05.22 - Renal Neoplasia (Handorf) - PP + Handout Flashcards Preview

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Flashcards in 05.22 - Renal Neoplasia (Handorf) - PP + Handout Deck (49):
1

WAGR and Denys-Drash are both associated with abnormalities of

Wilms Tumor 1 gene

2

Malignant neoplasm composed of cells with clear or eosinophilic cytoplasm w/in delicated vascular network

Clear Cell RC

2

2 different appearances of Papillary Carcinoma depending on angle of section

Nipples vs Papillae

3

Small renal cortical papillary neoplasms

Very common, look just like renal papillary carcinomas under microscope

3

Does RCC spread better hematogenously or by lymph

About equal

4

Most common type of renal cell carcinoma

Clear cell

5

Which subtype is more prone to bilateral or multifocal tumors

Papillary

6

Beckwith-Wiedemann Syndrome is associated with

loss of genetic imprinting that normally silences allele controlling ILGF2

6

loss of genetic imprinting that normally silences allele controlling ILGF2

Beckwith-Wiedemann Syndrome is associated with

7

What is helpful to radiologists in dx oncocytoma

Central Stellate Scar

7

Risk factors and average age for renal cell carcinoma

Smoking, HTN, Obesity - 64 years

7

3 congenital malformations associated with Wilms Tumor

WAGR Syndrome, Denys-Drash, Beckwith-Wiedemann

8

Large pale cells with prominent cell membranes

Chromophobe Carcinoma

10

Origin of Renal Cell Carcinoma

Renal Tubular Epithelium

11

Papillary Renal Cell Carcinoma

Short nipple-like or long finger-like projections of tumor cells in fibrovascular stalk

11

Behavior of Oncocytoma

Benign

12

Chromophobe Renal Cell Carcinomas

Large pale cells with prominent membranes

13

Chromophobe RCC is positive for

Hale's colloidal iron stain

14

Genetic signature of Oncocytoma

None

15

Abundant cytoplasmic little red bacteria-size dots

Mitochondria in Oncocytoma

16

What is predictably common in renal cell carcinomas

Hemorrhage - tumoral blood vessels are abnormal and prone to rupture

16

Genetics of Papillary RCC

MET mutation

18

Where do Renal Cell Carcinomas spread

Perinephric Fat, Lungs, Bone, Lymph Nodes

19

Uncommon benign epithelial neoplasms arising from intercalated cells of CD

Oncocytoma

20

Why do CCC's appear cystic

Liquefactive necrosis

21

MET mutation

Genetics of Papillary RCC

22

Oncocytoma

Uncommon benign epithelial neoplasms arising from intercalated cells of CD

24

Mahogony Brown kidney mass

Oncocytoma

25

Wilm's tumor is composed, microscopically, of

a mixture of cellular elements: blastemal, stromal, epithelial

26

Very common, look just like renal papillary carcinomas under microscope

Small renal cortical papillary neoplasms

27

What causes "empty" appearance of CCC on US

Liquefaction

29

vHL mutations

Clear Cell Renal Carcinoma

30

Small round blue cells, abortive tubules or glomeruli, fibroblastic stromal cells, and anaplastic cells

Wilms Tumor is composed of

31

Which subtype of Renal Cell Carcinoma has best prognosis

Chromophobe (aneuploidy)

33

Most common presentation of Wilms tumor

Abdominal mass

34

Clear Cell Carcinoma cells may form

Abortive Tubules

36

Grossly mahagony brown w/ central stellate scar

Oncocytoma

37

Wilms Tumor is composed of

Small round blue cells, abortive tubules or glomeruli, fibroblastic stromal cells, and anaplastic cells

38

Activating mutations in MET --> TKR for HGF

Papillary Renal Cell Carcinoma is associated with what mutations

39

Mutations in Clear Cell Carcinoma and consequence

vHL -> excess HIFs lead to excess VEGF

40

Clear Cell Carcinoma is composed of cells with ____ corrleated with ___ apparent grossly

Vacuolated (lipid-laden) cytoplasm, correlated with yellow color grossly

41

Short nipple-like or long finger-like projections of tumor cells in fibrovascular stalk

Papillary Renal Cell Carcinoma

42

Why does CCC have delicate vascular network

VEGF/vHL

43

Second and Third Most common types of Renal Cell Carcinoma

Papillary and then Chromophobe

45

Central Stellate Scar

Oncocytoma

46

Papillary Renal Cell Carcinoma is associated with what mutations

Activating mutations in MET --> TKR for HGF

47

Acquired dialysis related renal cystic disease

60% clear/ 40% papillary

48

Positive for Hale's colloidal iron stain

Chromophobe Carcinoma

49

First and Second most frequent presenting symptom of RCC

Hematuria, Dull Flank Pain