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Grace Kraatz
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Decks in this class (35)
Blood Brain Barrier
When was the bbb discovered and b...,
How did they discovered the bbb 2,
The brain receives __ of cardiac ...
90
cards
BBB Drug Delivery
__ of small molecules and ___ of ...,
2 key props of drugs that pass th...,
P gp role in drug permeability 3
56
cards
Stroke I & II
Stroke definition 1,
Stroke vs ischemia 2,
Ischemia 3
128
cards
Epilepsy I & II
Hippocrates view of epilepsy 1,
What hippocrates got right 2,
Hippocrates on epilepsy onset 3
144
cards
PAIN I
Nociception 1,
What is meant when we say that no...,
Pain 3
79
cards
PAIN II
Pathway to brain 1,
Terminations of pain pathways and...,
Spinoreticular tract projects to 3
82
cards
PAIN III: Neuropathic
First pain is carried by 1,
Second pain is carried by 2,
Neuropathic pain involves 3
49
cards
Animal models of pain
2 types of chronic pain 1,
Chronic pain arises due to 2,
Chronic pain is often ___ and res...
65
cards
Placebo
Placebo definition 1,
Placebo examples 2,
Placebo effect definition 3
51
cards
Odorants
How is the olfactory system a pri...,
Dual requirement of the olfactory...,
Olfactory sensory neurons are fou...
28
cards
Mood Disorders I
Physiological correlates of fear ...,
Feelings are 2,
Feelings allows 3
90
cards
Mood Disorders II
Ssri goal 1,
How ssris work 2,
5ht precursor is 3
87
cards
SCZ
Scz and psychotic disorders exist...,
Positive symptoms meaning 2,
Positive symptoms examples 3
66
cards
Dementia I
2 major categories of memory 1,
Declarative memory is 2,
Non declarative memory is 3
70
cards
Dementia II
Ad definition 1,
Ad afflicts about in population o...,
Etiologically only __ ad are due ...
73
cards
MS I
Global distribution of ms risk an...,
Areas most affected by ms 2,
Ms prevalence in canada 3
79
cards
MS II
2 treatment options 1,
Disease modifying treatments 2,
Symptom treatments 3
69
cards
PD I
Voluntary movement originates in ...,
The 2 tracts of the pyramidal sys...,
Structures of the extrapyramidal ...
65
cards
PD II
Why use l dopa over da 1,
L dopa converted to da by 2,
L dopa admin efficacy 3
79
cards
PD III
Why do we care about lewy bodies 1,
What are lewy bodies 2,
Lewy body makeup 3
66
cards
HD I
Hd is a genetic neurodegenerative...,
Prevalence of ______ in caucasian...,
2 types based on age of onset 3
67
cards
HD II
The goal of hd treatment 1,
Pharmacological approaches to tre...,
Gold standard treatment of motor ...
55
cards
ALS
Als stands for 1,
Als aka 2,
Als definition 3
72
cards
Dystonia and Tourette Syndrome
Dystonia 1,
Dystonia disorders 2,
Classifications of dystonia 3
37
cards
Caspases
The most consistent risk factor f...,
Aging begins when 2,
Damage from aging 3
81
cards
Mitochondria
Mitochondrial dysfunction in neur...,
Role of mit 2,
Positive roles of mit 3
50
cards
Excitotoxicity I
How excitotoxicity influences neu...,
Excess calcium effects in excitot...,
Old view of excitotoxicity 3
22
cards
Excitotoxicity II
Competitive antagonists of the nm...,
Side effects of antagonizing the ...,
T f antagonizing the nmdar is a g...
44
cards
Heat Shock Proteins
Brain amyloidoses 1,
Amyloid structure toxicity 2,
Structure of amyloid aggregates o...
51
cards
Intro into Cellular Degradation
Proteostasis 1,
Why is proteostasis important 2,
How is proteostasis achieved 3
67
cards
Lysosomal Degradation: Autophagy
Cellular and foreign cargo 1,
Subtypes of autophagy 2,
______ are the major degradative 3
48
cards
The UPS in NDDs
Maintaining proteostasis in neuro...,
The ups is critical for functioni...,
Dysfunction of the ups in ndds ca...
31
cards
Autophagy in NDDs
Autophagy protects against neurod...,
Why are dmaaged mitochondria bad ...,
Why are protein aggregates bad an...
30
cards
Targeting the UPS to Treat NDDs
Areas to target the ups for treat...,
Protacs 2,
Structure of protacs 3
29
cards
Targeting Autophagy to Treat Neurodegenerative Diseases
Targeting autophagy in ndds 1,
Limitations in targeting autophag...,
Enhancing protein clearance by ac...
44
cards
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PMCOL 412
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