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[1] Lecture 11 Flashcards

(10 cards)

1
Q

most numerous cells in CT

A

Fibroblasts and fibrocytes

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2
Q

Fibroblast and fibrocytes functions:

A

Secretion and maintenance of CT matrix.

Secretion and precursor fibrous molecules

Secretion a don amorphous components of the matrix, including the glycosaminoglycans

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3
Q

Resident cells in CT:

A

Macrophages
Mast cells
Plasma cells

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4
Q

Macrophage characteristics :

A
  • 10-30 micrometers.
  • Oval shaped, indented heterochromatic nucleus.
  • capable of ameboid movement
  • part of mononulclear phagocytic system [ras]
  • extensive golgi, rER, ER, mitochondria secretory vesicles to activate immune response by presenting the antigen to T cells
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5
Q

How are macrophages named?

A

Based on location in the body:

Liver sinusoids=kupffer cells.
CNS=microglia
Bone reabsorption= osteoclasts

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6
Q

Mast cells characters:

A
  • irregularly oval in outline
  • small spherical/ovoid nuclei masked by membrane-bound granules.
  • stain w/ toludine blue
  • large metachromatic granules w/ histamine, ECF, SRS, and heparin.
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7
Q

MAst cells functions/location

A
  • Involved in hypersensitive response to allergens: edema, shock, pain, hypercoagulation, fever
  • Membranes release leukotrienes
  • found near small blood vessels
  • absent from spleen.
  • Found in mucosal surfaces and in CT
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8
Q

Plasma cell characters:

A
  • activated B lymphocytes
  • resemble lymphocytes but are larger.
  • large pale nuclei w/ “clock-face’ distribution of heterochromatin.
  • prominent golgi and extensive RER
  • rare in CT.
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9
Q

Where do plasma cells frequently occur?

A

Serous membranes

Lymphoid tissue

Lamina propria of gut tract

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10
Q

Main function of plasma cell=

A

Activated B cell; thus, it secretes immunoglobulins to bind to antigen in ECF to neutralize

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