05.22 - Renal Neoplasia (Handorf) - PP + Handout

Question 1

WAGR and Denys-Drash are both associated with abnormalities of

Answer 1

Wilms Tumor 1 gene

Question 2

Malignant neoplasm composed of cells with clear or eosinophilic cytoplasm w/in delicated vascular network

Answer 2

Clear Cell RC

Question 2

2 different appearances of Papillary Carcinoma depending on angle of section

Answer 2

Nipples vs Papillae

Question 3

Small renal cortical papillary neoplasms

Answer 3

Very common, look just like renal papillary carcinomas under microscope

Question 3

Does RCC spread better hematogenously or by lymph

Answer 3

About equal

Question 4

Most common type of renal cell carcinoma

Answer 4

Clear cell

Question 5

Which subtype is more prone to bilateral or multifocal tumors

Answer 5

Papillary

Question 6

Beckwith-Wiedemann Syndrome is associated with

Answer 6

loss of genetic imprinting that normally silences allele controlling ILGF2

Question 6

loss of genetic imprinting that normally silences allele controlling ILGF2

Answer 6

Beckwith-Wiedemann Syndrome is associated with

Question 7

What is helpful to radiologists in dx oncocytoma

Answer 7

Central Stellate Scar

Question 7

Risk factors and average age for renal cell carcinoma

Answer 7

Smoking, HTN, Obesity - 64 years

Question 7

3 congenital malformations associated with Wilms Tumor

Answer 7

WAGR Syndrome, Denys-Drash, Beckwith-Wiedemann

Question 8

Large pale cells with prominent cell membranes

Answer 8

Chromophobe Carcinoma

Question 10

Origin of Renal Cell Carcinoma

Answer 10

Renal Tubular Epithelium

Question 11

Papillary Renal Cell Carcinoma

Answer 11

Short nipple-like or long finger-like projections of tumor cells in fibrovascular stalk

Question 11

Behavior of Oncocytoma

Answer 11

Benign

Question 12

Chromophobe Renal Cell Carcinomas

Answer 12

Large pale cells with prominent membranes

Question 13

Chromophobe RCC is positive for

Answer 13

Hale’s colloidal iron stain

Question 14

Genetic signature of Oncocytoma

Answer 14

None

Question 15

Abundant cytoplasmic little red bacteria-size dots

Answer 15

Mitochondria in Oncocytoma

Question 16

What is predictably common in renal cell carcinomas

Answer 16

Hemorrhage - tumoral blood vessels are abnormal and prone to rupture

Question 16

Genetics of Papillary RCC

Answer 16

MET mutation

Question 18

Where do Renal Cell Carcinomas spread

Answer 18

Perinephric Fat, Lungs, Bone, Lymph Nodes

Question 19

Uncommon benign epithelial neoplasms arising from intercalated cells of CD

Answer 19

Oncocytoma

Question 20

Why do CCC's appear cystic

Answer 20

Liquefactive necrosis

Question 21

MET mutation

Answer 21

Genetics of Papillary RCC

Question 22

Oncocytoma

Answer 22

Uncommon benign epithelial neoplasms arising from intercalated cells of CD

Question 24

Mahogony Brown kidney mass

Answer 24

Oncocytoma

Question 25

Wilm's tumor is composed, microscopically, of

Answer 25

a mixture of cellular elements: blastemal, stromal, epithelial

Question 26

Very common, look just like renal papillary carcinomas under microscope

Answer 26

Small renal cortical papillary neoplasms

Question 27

What causes "empty" appearance of CCC on US

Answer 27

Liquefaction

Question 29

vHL mutations

Answer 29

Clear Cell Renal Carcinoma

Question 30

Small round blue cells, abortive tubules or glomeruli, fibroblastic stromal cells, and anaplastic cells

Answer 30

Wilms Tumor is composed of

Question 31

Which subtype of Renal Cell Carcinoma has best prognosis

Answer 31

Chromophobe (aneuploidy)

Question 33

Most common presentation of Wilms tumor

Answer 33

Abdominal mass

Question 34

Clear Cell Carcinoma cells may form

Answer 34

Abortive Tubules

Question 36

Grossly mahagony brown w/ central stellate scar

Answer 36

Oncocytoma

Question 37

Wilms Tumor is composed of

Answer 37

Small round blue cells, abortive tubules or glomeruli, fibroblastic stromal cells, and anaplastic cells

Question 38

Activating mutations in MET --\> TKR for HGF

Answer 38

Papillary Renal Cell Carcinoma is associated with what mutations

Question 39

Mutations in Clear Cell Carcinoma and consequence

Answer 39

vHL -\> excess HIFs lead to excess VEGF

Question 40

Clear Cell Carcinoma is composed of cells with ____ corrleated with ___ apparent grossly

Answer 40

Vacuolated (lipid-laden) cytoplasm, correlated with yellow color grossly

Question 41

Short nipple-like or long finger-like projections of tumor cells in fibrovascular stalk

Answer 41

Papillary Renal Cell Carcinoma

Question 42

Why does CCC have delicate vascular network

Answer 42

VEGF/vHL

Question 43

Second and Third Most common types of Renal Cell Carcinoma

Answer 43

Papillary and then Chromophobe

Question 45

Central Stellate Scar

Answer 45

Oncocytoma

Question 46

Papillary Renal Cell Carcinoma is associated with what mutations

Answer 46

Activating mutations in MET --\> TKR for HGF

Question 47

Acquired dialysis related renal cystic disease

Answer 47

60% clear/ 40% papillary

Question 48

Positive for Hale's colloidal iron stain

Answer 48

Chromophobe Carcinoma

Question 49

First and Second most frequent presenting symptom of RCC

Answer 49

Hematuria, Dull Flank Pain