Gout Flashcards

1
Q

Which drugs increase uric acid

A

aspirin, calcinurin inhibitors (tacrolimus and cyclosporine), diuretics (loop and thiazides), niacin, pyrazinamide, some chemptherapy drugs with chemo lysis syndrome, pancreatic enzyme products

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2
Q

colcrys/colchisine dosing and when to start and resume prophylaxis dosing

A

two 0.6 tablets followed by 0.6 mg in 1 hour (1.8 mg in 1 hour max)

start within 36 hours of symptom onset and wait 12 hours after a treatment dose before resuming prophylaxis

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3
Q

colrys/colchisine contraindications

A

pgp or cyp inhibition

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4
Q

colcrys/colchisine side effects

A

gi symptoms, myopathy, myelosupression, neuropathy

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5
Q

Indocin

A

Indomethacin

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6
Q

Aleve

A

Naproxen

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7
Q

Celebrex

A

Celecoxib

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8
Q

Prednisilone

A

Prednisone

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9
Q

Medrol

A

Methylprednisone

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10
Q

side effects of steroids

A

increased blood glucose, blood pressure and appetite and insomnia

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11
Q

Methylprednisone gets delivered how

A

intramuscularly directly in joints

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12
Q

contraindications for nsaids

A

CVD and severe renal disease

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13
Q

What can be used for acute gout attack

A

NSAID, colchisne, steroids

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14
Q

UA goal for prophylaxis

A

<6mg/dL

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15
Q

gout prophylaxis treatment algorithm

A

Treat with an XOI and if UA still not below 6 then can add on probenecid or lesinurad or replace XOI with IV peglitocase (krystexxa)

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16
Q

When would febucostat be used

A

only when allopurinol is not tolerated (such as in hypersensitivity)

17
Q

Which foods to avoid in gout

A

organ meats, high fructose corn syrup, alchohol

18
Q

Zyloprim

A

Allopurinol

19
Q

Alloprim

A

Allopurinol

20
Q

Allopurinol warnings

A

hypersensitivity reactions including severe rash due to HLA-B 5801 testing prior to use (esp asians) and hepatotoxicity

21
Q

moa of uricosurics

A

Lesinurad and probenecid - inibit resorption of uric acid in the kidneys

22
Q

what is probenecid used for

A

to increase uric acid levels

23
Q

boxed warning for peglitocase

A

anaphylactic reactions - monitor and premedicate with antihistamines and steroids

24
Q

contraindications for pedlitocase

A

G6P6 deficiency

25
Q

xoi major DDI

A

mercatopurine, the active metabolite of azithioprine

26
Q

What is resburicase used for

A

the treatment of tumor lysis syndrome

27
Q

rasburicase contraindication

A

g6pd deficiency