[1] Lecture 11

Question 1

most numerous cells in CT

Answer 1

Fibroblasts and fibrocytes

Question 2

Fibroblast and fibrocytes functions:

Answer 2

Secretion and maintenance of CT matrix.

Secretion and precursor fibrous molecules

Secretion a don amorphous components of the matrix, including the glycosaminoglycans

Question 3

Resident cells in CT:

Answer 3

Macrophages
Mast cells
Plasma cells

Question 4

Macrophage characteristics :

Answer 4

• 10-30 micrometers.
• Oval shaped, indented heterochromatic nucleus.
• capable of ameboid movement
• part of mononulclear phagocytic system [ras]
• extensive golgi, rER, ER, mitochondria secretory vesicles to activate immune response by presenting the antigen to T cells

Question 5

How are macrophages named?

Answer 5

Based on location in the body:

Liver sinusoids=kupffer cells.
CNS=microglia
Bone reabsorption= osteoclasts

Question 6

Mast cells characters:

Answer 6

• irregularly oval in outline
• small spherical/ovoid nuclei masked by membrane-bound granules.
• stain w/ toludine blue
• large metachromatic granules w/ histamine, ECF, SRS, and heparin.

Question 7

MAst cells functions/location

Answer 7

• Involved in hypersensitive response to allergens: edema, shock, pain, hypercoagulation, fever
• Membranes release leukotrienes
• found near small blood vessels
• absent from spleen.
• Found in mucosal surfaces and in CT

Question 8

Plasma cell characters:

Answer 8

• activated B lymphocytes
• resemble lymphocytes but are larger.
• large pale nuclei w/ “clock-face’ distribution of heterochromatin.
• prominent golgi and extensive RER
• rare in CT.

Question 9

Where do plasma cells frequently occur?

Answer 9

Serous membranes

Lymphoid tissue

Lamina propria of gut tract

Question 10

Main function of plasma cell=

Answer 10

Activated B cell; thus, it secretes immunoglobulins to bind to antigen in ECF to neutralize