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Renal > 05.06 - RBF, GFR (Rao) - PP, Lecture Guide, No reading, Not watched > Flashcards

05.06 - RBF, GFR (Rao) - PP, Lecture Guide, No reading, Not watched Flashcards

(43 cards)

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1
Q

What effect on net filtration pressure does lower urinary tract obstruction have?

A

Increase Pbs –> Decrease GFR

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1
Q

How does sympathetic activation affect Resistance, RPF, GFR

A

Constriction of Aff and Eff -> Dec RPF and Pg -> Dec GFR

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1
Q

How does Ang 2 affect renal arteriolar resistance and GFR

A

Induces renal arteriolar constriction and reduces GFR, paradoxically opposing auto regulation

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2
Q

How does Sympathetic affect Kf

A

Decrease Kf by stimulating mesangial cells -> Dec GFR

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3
Q

How does DM affect GFR

A

Decreases Kf, so decreases GFR

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3
Q

Higher NaCl at MD =

A

Inc Afferent Arteriolar R -> Dec GFR

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3
Q

Proteinuria can either be from barrier failure or ___

A

Abnormal Circulating Protein (breakdown of tissue, production of abnormal proteins)

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4
Q

How does dec Cl in DT affect Renin

A

Inc Renin -> Inc Ang II, etc

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5
Q

Net Filtration Pressure =

A

(Pg + Pibs) - (Pig + Pbs)

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7
Q

How does Uretral Obstruction affect GFR, FF?

A

Reduce GFR and thus FF

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7
Q

Kf =

A

Filtration Coefficient = Hydraulic Conductivity x SA of Glomerular Capillaries

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7
Q

Mechanism of GFR Autoreg: Dec GFR ->

A

Dec Cl in distal tubule -> MD -> Dec Arteriolar Resistance -> Inc GFR

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7
Q

When is Autoregulation more important vs Sympathetics

A

Autoregulation dominates under normal conditions; Sympathetics only under severe ECFV loss

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8
Q

How does Endothelin affect GFR

A

Constrict Arterioles (aff and eff) -> Dec GFR

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9
Q

How do sympathetics control renin

A

B1 receptors stimulate renin in JG cells

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11
Q

2 locations where hydrostatic pressure drops

A

Afferent Arteriole; Efferent Arteriole/Peritubular Capillary

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14
Q

Size of Albumin

A

6nm or 60 angstroms

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14
Q

How does Low Capillary Flow affect FF, Pig, Net filtration pressure, GFR

Study These Flashcards
A

Inc FF -> Inc Pig -> Dec Net Filtration Press -> Dec GFR

14
Q

T/F: Autoregulation in kidney depends on sympathetic input?

Study These Flashcards
A

False, isolated in kidney

16
Q

GFR =

Study These Flashcards
A

Kf x Net filtration pressure

17
Q

Lower NaCl at MD =

Study These Flashcards
A

Dec Afferent Arteriolar R -> Inc GFR

18
Q

Two Theories of Autoregulation

Study These Flashcards
A

Myogenic, Tubuloglomerular Feedback

19
Q

Adrenaline vs Endothelin 1 on resistance

Study These Flashcards
A

Adrenaline is perferentially for Afferent, Endothelin does both

20
Q

How does decreased efferent resistance affect GFR, RPF

Study These Flashcards
A

Decreased GFR, Increased RPF

21
How does Adrenaline affect GFR
Constrict Arterioles (preferentially afferent) -\> Dec GFR
23
Normal GFR is __ mL/min, ___ L/day
130 mL/min; 180 L/day
24
Size of glomerular pores
8nm or 80 angstroms
24
How does increased efferent resistance affect GFR, RPF?
Increase GFR, Decrease RPF
25
Hydraulic Conductivity x SA of Glomerular Capillaries
Kf (Filtration Coefficienty)
26
How does Renal Artery Stenosis affect RPF, FF?
Reduces RPF, thus increases FF
27
Anions and Cations in Glomerulus vs Ultrafiltrate
4-5% more anions in ultrafiltrate and 4-5% less cations - Gibbs Donnan effect
28
What is the filtration fraction?
GFR / RPF
30
How does decreased Afferent resistance affect GFR, RPF
Increase GFR, RPF
32
How does increase Afferent resistance affect GFR, RPF?
Decrease GFR, RPF
33
When does sympathetic response act on nephron?
Overrides autoregulation in severe ECFV loss
35
What does the Tubuloglomerular feedback mechanism sense
NaCl at Macula Densa
36
Alternate route that Inc GFR -\> Inc Arterolar R
Inc GFR -\> Inc Cl in DT -\> Na-K-Cl in MD cells -\> Release ATP or AA metabs -\> SM contraction -\> Inc Art R
37
How does NO affect GFR?
Decreased Vascular R -\> Inc GFR
38
How does pressure affect renin release
Increased pressure in afferent arteriole inhibits renin release from JG cells; Vice versa
40
How do PG's affect GFR?
Decreased Vascular R -\> Inc GFR
41
The kidneys receive what percent of cardiac output?
20%
42
Source of Endothelin that affects GFR?
Damaged endothelial cells
43
Mechanism of GFR Autoreg: Inc GFR -\>
Inc Cl in distal tubule -\> MD -\> Inc Arteriolar Resistance -\> Dec GFR

Renal (31 decks)

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