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Path Block 2 > 11- Restrictive Lung Disease > Flashcards

11- Restrictive Lung Disease Flashcards

(85 cards)

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0
Q

PFT test in RLD

A

Fev1/fec= same or increased

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1
Q

RLD has increased elasticity because of what ?

A

Fibrous tissue

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2
Q

What kind of cough in RLD

A

Dry cough

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3
Q

Type of fibrosis in restrict lung disease

A

Reticular
Modular
Retinulonodular

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4
Q

RLD of lung show what

A

Diffuse infiltrate -ground glass shadows

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5
Q

RLD what are the four pneumoconiosis

A

Asbestosis
Silicosis
Coal workers pneumoconiosis
Berylliosis

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6
Q

What are the three types of coal workers pneumoconicosis

A

Asymptomatic pulmonary anthracosis

Simple CWP

Complicated CWP

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7
Q

RLD from inorganic material leads to what disease

A

Pneumoconicosis

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8
Q

RLD that comes about from organic particles

A

Hypersensitivity pneumonitis

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9
Q

What lung Disease shows increase in diffuse linear markings in lung x ray

A

RLD

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10
Q

What is the mc pneumoconicosis and occupational lung disease in the world

A

Silicosis

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11
Q

What factors do macrophages release in RLD that lead to collagen deposition and fibrosis

A

Toxic factors
Pro inflammatory factors
Fibrogenic factors

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12
Q

Another name for coal dust

A

Anthracotic pigment

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13
Q

Microscopy of pulmonary Asymptomatic anthracosis has what?

A

Dust macrophage cells but no fibrosis

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14
Q

Simple CWP characteristics by what?

A

Nodular masses composed of collagen fibers and pigment

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15
Q

The other name for progressive massive fibrosis

A

Complicated CWP

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16
Q

Complicated CWP characterized by what ?

A

Fibrotic Opsacities >1cm on xray
Dense collagen
And Anthrocotic pigment

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17
Q

What is the complication of progressive massive fibrosis ?

