031315 antimanic drugs Flashcards
1
Q
lithium
A
no behavioral effects in the normal population
treats mania and prevents recurrence of bipolar disease
inhibits phosphtase that converts IP2 to IP1
2
Q
pharmacokinetics of lithium
A
narrow therapeutic window
Na levels affect Li levels (increased Na excretion causes clinically significant increases in Li levels)
3
Q
alternatives to lithium for tx of bipolar disorder
A
carbamazepine
valproic acid and divalproex sodium
lamotrigene, topiramate
for intial control of manic symptoms: haloperidol or clonazepam
symbyax (combo of olanzapine and fluoxetine)
