Flashcards in XIX - Female Genital System and the Breast Deck (151)
Breast cancer which consists of cells morphologically identical to the cells of LCIS. Occasionally they surround cancerous or normal-appearing acini or ducts, creating a so-called "bull's-eye pattern."
Invasive lobular carcinoma (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 747
A rare subtype of carcinoma consisting of sheets of large anaplastic cells with pushing, well-circumscribed borders, with a pronounced lymphoplasmacytic infiltrate.
Medullary carcinoma (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 747
A rare subtype of carcinoma which appear grossly as a soft and gelatinous mass which abundant quantities of extracellular mucin that dissects into the surrounding stroma.
Colloid (mucinous) carcinoma (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 747
Usually present as irregular mammographic densities. Microscopically, the carcinomas consist of well-formed tubules with low-grade nuclei. Lymph node metastases are rare, and prognosis is excellent.
Tubular carcinomas (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 747
Grossly, appears as a button-like, subareolar swelling. in bilateral breasts of males.
Gynecomastia (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 750
Morphology: large macrophages with granular PAS positive cytoplasm and several dense, round Michaelis Gutmann bodies.
In gonococcal infection of the female reproductive system, inflammatory changes will appear about how many days after the inoculation of the organism?
2-7 days (TOPNOTCH)
These cells are distinguised by a clear separation "halo" from the surrounding epithelial cells and a finely granular cytoplasm containing mucopolysaccharide that stains with PAS, Alcian Blue, and Mucicarmine
Paget cells (TOPNOTCH)
What is the probable precursor of vaginal adenocarcinoma?
Vaginal adenosis (TOPNOTCH)
What do you call the glandlike structures filled with an acidophilic material similar to immature follicles that are seen in Granulosa Theca Cell tumors?
Call Exner bodies (TOPNOTCH)
Presence of these structures characterize serous tumors of the ovaries
Psammoma bodies (TOPNOTCH)
These tumors are distinguished from serous and mucinous tumors of the ovaries by the presence of tubular glands that resemble the endometrium
Endometriod tumor (TOPNOTCH)
Morphology: whorled pattern of smooth muscle bundles and well differentiated spindle shaped smooth muscle cells
A key factor in the development of endometrial hyperplasia and related cancers is the inactivation of what tumor suppressor gene?
What is the most common location of vaginal adenocarcinoma?
Anterior wall of the upper third of Vagina (TOPNOTCH)
This is a condition in which glandular columnar epithelium of mullerian type either appears beneath the squamous epithelium or replaces it
Vaginal Adenosis (TOPNOTCH)
What are the 4 cardinal histologic features of Lichen Sclerosus of the Vulva or Chronic atrophic vulvitis?
Atrophy of the epidermis with disappearance, of the rete pegs, hydrophic degeneration of the basal cells, replacement of the underlying dermis by dense collagenous fibrous tissue, and monoclonal band like lymphocytic infiltrate (TOPNOTCH)
Morphology: acanthosis of the vulvar squamous epithelium frequently with hyperkeratosis
Lichen SImplex Chronicles (TOPNOTCH)
Morphology: presence of large tumor cells lying singly or in small lusters within the epidermis and its appendages
Extra mammary Paget Disease (TOPNOTCH)
Morphology: tumor cells resemble tennis racket with small protrusions of cytoplasms from one end
Embryonal Rhabdomyosarcoma (TOPNOTCH)
Clustering of tumor cells in a so called "Cambium Layer" is seen in what type of rhabdomyosarcoma?
Embryonal Rhabdomyosarcoma (TOPNOTCH)
On histological examination of the cervix, epithelial spongiosis is associated with what type of infection?
T. vaginal infection (TOPNOTCH)
On histological examination of the cervix, epithelial ulcers with intranuclear inclusions within the epithelial cells and lymphocytic infiltration is associated with what type of infection?
Morphology: these are composed of dense fibrous stroma covered with endocervical columnar epithelium
Endocervical polyp (TOPNOTCH)
What is considered the most important agent in cervical oncogenesis?
Koilocytic atypia is considered what type of CIN lesion?
CIN I (TOPNOTCH)
What is the most common pattern seen in invasive cervical carcinoma?
On histological examination of the endometrium, what is the earliest morphological evidence of ovulation?
Basal vacuolation (TOPNOTCH)
Morphology: ectopic endometrial glands and stroma with numerous macrophages containing hemosiderin