White Blood Cell

Question 1

Leukemia’s are _____ and ____

Answer 1

Acute and chronic

Question 2

Leukemia ____ and _____ cells; Malignant cells of the ______ that spill into peripheral blood

Answer 2

Myeloid
Lymphoid

Bone marrow

Question 3

Leukemia’s may spread to involve solid tissues typically

Answer 3

Liver and spleen

Question 4

Hodgkin lymphoma is a lymphoma of a distinctive cell type

Answer 4

Reed Sternberg Cell

Question 5

Hodgkin lymphoma arises in

Answer 5

A single lymph node eventually spreading to involve contiguous nodes

Question 6

Which is the good lymphoma

Answer 6

Hodgkin lymphoma

Question 7

How many types of Hodgkin lymphoma are there

Answer 7

5

Question 8

Reed Sternberg cell

Answer 8

Large cell
Mirror nuclei
Germinal center B lymphocyte origin

Question 9

__________ is often present in Reed Sternberg cell

Answer 9

Epstein Barr virus

Question 10

Spreading of Hodgkin lymphoma is predicable

Answer 10

Lymph nodes
Spleen
Liver
Bone marrow

Question 11

Low Stage Hodgkin lymphoma

Answer 11

Localized involvement

Question 12

High stage Hodgkin lymphoma

Answer 12

Wide srepad disease with distant or bone marrow involvement

Question 13

Stage I Hodgkin lymphoma

Answer 13

Tumor in one anatomic region

OR

2 contiguous anatomical regions on the same side of the diaphragm

Question 14

Stage II Hodgkin lymphoma

Answer 14

Tumor in more than 2 anatomic regions

OR

2 non-contiguous regions on the same side of the diaphragm

Question 15

Stage III Hodgkin lymphoma

Answer 15

Tumor on both sides of the diaphragm not extending beyond lymph nodes or spleen

Question 16

Stage IV Hodgkin lymphoma

Answer 16

Tumor in bone marrow lung any organ outside of the lymph nodes

Question 17

Hodgkin lymphoma “B” signs

Answer 17

Fever night sweats and significant unexplained weight loss

Question 18

Non-Hodgkin Lymphoma _____ lymphocytes originating __________

Answer 18

Neoplasticism

Lymph nodes

Extranodal lymphoid tissue

Question 19

Most Non-Hodgkin lymphoma cells are of ______ origin

Answer 19

B cell

The remained are T cell

Question 20

Non-Hodgkin lymphoma Growth pattern

Answer 20

Nodular or diffuse

Question 21

Non-Hodgkin lymphoma: _______ better than ______

Answer 21

Nodular disease

Diffuse

Small cells better than large

Question 22

Non-Hodgkin lymphoma prognosis often based more on

Answer 22

Sub type of lymphoma than stage

Question 23

Acute Leukemia

Answer 23

Rapid onset weight blasts in the blood

Myeloid and lymphoid cells affected

Question 24

Chronic Leukemais

Answer 24

Indolent onset and tends to involve more mature cells

Myeloid and lymphoid cells affected

Question 25

Acute Lymphoblastic Leukemia clonal gorowth

Answer 25

Of primitive lymphoid cell Both B and T cell types exist

Question 26

Acute Lymphoblastic Leukemia most common in

Answer 26

Children under 15

Question 27

Acute Lymphoblastic Leukemia increased ____ count

Answer 27

White blood cell count often accompanied with thrombocytopenia

Question 28

Acute Lymphoblastic Leukemia children prognosis

Answer 28

Good Adults: bad

Question 29

Acute Myelogenous Leukemia clonal proliferation

Answer 29

Of primitive myeloid cell More common in adults

Question 30

Acute Myelogenous Leukemia increased

Answer 30

WBC often with anemia and thrombocytopenia

Question 31

Acute Myelogenous Leukemia ______ is present in the cytoplasm

Answer 31

Myeloperoxidase

Question 32

Chronic Lymphocytic Leukemia clonal proliferation

Answer 32

Of MATURE B lymphocytes, identical to small lymphocytic lymphoma

Question 33

Chronic Lymphocytic Leukemia usually express surface

Answer 33

IgM with kappa light chain restriction

Question 34

Chronic Lymphocytic Leukemia high expression of

Answer 34

BCL2

Question 35

Most common adult leukemia

Answer 35

Chronic Lymphocytic Leukemia

Question 36

Chronic Lymphocytic Leukemia suppress normal B cells leading to

Answer 36

Hypogammaglobulinemia

Question 37

Chronic Myelogneous Leukemia Clonal Prolifeation of

Answer 37

IMMATURE granulocytes | -a stem cell disorder

Question 38

Cytogenetic abnormality -Philadelphia chromosome

Answer 38

Chronic Myelogenous Leukemia

Question 39

Chronic Myelogenous Leukemia molecular fusion of

Answer 39

bcr and abl genes This is what chemotherpay targets

Question 40

Plasma Cell Proliferation

Answer 40

My little Myeloma

Question 41

Multiplied Myeloma monoclonal ________production

Answer 41

Heavy and or light chain | -IgG most common

Question 42

Multiple Myeloma will have

Answer 42

Multiple lyric bone lesion hypercalcemia

Question 43

Multiple Myeloma RBC show

Answer 43

Rouleaux formation | -stacking

Question 44

Circulating plasma cells in blood

Answer 44

Normally uncommon

Question 45

Multiple myeloma prognosis

Answer 45

Variable poor