week two review

Question 1

a patient has the following thyroid profile, name the disorder:
decreased total T4
decreased FT4
positive TPO ab
increased TSH

Answer 1

Hashimoto’s thyroiditis
- autoimmune (TPOab) hypothyroidism

Question 2

the primary serum test to screen for thyroid disease is

Answer 2

TSH

Question 3

what is the major carrier protein of the thyroid hormones in the blood

Answer 3

thyroxine binding globulin (TBG)

Question 4

a pregnant pt presents to OBGYN in 1st trimester of pregnancy w/ abnormal ultrasound readings, normal hCH, and AFP values of 8 MoM (normal <2). what is most likely manifesting in the fetus

Answer 4

neural tube defects
- seen w/ increased MoM but normal hCG

Question 5

which of the following is not quantified in the triple test for down syndrome
- alpha -1 fetoprotein
- unconjugated estriol
- hCG
- progesterone

Answer 5

progesterone

Question 6

A laboratory measures maternal serum AFP (MS-AFP) at 16-18 weeks gestation as a screen for fetal disorders. The 16 week MS-AFP median is 32 mg/L and a 37 year old woman has a MS-AFP level of 34 mg/L. This result is consistent with:

Answer 6

normal AFP for 16 week gestation
- normal: 0.5-2.0 MoM
- serum AFP/median AFP