032515 drugs of abuse

Question 1

general substance use disorder criteria

Answer 1

problematic use within 12 month period w 2 or more symptoms that cause impairment in functioning

psychological and/or physiological dependence aren’t necessary for diagnosis

Question 2

cannabidiol

Answer 2

component in marijuana that has medicinal properties (not the same properties as delta9THC)

Question 3

MOA of THC

Answer 3

binds to CB1 receptor, which is highly expressed in cerebellum, hippocampus, and basal ganglia. binds to CB2 receptor which is in peripheral tissue

negatively coupled to andnylyl cyclase via Gi. inhibits transmitter release.

there are endogenous ligands (endocannbinoids) for the CB1 receptor

Question 4

marijuana effects

Answer 4

• euphoria
• memory impairment
• perceptual-motor alterations (driving-impaired)
• cardiovascular (dose related tachycardia and orthostatic hypotension, exacerbates angina)
• pulmonary (bronchodilation, lung irritant-may bronchoconstrict, decrease alveolar macrophage activity, decrease ciliary fxn)
• reproductive (lowers testosterone, etc)
• psychopathological effects (anxiety, paranoia)

Question 5

therapeutic uses of marijuana

Answer 5

control of nausea, AIDs wasting syndrome

in Cananda-for MS pain and cancer pain

Question 6

ketamine and PCP (phencyclidine) effects

Answer 6

autonomic and cardio system-sympathomimetic:

• tachycardia
• HTN
• potentiation of catecholamines

CNS:

• small doses-“drunken” state with numbness
• moderate doses-analgesia and anesthesia
• cataleptoid motor phenomenon
• psychic state
• large doses-may hv convulsions

Question 7

ketamine and phencyclidine MOA

Answer 7

non-competitive NMDA antagonist (block ion channel)

also block NE and dopamine reuptake

Question 8

overdose of phencyclidine

Answer 8

CNS: anxiety, aggression, halluciations, dysphoria, convulsions, delirium

sympathomimetic: tachycardia, HTN crisis

Question 9

indoleamines

Answer 9

includes LSD, psilocin (from mushrooms). structures are similar to 5HT

Question 10

phenethylamines

Answer 10

includes MDMA, mescaline. structures are similar to dopamine, amphetamine, methamphetamine.

more sympathomimetic than the indoleamines

Question 11

LSD effects

Answer 11

EXTREMELY potent
sympathomimetic-tachycardia, increased BP, psychomotor stimulation

sensory and subjective effects: altered VISUAL perception, mood labile, impaired judgment

Question 12

MDMA effects

Answer 12

known as ecstasy

feelings of “well being and connection”, altered time perception

psychomotor stimulation, restlessness, bruxism, anorexia, sweating, tremor