Where do melanocytes originate from?
Which organelle, found in melanocytes, is responsible for producing converting an amino acid to melanin?
What is this amino acid called?
Melanin absorbs ___ ___.
Melanocytes have long projections which allow them to transfer melanosomes between themselves - what are these projections called?
___ caps protect the nuclei of ___ layer cells.
Melanin , basal
Name an autoimmune disease which targets melanocytes.
Where are melanocytes found?
Basal layer AND above the basal layer
Where are Langerhans cells found?
Suprabasal (i.e in the prickle cell layer)
Where are Merkel cells found?
What is vitiligo?
Autoimmune disease causing destruction of melanocytes
Patient presents with loads of hypopigmented patches
What is albinism?
Complete / partial lack of pigment in skin, hair and eyes
Classic white appearance
What is Nelson's syndrome?
What causes it?
Excess melanin production leading to hyperpigmented skin
Overproduction of MSH by anterior pituitary
What is a tumour of melanocytes called?
Where do Langerhans cells originate from?
Bone marrow (immune function)
Langerhans cells pick up ___ and transfer them to lymph nodes via lymph vessels.
What are the tennis-racquet-shaped organelles found exclusively in Langerhans cells?
What is the function of Merkel cells?
Cancer of which epidermal cell is caused by viral infection and has a high mortality rate?
Merkel cell cancer
Which layer(s) of skin are hair follicles found in?
What substance is a hair follicle made of?
Which type of gland is found adjacent to hair follicles?
What is the deepest component of a hair follicle called?
Hair follicles are pigmented by melanocytes - where are these found?
Nail matrix (above the dermal papilla)
What is another name for a hair follicle?
What are the muscles responsible for moving hair follicles?
Arrector pili muscles
What are the three phases of hair growth?
What happens in the anagen phase of hair growth?
What happens in the catagen phase?
Involution - hair follicles get ready to shed
What happens in the telogen phase?
Name a hormone which influences hair growth.
Androgens - e.g testosterone