memory?

A

short-term

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15
Q

How can we test short-term memory?

A
  • orientation to time and place

- remember a word list for three minutes

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16
Q

What are some etiologies for isolated amnestic syndromes?

A
  • large frontal lesion
  • midline thalamic lesion
  • basilar occlusion
  • thiamine deficiency
  • anoxia
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17
Q

What is “hollywood” amnesia?

A

a psychogenic memory loss in which short-term memory is preserved but long-term memory is severely compromised

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18
Q

What kind of memory problems are common with normal aging?

A
  • forget specific dates and names
  • remember what they forgot
  • can accurately track ongoing events
  • memory deficit is inconsistent
  • remote memories are forgotten more than recent
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19
Q

What sorts of memory are affected in the early and late stages of Alzheimer’s disease?

A
  • early: short-term memory

- late: working and long-term memory

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20
Q

Trauma will most often affect what kind of memory?

A

short-term memory

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21
Q

What is anterograde amnesia?

A

the inability to form new memories

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22
Q

What is retrograde amnesia?

A

the inability to retrieve formerly learned information

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23
Q

Wernicke’s encephalopathy is due to what?

A

thiamine deficiency

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24
Q

Which brain regions are selectively vulnerable to thiamine deficiency?

A
  • dorsal medial thalamic nuclei

- maxillary bodies

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25
What are the features of Korsakoff's psychosis?
- anterograde and retrograde amnesia | - confabulation
26
What is the most common cause of confabulation amongst alcoholics?
Korsakoff's psychosis
27
What cell types comprise the taste bud?
- taste receptor cells - supporting cells - basal cells
28
Which categories of taste are mediated by direct ionic channels?
- salty | - sour
29
Which categories of taste are mediated by second messenger systems?
- sweet - bitter - umami
30
Which cranial nerves supply gustatory afferents?
CN VII, IX, X
31
Which brainstem nuclei mediates taste?
the solitary nucleus
32
Describe the pathway of taste afferents into the CNS.
- CN VII, IX, X - rostral half of solitary nucleus - thalamus - inferior lateral somatosensory cortex
33
What kind of receptors bind olfactants and mediate smell?
g-protein coupled receptors
34
Olfactory receptor cells project where?
to glomeruli in the olfactory bulb where they synapse onto mitral cells
35
What is special about olfactory cells?
they are neurons, thus demonstrating one case of adult neurogenesis
36
The olfactory tract is formed by axons from what cell population?
mitral cells
37
Describe the direct pathway for olfactory receptor information into the cortex.
- olfactory receptor cell - mitral cell in the olfactory bulb - piriform cortex - orbitofrontal cortex
38
Name the four major functions of the limbic system.
- Homeostasis - Olfaction - Memory - Emotions and Drives
39
What brain structure projects to and passes memories into the cortex?
the hippocampus
40
Olfactory information enters the hippocampus via what route?
directly through the entorhinal cortex rather than passing through the thalamus
41
Describe the three layers of the dentate gyrus.
- innermost polymorphic - granule cell layer - outermost molecular
42
What is the perforant pathway?
projections from the entorhinal cortex to granule cells in the dentate gyrus
43
What are mossy fibers?
projections from dentate granule cells to hippocampal pyramidal cells
44
What are the three layers of the hippocampus?
- polymorphic - pyramidal - molecular
45
Pyramidal cells in the hippocampus receive input from what two sources?
- mossy fibers | - perforant path fibers
46
Where do hippocampal pyramidal cells project?
out of the hippocampus via the fornix
47
The amygdala has what three major regions?
- central - corticomedian - basolateral
48
What is the role of the central amygdala?
- autonomic control
49
The central amygdala receives input form the ___ and projects to the ___.
- viscerosensory relay nuclei | - hypothalamus and brainstem ANS nuclei
50
What is the role of the corticomedian amygdala?
feeding and sexual activity
51
The corticomedian amygdala receives input form the ___ and projects to the ___.
- olfactory bulb and piriform cortex | - septum and hypothalamus
52
What is the role of the basolateral amygdala?
interpret the emotional importance of events
53
The basolateral amygdala receives input from the ___ and projects to the ___.
- neocortical sensory association cortex | - hypothalamus, nucleus accumbens, orbitofronal cortex
54
The hypothalamus has descending input onto what two other systems?
- the pituitary | - sympathetic preganglionic neurons
55
What are the four functions of the hypothalamus?
- homeostasis - endocrine - autonomic - limbic
56
What are the two systems through which the hypothalamus controls the pituitary?
- neurohypophyseal | - tuberoinfundibular
57
Describe the neurohypophyseal system.
neurons form the supraoptic and paraventricular nuclei project to the posterior pituitary and release oxytocin and vasopressin
58
Describe the tuberoinfundibular system.
neurons from the arcuate and periventricular nuclei project to the anterior pituitary and release releasing factors
59
Name four homeostatic functions of the hypothalamus.
- feeding/eating - temperature regulation - circadian rhythm - thirst/body fluid
60
What part of the hypothalamus is activated by heat and which is activated by cold?
- anterior nucleus by heat | - posterior nucleus by cold
61
What hypothalamic nuclei is responsible for the body's temperature set point?
the pre-optic nucleus
62
Which hypothalamic nuclei sense satiety and hunger?
- ventromedial: satiety | - lateral: hunger
63
A lesion of the ventromedial hypothalamic nuclei will result in what?
an overabundance of feeding activity
64
What are leptins?
hormones released by adipose tissue to reduce appetite
65
What is ghrelin?
a hormone produced in the gastric mucosa to stimulate apetite
66
What hypothalamic nucleus controls circadian rhythm?
the suprachiasmatic nucleus
67
Which hypothalamic nucleus releases vasopressin?
the supraoptic nucleus
68
Which hypothalamic nucleus regulates the autonomic nervous system?
paraventricular neurons
69
Name four places the hypothalamus receives input from?
- retina - fornix - amygdala - medial forebrain bundle