Flashcards in 1: Medical Math: Routes of Administration of Drugs (3) Deck (14):
What factors affect the selection of the route of administration of drugs?
1) Therapeutic factors
2) Drug factors
How do therapeutic factors affect the administration of drugs?
1) Onset and duration of action
2) Site of action
3) Adverse reactions
How do Drug factors affect the administration of drugs?
What are the two routes of administration for drugs?
What are the local routes of administration of drugs?
4) Urethral and bladder
9) GI tract
13) Intrasynovial (intra-articular)
14) Intramedullary (into bone marrow)
What are the systemic routes of administration of drugs?
1) Oral (per os, enteral)
2) Parental or by injection (Intravenous IV, subcutaneous SQ, Intramuscular IM)
3) Inhalation (gases, vapors, aerosol)
What are the advantages of Oral administration?
2) Convenient in some animals
4) No problem of infection
What are the disadvantages of Oral administration?
1) Inactivation of some drugs by gastric acidity, digestive enzymes or rumen microflora.
2) The presence of food may affect absorption
3) The presence of drugs may affect absorption
4) Activity of the GI tract affects absorption
5) Irritant drugs may cause vomiting and diarrhea
6) Onset of action is slow
7) Unpalatability of some drugs
What are the advantages of Intravenous injections?
2) Fast onset of action
3) Irritating, hypertonic, acidic, or basic drugs can be given
4) Large volume can be given
What are the disadvantages of Intravenous injections?
What are the advantages of Intramuscular injections?
1) Rapid absorption
2) Duration of action is longer than intravenous
3) Suspensions can be injected
What are the disadvantages of Intramuscular injections?
1) Irritant, hypertonic, acidic, or basic drugs may cause tissue damage
What are the advantages of Subcutaneous injections?
1) slow absorption but constant
2) Longer duration of action