XIX - Female Genital System and the Breast Flashcards Preview

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Flashcards in XIX - Female Genital System and the Breast Deck (151)
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61

A rare, solid, unilateral ovarian tumor consisting of an abundant stroma containing nests of transitional-like epithelium resembling that of the urinary tract.

Brenner Tumor (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

62

Unilateral ovarian tumor composed of sheets or cords of large cleared cells separated by scant fibrous strands. Stroma may contain lymphocytes and occasional granuloma. Usually occur on the 2nd-3rd decade of life.

Dysgerminoma(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

63

Unilateral ovarian tumor which occur during the 1st 3 decades of life. Characterized by small, hemorrhagic focus with syncitiothrophoblast and cytotrophoblast. Metastasize early.

Choriocarcinoma(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

64

Sex cord tumor seen most commonly in postmenopausal women. Lesions may be tiny or large, gray to yellow (with cystic spaces). Produce large amounts of estrogen. (+) Call-Exner bodies

Granulosa-thecal cell tumor(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

65

Sex cord tumor characterized by solid gray fibrous cells to yellow (lipid-laden) plump thecal cells. Most hormonally inactive.

Thecoma-fibroma tumor(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

66

Sex cord tumor seen as small, gray to yellow-brown, and solid lesions. May resemble development of testis with tubules, or cords and plump pink Sertoli cells. May be masculinizing or defeminizing.

Sertoli-Leydig cell tumor(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

67

On transection, filled with sebaceous secretion and matted hair, bonw and cartilage, nests of bronchial or gastrointestinal epithelium, and other recognizable lines of development are also present.

Benign (Mature) Cystic Teratomas / Dermoid Cyst(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 733

68

Microscopically, the distinguishing feature is a variety of immature or barely recognizable areas of differentiation toward cartilage, bone, muscle, nerve, and other structures. Found early in life.

Immature Malignant Teratomas (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 733

69

Tumor of the ovary composed entirely of mature thyroid tissue. May hyperfunction and produce hyperthyroidism. Appear as small, solid, unilateral brown ovarian masses

Struma ovarii (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 733

70

A voluminous mass of swollen, sometimes cystically dilated, chorionic villi, appearing grossly as grapelike structures.

Hydatidiform Mole (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 735

71

This type of H. mole shows hydropic swelling of chorionic villi and virtual absence of vascularization of villi. No fetal parts seen.

Complete mole (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 736

72

This type of H. mole shows villous edema that involves only some of the villi and the trophoblastic proliferation is focal and slight, with characteristic irregular scalloped margin. Fetal parts/embryo may be seen.

Partial mole(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 736

73

These are complete moles that are more invasive locally but do not metastasize. Microscopically, the epithelium of the villi is marked by hyperplastic and atypical changes, with proliferation of both cuboidal and syncytial components.

Invasive Mole (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 736

74

Appear as very hemorrhagic, necrotic masses within the uterus. The tumor is purely epithelial, composed of anaplastic cuboidal cytotrophoblast and syncytiotrophoblast, chorionic villi are not formed. High propensity for metastasis.

Choriocarcinoma (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 737

75

A cystic dilation of an obstructed duct that arises during lactation.

Galactocele (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 739

76

Multifocal, bilateral blue-brown cysts ("blue dome cysts") of the breast, measuring 1-5 cm diameter, filled with serous turbid fluid. Occurs normally in the menstrual cycle.

Simple fibrocystic change of the breast(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 739

77

Term used to describe hyperplasia that cytologically resemble lobular carcinoma in situ, but the cells do not fill or distend more than 50% of the acini within a lobule.

Atypical lobular hyperplasia (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 739

78

The lumen of the ducts, ductules, or lobules of the breast is filled with a heterogeneous population of cells of different morphologies. Irregular slit-like fenestrations are prominent at the periphery.

Epithelial Hyperplasia (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 739

79

These lesions are characterized by proliferation of lining epithelial cells and myoepithelial cells in small ducts and ductules, yielding masses of small gland patterns within a fibrous stroma. The acini are arranged in a swirling pattern, and the outer border is usually well circumscribed.

Sclerosing Adenosis (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 741

80

A nonbacterial chronic inflammation of the breast associated with inspissation of breast secretions in the main excretory ducts.

Mammary duct ectasia (periductal or plasma cell mastitis) (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 742

81

The lesion is small, often tender, rarely more than 2 cm in diameter, and sharply localized, with a central focus of necrotic fat cells surrounded by neutrophils and lipid-filled macrophages. Caused by some antecedent trauma to the breast.

Traumatic fat necrosis (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 742

82

The most common benign neoplasm of the female breast.

Fibroadenoma(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 742

83

A discrete, usually solitary, freely movable nodule, 1 to 10 cm in diameter, easily "shelled out" lesion of the breast. Histologically there is a loose fibroblastic stroma containing ductlike, spaces lined by a layer of epithelium that are regular and have a well-defined, intact basement membrane.

Fibroadenoma (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 742

84

Small lobulated and cystic lesion of the breast that may grow rapidly. Exhibit "leaflike" clefts and slits on gross section.

Phyllodes Tumor (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 743

85

A neoplastic papillary growth within a duct, usually solitary and less than 1 cm in diameter, consisting of delicate, branching growths within a dilated duct or cyst.

Intraductal Papilloma (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 743

86

A type of noninvasive carcinoma of the breast that tends to fill, distort, and unfold involved lobules and thus appears to involve ductlike spaces.

Ductal Carcinoma in Situ(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 745

87

A type of noninvasive carcinoma of the breast expands but does not alter the underlying lobular architecture. cells are monomorphic with bland, round nuclei and occur in loosely cohesive clusters in ducts and lobules. Tend to be bilateral, and increases risk for development of breast CA.

Lobar Carcinoma in Situ(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 746

88

Caused by the extension of DCIS up to the lactiferous ducts and into the contiguous skin of the nipple.

Paget disease of the nipple (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 746

89

This type of cancer produces a desmoplastic response, replacing normal breast fat and forms a hard, palpable mass. Advanced cancers may cause dimpling of the skin, retraction of the nipple, or fixation to the chest wall.

Invasive ductal carcinoma (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 747

90

Breast cancer defined by the clinical presentation of an enlarged, swollen, erythematous breast, usually without a palpable mass. The blockage of numerous dermal lymphatic spaces by carcinoma results in the clinical appearance (e.g peau d' orange)

Inflammatory carcinoma (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 747