05.05 - Homeostasis (Rao) - Lecture, no reading Flashcards Preview

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Flashcards in 05.05 - Homeostasis (Rao) - Lecture, no reading Deck (34):
1

Formula for Plasma Osmolarity

(2 x Na mM) + (Glucose mOsm) + (Urea mOsm)

2

Major cation in ICF

K+

3

What happens to normal RBC when placed in solution of Low Pna and High Glycerol

Initially shrinks, then swells

4

Probes for Total Body Water

2H2O, 3H2O, Antipyrene

5

Major extracellular anion

Cl-

5

Is Cl- greater in plasma or interstitial fluid

Greater in interstitial fluid (Gibbs Donnan Effect)

5

Formula for BV

BV= PV/(1-Hct)

6

Probe for measuring ECFV

Inulin, Thiosulfate, Na+

8

Major cation in ECF

Na+

9

Is HCO3- greater in ICV or ECV

ECV

9

Is PO4+ greater in ICV or ECV

ICV

10

How does Infusion of Isotonic Salt Solution change ECF and ICF

Increase ECF, no change in ICF

11

Formula for ICF

ICF = TBW - ECF

12

Is SO4+ greater in ICV or ECV

ICV

12

Permeability of Na, Urea, Water, Glycerol across PM

Im, Per, Per, Slowly permeable

14

What causes Gibbs Donnan Effect?

Proteins impermeable to PM - Anionic so bind Na in plasma and repel Cl- into interstitial fluid

16

Is Cl greater in ICV or ECV

ECV

16

How do you correct for filtration/excretion in calculating ECF

Subtract excreted value from numerator

17

Ca2+ in ICF vs ECF

None in ICF

18

Is Na greater in plasma or interstitial fluid

Plasma (Gibbs Donnan Effect)

19

Formula for ISF (interstitial)

ISF = ECF - PV

21

What percent of Blood is plasma vs rbc

60% plasma, 40% rbc

21

If probe is metabolized, will it over or underestimate the volume

Overestimate

23

What to look for when elevated Osmolarity Gap

Missing Osmotic particle

24

2 Major anions in ECF

Cl-, HCO3

25

3 Major anions in ICF

Protein, Bicarb, Phosphate

27

If probe is synthesized, will it overestimate or underestimate volume?

Underestimate

28

What Osmolarity gap is abnormal

>10

29

What percent of water intake is from food + drink

88%

30

Is Mg greater in ICV or ECV

ICV

31

What percent of TBW is BV

8%

32

Formula for PV with probe

PV = Q / Conc.

33

Why is Inulin good probe for ECFV

Smaller than Albumin, can diffuse across capilary wall but not PM

34

Probe for measuring PV

131 I-Albumin, Evans blue dye