PAH Flashcards
key drugs that can cause PAH
Cochise and meth, ssri during pregnancy, weight loss drugs
what is the cause of PAH
increase in vasodilator substances like TXA2 and decrease in vasodilating substances lkke prostacyclines
what is the most common cause of death in PAH?
heart failure
what are symptoms of PAH
fatigue, dyspnea
initial tx in a responder
CCB - not verapamil (diltiazem ok)
initial tx in a non responder
prostacycline analogs (iv epoprostenol), eras, pde5, sGC (all potient vasodilators)
flolan
epoprostenol
protect from light pneumonoc
protect - phytonadione- vit k
every - epoprostenol (flolan)
necessary- nitroprusside (nitropres)
med - micafungin (mycamine)
daylight- doxycycline
revatio
sildinefil
adcirca
tadalafil
what drugs can cause pulmonary fibrosis
amiodarone/dronedarone, bleomycin. busulfan, carmustine, lomustine
what is given to confirm the diagnosis of PAH?
right heart catheterization where short acting vaskdilators are administered
what is prostacyclin
potent vasodilators and inhibitors of platelet aggression
what is the problem with giving epoprosgenol IV?
increased risk of blood stream infection and infusion site pain
what is the likely side effect from a pogent vasidilator such as epoprostenol?
hypotension and flushing
