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Flashcards in 1,2,3 Deck (83)
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1

Recognized as foreign by the immune system and provoke an immune response when introduced into the tissues of an immunocompetent individual

Antigen

2

Normal protein or complex of proteins. Should not normally be the target of the immune system, due to mainly genetic and environmental factors an immune response to these antigens has developed

Autoantigen

3

Have a homogeneous, restricted nature. They recognize only the corresponding antigen that caused its production

Monoclonal Antibody

4

Major histocompatibility complex antigens that are found on virtually every living cell

MHC Class I

5

Cell surface protein antigens found on nucleated cells and tissue that readily provoke an intense immune response. Originally Human Leukocyte Antigens. Second only to ABO antigens in importance.

Histocompatibility Antigens

6

Capacity to react with antibodies induced in an immune response. Influenced by molecular size , electrical charge, solubility, shape of molecule and chemical composition

Antigenicity

7

Result of different Bcell lines(memory cells) producing different Ab again same pathogen.

Polyclonal Antibodies

8

Major histocompatibility complex antigens that are restricted to B-lymphs, activated T-lymphs, monocytes, macrophages, and endothelium cells

MHC Class II

9

Study of Ag/Ab reactions as they relate to blood disorders and the use of blood products

Immunohematology

10

Ab that is produced by one individual and reacts with Ag found in other members of the same species

Alloantibodies

11

Large Y shaped protein. Neutralizes anything identified as nonself such as bacteria, viruses and potentially transfused donor cells

Antibodies

12

Glycoproteins and glycolipids bound to cell membranes are primarily responsible for the molecular structures

Antigenic Determinants/ Epitope

13

Major histocompatibility complex antigens that activate complement and cytokines

MHC Class III

14

What chain and region of an antibody determines what class the antibody is?

Heavy chain; constant region

15

What part of the antibody is specific for one particular epitope on an antigen?

Paratope

16

Allergic and Parasitic Infections

IgE

17

can be found in body secretions, such as saliva, tears and areas containing mucus

IgA

18

Produced FIRST in an immune response. Cold Temps. Low Titers. 900,000 Daltons

IgM

19

Antigen receptor on B-lymphs. Increased levels associated with autoimmune disorders

IgD

20

Smallest class of immunoglobulins, reacts best at body temp. Most abundant. Only class that can cross placenta. There are 4 subclasses

IgG

21

What IgG subclass(es) bind with high affinity to phagocytic cells?

IgG1 & IgG3

22

What IgG subclass(es) can NOT cross the placenta?

IgG2

23

What IgG subclass(es) are most effective complement activator?

IgG3

24

What are the two only immunoglobulins capable of complement activation?

IgG & IgM

25

What ions must be present for complement activation?

Calcium and Magnesium

26

What complement pathway is activated by a single IgM antibody or two or more IgG antibodies in close proximity?

Classical

27

Give complements for each stage
CLASSICAL
Recognition-
Activation-
Membrane Attack-

- C1
- C4, C2, C3(C3 convertase)
- C5 through C9(C5 convertase)

28

Give complements for each stage
ALTERNATE
Recognition-
Activation-
Membrane Attack-

- C1
- C2, C3, C4 , C3b
- C5b, C6, C7, C8, C9

29

What complement pathway is activated by bacterial cell walls, bacterial lipopolysaccharide, fungal cell walls, virus infected cells?

Alternate Pathway

30

A position on a chromosome

Locus