Flashcards in 03 Hormone diseases Deck (14):
How do you treat excess hormone production?
selective ablation with drugs (adrenal)
selective ablation with radionuclides (thyroid)
drugs that block hormone production (ex thyroid)
drugs that block hormone action (anti-estrogens, anti-androgens)
What are the mechanisms of endocrine disease
hormone resistance (problems with receptors)
What is the most common endocrine problem
What is a major example of hormone deficiency
Autoimmune attack, Type 1 Diabetes
body targets and attacks cells that make insulin
What are the 3 questions for a veterinarian regarding hormones and disease?
What can go wrong?
Can you fix it?
Can you treat it?
What are the causes of hormone deficiency?
can be due to a destructive process in the gland in which an insufficient amount of hormone is produced
physical compression / destruction by tumor growth
autoimmune attack (Type I diabetes)
genetic defects in production
inactivating mutations of receptors
alterations in receptor number and function
What is an example of hormone deficiency caused by genetic defects in hormone production?
congenital GH deficiency
common in german shepherds
how do you treat hormone deficiency?
What are the common diseases you will treat as a vet using hormone replacement?
diabetes mellitus (insufficiency of adrenal steroids)
major aspect of veterinary practice especially small animal
What is an example of hormone deficiency caused by inactivating mutations of receptors?
Testicular Feminization Syndrome
Thyroid Hormone Resistance
What are causes of hormone excess?
hormone may be overproduced by gland that normally secretes it, or by a tissue that is not an endocrine organ
malignant transformation of non-endocrine tissue causes dedifferentiation and ectopic production of hormonally active factors (anal sac tumors)
What hormone can be deficient without resulting in disease?
What are examples of endocrine gland tumors that produce hormone in an unregulated manner?
anal sac tumors in dogs produce parathyroid hormone-related protein