A

Crippling lung disease , black lung disease

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18
Q

DD of black lung disease

A

Metastasis

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19
Q

What is coal workers lung

A

When Anthrocotic pigment turns fibrogenic

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20
Q

What and with what is caplan syndrome seen

A

Having one of the three disease plus RA nodules in arms and legs

Asbestos, silicosis , CWP

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21
Q

What is inhaled in silicosis

A

Crystalline silicone dioxide

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22
Q

Is anthracotic pigment fibrogenic

A

No

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23
Q

Is crystalline silicone dioxide fibrogenic

A

Yes

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24
Complication of RLD
Fibrosis -hypoxemia- PH-COR pulmonale- RHF
25
Two forms of silicosis
Amorphous | Crystalline
26
With silicosis you have increased risk of acquiring what infection
TB
27
Chronic nodular silicosis results in what in lung
Nodular opacities with concentric layers of collagen fibers **(purple )
28
Who acquires silicosis
Miners Sandblastee Mining
29
How are silicosis particles seen?
Birefringent polarized light
30
Where nj the lung does silicosis mostly occur
Apex
31
What differentiates asbestos from silicosis depending on nodules ?
Asbestos doesn't have large nodules
32
What fibers are carcogenic and what do they cause
Asbestos
33
Mc lesion associated with exposure to asbestos
Pleural plaques
34
Asbestos is a crystalline silicate with what subfamilies
Serpentine -chrysotile | Amphibole crocidolite
35
Mc form of cancer from asbestos
Broncogenic carcinoma
36
What are serpentine crystals where they go and what they cause -asbestos
Chrysotile asbestos crystals Curly and flexible Upper airway Interstitial fibrosis and Broncogenic carcinoma
37
What are amphibole crystals and where and what do they cause -asbestos
Crocidolite Straight -deep lung to pleura Lung cancer -Broncogenic carcinoma and mesothelioma
38
What are asbestos fibers phagocytosed by macrophages and coated by iron called ?
Ferruginous bodies -dumbbell
39
What stain to see ferruginous bodies
Prussian blue stain
40
Asbestos bodies are coated with what by macrophages
Iron and calcium, and proteinaceous materials
41
What are benign pleural plaques composed of in asbestos
Fibrosis and calcification
42
Where are benign pleural Plaques found
On pleura and domes of diaphragm
43
Age benign pleural plaques a precursor for mesothelioma
No
44
Asbestos can lead to what
Benign pleural plaques Diffuse interstitial fibrosis -bands if fibrosis Lung cancer
45
What does berylliosis result in
Diffuse interstitial fibrosis with noncaseating ganulomas
46
RLD that lead to noncaseating granulomas
Berylliosis Hypersensitivity pneumonitis Sarcoidosis
47
Hypersensitivity pneumonitis is due to what
Bacwrialmorndingal vegetable matter or moldy droppings repeated exposure
48
The other name for hypersensitivity pneumonitis
Allergic alveolitis
49
Is esonophIia present in hypersensitivity pneumonitis
No
50
What type of hypersensitivity is hypersensitivity pneumonitis
Type 3 and 4
51
Acute hypersensitivity pneumonItis is how long ? And HS?
4-6 hrs 3
52
Chronic hypersensitivity pneumonItis is what kind of HS
IV with fibrosis and interstitial non caseasting granulomas
53
Most common targets of sarcoidosis
Lung face Salivary gland Skin
54
What is the second most common RLD
Sarcoidosis
55
What is the mc noninfectious granulomatous disease of lung
Sarcoidosis
56
What is the antigen in sarcoidosis and what cell does it interact with to illicit what hypersensitivity reaction
Unknown antigen with cd4 helper cell- type IV reaction
57
Treatment for sarcoidosis
Steroids
58
X-ray sarcoidosis has what appearance ?
Reticulonodular potato pattern nodes -enlarged hilar lymph nodes
59
Diseases with granulomas?
``` Berylliosis Hypersensitivity pneumonitis-farmers lung Sarcoidosis TB Histoplasmosis ```
60
Why organ does sarcoidosis primarily target
Lungs
61
What does sarcoidosis granulomas contain ?
Multinucleated giant cells with Laminated calcium concentrates- schaumann bodies Stellate inclusions -asteroid bodies
62
Sarcoidosis is seen In what people ?
Seamstress
63
What does sarcoidosis cause I eyes
Uveitis blurry vision
64
What does sarcoidosis cause in skin ?
Painful Erythema nodosum- no Granuloma located in Ant.leg Nodular painless lesions - with granuloma
65
What does sarcoidosis do to the liver
Granulomatous hepatomegaly
66
What is the name of the syndrome I. Sarcoidosis that involves lacrimal gland and parotid enlargement ?
Mikulicz syndrome
67
Sarcoidosis patient presentation in lab? P.e.?
Hypercalcemia Increase ACE Deceased ADH Night sweats, cough -mc
68
Why does sarcoidosis have diabetes insidious
Hypothalamic and posterity pituitary disease so no ADH
69
What so the granulomas secret and what do they cause ?
Secrete 1alpha hydroxylase- Hypercalcemia (kidney,liver) ^ACE- hypertension
70
Sarcoidosis is a diagnosis of what?
Exclusion
71
Good pasture syndrome mostly occurs in what sex
Males
72
Good pasture characterized by
Glomerulinephritis Hemorrhagic interstitial pneumonitis Lung then kidney Hemoptysis then glomerulonephritis
73
What antibody is Involved in Good pasture against what?
IgG against alveolar and glomerular capillaries BM
74
Presentation if good pastures ?
Hematuria and proteinuria {ab)
75
What happens when goodpastures turns chronic?
Focal necrosis and hemorrhagic
76
What kind of HS is GP?
2
77
What disease has alveolar interstitial fibrosis of unknown ***origin and leads to dilation of airways with honeycomb appearance ?
Idiopathic pulmonary fibrosis Stretch alveoli no collapse No diaphragm depression
78
Honey come appearance is seen in what?
Eventually all restrictive lung disease
79
How are tlc and rv in restrictive ins disease ?
Both decreased
80
Pneumoconicosis inorganic material that are big get. Impacted where ?
Bifurcation of alveolar ducts
81
Which RLD has an increase risk to TB
Silicosis | Coal miners lung
82
What organisms are farmer lung exposed to?
Thermophilic actinimyces
83
RLD with nodules
Simple CWP Complex CWP Silicosis
84
RLD with reticulonodules
Sarcoidosis

Path Block 2 (19 decks)

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