11: Hypersensitivity Flashcards Preview

Dermatology Week 1 2017/18 > 11: Hypersensitivity > Flashcards

Flashcards in 11: Hypersensitivity Deck (27)
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1

What is hypersensitivity?

Immune response causing collateral damage

2

Allergic and autoimmune responses are example of what?

Hypersensitivity

3

What mediates Type I hypersensitivity reactions?

Antibodies (IgE)

4

type iv

5

time frames

6

Allergy involves reactions to ___ substances.

harmless

7

What name is given to harmless substances which cause allergic reactions?

Allergens

8

Type I reactions tend to occur ___.

immediately

9

Type I allergies tend to be (immediate / delayed) and (consistent / unpredictable).

immediate

consistent

10

Name an antigen-presenting cell which involved in Type I allergic responses.

Dendritic cells

Mast cells

11

Which cells produce the antibodies responsible for mediating Type I hypersensitivity reactions?

B cells

(also memory B cells)

12

What is urticaria?

Hives

i.e big red lumpy rashes

13

How long does urticaria typically last?

2-6 hours

14

angioedema

15

How can a Type I allergy be diagnosed?

Serum IgE test

Skin prick / patch testing

Challenge testing

16

serum tryptase

17

epipen doses

18

What is the jist of Type IV hypersensitivity reactions?

Delayed response

19

What mediates Type IV hypersensitivity reactions?

T cells

20

Name an example of Type IV hypersensitivity reactions.

Allergic contact dermatitis

21

How long after exposure to allergens do Type IV hypersensitivity reactions start?

24 - 48 hours

22

Give an example of a substance which causes a Type IV hypersensitivity reaction.

Nickel

Poison ivy

Thiuram (used in rubber gloves)

Colophany used in adhesives

Deodorant chemicals

garlic

stuff in tattoos

23

How can Type IV hypersensitivity be diagnosed?

Patch testing

24

Nappy rash and excessive handwashing are examples of which type of dermatitis?

Irritant contact dermatitis

25

Is irritant contact dermatitis an example of hypersensitivity?

No

not an immune response

26

atopic eczema

27

Dermatitis can be caused by allergens, irritants or ___.

infection e.g fungal