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Renal > 05.21 - Drug Tx of Renal Cancer (Sweatman) > Flashcards

05.21 - Drug Tx of Renal Cancer (Sweatman) Flashcards

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1
Q

Admin of IFN-alpha 2b

A

SC 3 x weekly

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1
Q

Coca Cola urine =

A

Rhabdomyolysis

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2
Q

Toxicity of Cyclophosphamide

A

Meylo; Hemorrhagic Cystitis (mesna)

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3
Q

Maculopapular rash, mucositis, anemia, fatigue

A

Rapamycins

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4
Q

IFN-alpha 2b is used off label to treat

A

Clear Cell RCC

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5
Q

Adminstration of high dose IL-2 is akin to

A

Induction of controlled state of septic shock

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5
Q

Pharmacologic support for patients taking Aldesleukin

A

Abx, Dopamine for GFR, Phenylephrine for BP support, Fever and Chills, PPI for hyperacidity

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6
Q

Destructive metastic RCC sites

A

Lung Liver Bone

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7
Q

Axitinib

A

Only approved as follow tx after failur of initial drugs

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7
Q

Black box warnings for Bevacizumab

A

Hemm, GI perforations, Wound healing complications

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8
Q

Patients with Bilateral RAS are dependent on ___ to maintain renal perfusion

A

RAAS

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8
Q

Action of Insulin on K levels

A

Na/H exchanger –> Drives K from blood into cells –> Serum K drops

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9
Q

Drug that causes Hypotension

A

Bevacizumab

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9
Q

Patients taking Aldesleukin have high potential for

A

Sepsis

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10
Q

Spironolactone causes what in men

A

Gynecomastia (similar structure to steroids)

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11
Q

Dactinomycin Toxicity

A

Myelo; Hepatic Dysfuncion, Infection

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12
Q

Toxicity of Carboplatin

A

Myelo; Infection

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13
Q

mTOR blockers

A

Everolimus, Temsirolimus

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13
Q

Cockroft-Gault Formula

A

accounts for age and sex

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15
Q

Standard chemo agents for Wilm’s post nephrectomy

A

Vincristine, Dactinomycin, Doxorubicin (Cyclo, Etoposide)

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15
Q

Mesna

A

Antidote to Cyclophosphamide and Ifosfamide

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16
Q

Black box warnings for IFN-alpha 2b

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A

Neuropsych, AI, Ischemic and Infectious disorders

17
Q

3 causes of Hyperkalemia mention by sweatman

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A

Lysis, Statins, Crush injury

18
Q

Most common adverse effects of IFN-alpha 2b

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A

Fatigue, fever, flu-like symptoms; Leukopenia, Neutropenia

20
Etoposide Toxicity
Hematologic Toxicity; BP instability
21
Sign of Rhabdomyolysis
Coca Cola urine
22
Effect of Insulin on heart
Cardiotonic, independent of Beta1
23
\_\_ are contraindicated in Bilateral RAS
ACEi's and ARB's
24
Tx of BB or CCB overdose
Insulin + Glucose
26
Bilateral sensory "stocking-glove"
Vincristine
27
In fit patients with mets at dx and minimal symptoms, what provides the best survival strategy
Nephrectomy followed by IFN-alpha
29
Only approved as follow up therapy after failure of initial drug
Axitinib
29
How does HypoMg cause HypoK
Doesn't allow K to exit ROMK channel, just enter
31
Most common metastatic site for RCC
Lymph Nodes
32
Route of Temsirolimus vs Everolimus
Weekly IV vs Daily Oral
33
Ifosfamide Toxicity
Hemorrhagic Cystitis (mesna)
34
At physiological Mg concentrations,
Mg occludes ROMK channel, preventing K from exiting cell
35
2 CYP substrates
TKIs, Rapamycins
36
Patients taking this drug have high potential for sepsis
Aldesleukin
37
Renal fxn in men vs women
Higher in men
38
Most drugs for adult RCC target
VEGF due to etiology from vHL mutations
40
Cytotoxic chemo in Adult vs Pediatric RCC
Ineffective in adults
41
Chronic NSAID tx is not good for
elderly patients, especially if taking anti-HTN
43
Results of clinical trials with low dose intermittent pulse IL-2
Disappointing
44
Hepatic Dysfunction Tox
Dactinomycin
45
Admin of Aldesleukin
IV to hospitalized patients
46
Endogenous IFN activation results in transcriptional upregulation of
Genes responsible for Anti-viral, Anti-proliferative, and Anti-tumor activities
48
Low dose infusion of IL-2 leads to selective expansion of
A subset of NK cells that overexpress high affinity IL-2 receptor
49
Patients with recurrent Clear Cell Sarcoma involving brain respond to
ICE: Ifosfamide, Carboplatin, Etoposide
50
Resistance to the Rapamycins (-limus)
Second mTOR complex
51
Sorafenib blocks
VEGFR, PDGFR, KIT, RAF
52
Pulmonary Infiltrates
Temsirolimus and Everolimus
53
Fatigue, Fever, Flu-Like symptoms
IFN-alpha 2b
54
Aldesleukin (IL-2) and IFN-alpha are used in treatment of
Clear Cell RCC

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