[1] Lecture 11 Flashcards
(10 cards)
most numerous cells in CT
Fibroblasts and fibrocytes
Fibroblast and fibrocytes functions:
Secretion and maintenance of CT matrix.
Secretion and precursor fibrous molecules
Secretion a don amorphous components of the matrix, including the glycosaminoglycans
Resident cells in CT:
Macrophages
Mast cells
Plasma cells
Macrophage characteristics :
- 10-30 micrometers.
- Oval shaped, indented heterochromatic nucleus.
- capable of ameboid movement
- part of mononulclear phagocytic system [ras]
- extensive golgi, rER, ER, mitochondria secretory vesicles to activate immune response by presenting the antigen to T cells
How are macrophages named?
Based on location in the body:
Liver sinusoids=kupffer cells.
CNS=microglia
Bone reabsorption= osteoclasts
Mast cells characters:
- irregularly oval in outline
- small spherical/ovoid nuclei masked by membrane-bound granules.
- stain w/ toludine blue
- large metachromatic granules w/ histamine, ECF, SRS, and heparin.
MAst cells functions/location
- Involved in hypersensitive response to allergens: edema, shock, pain, hypercoagulation, fever
- Membranes release leukotrienes
- found near small blood vessels
- absent from spleen.
- Found in mucosal surfaces and in CT
Plasma cell characters:
- activated B lymphocytes
- resemble lymphocytes but are larger.
- large pale nuclei w/ “clock-face’ distribution of heterochromatin.
- prominent golgi and extensive RER
- rare in CT.
Where do plasma cells frequently occur?
Serous membranes
Lymphoid tissue
Lamina propria of gut tract
Main function of plasma cell=
Activated B cell; thus, it secretes immunoglobulins to bind to antigen in ECF to neutralize