20-neoplasm Thyroid

Question 0

In men and children nodules are most likely

Answer 0

Malignant

Question 1

In women majority of nodules are

Answer 1

Colloid filled cysts

Question 2

Cold nodules can be

Answer 2

Malignant or benign

Question 3

Hot nodules are always

Answer 3

Benign

Question 4

What is a follicular adenoma surrounded by

Answer 4

Capsule

Question 5

What is the name is a follicular adenoma is hot

Answer 5

Toxic adenoma with excess t3 and t4

Question 6

Mc carcinoma of thyroid

Answer 6

Papillary carcinoma

Question 7

2nd most common carcinoma of thyroid

Answer 7

Follicular carcinoma

Question 8

3rd most common carcinoma of thyroid

Answer 8

Medullary carcinoma

Para follicular cells

Question 9

4th mc carcinoma of thyroid

Answer 9

A aplastic carcinoma

Follicular cells

Question 10

What are the risk for thyroid cancer

Answer 10

Ionizing radiation to brain
Autoimmune thyroid diseases
Genetic factors
Iodine deficiencys

Question 11

What chromosome is the ret oncogene on ,involved in men-2

Answer 11

Chromosome 10

Question 12

Papillary carcinoma characteristics

Answer 12

Papillary pattern
Small psammoma bodies 
Clear chromatin-eye
Painless mass
Palpable lymph node-cervical spread

Question 13

What cancers have psammoma bodies

Answer 13

Mesothelioma
Meningioma
Papillary cystic cancer of ovary
Papillary carcinoma of thyroid

Question 14

Microscopic characteristic of follicular carcinoma

Answer 14

Numerous small follicles lined by malignant follicular cells

Question 15

Two things that distinguish follicular adenoma from carcinoma

Answer 15

Invasions of old vessels and invasion of capsule with follicular cells

Question 16

Where does follicular carcinoma like to metastasize to

Answer 16

Lungs and bones
-viscera
Hematogenous spread

Question 17

Is FNA enought to distinguish follicular adenoma from. Carcinoma

Answer 17

No

Question 18

What does medullary carcinoma secrete

Answer 18

Calcitonin increase

ACTH

Question 19

What does calcimine in medullary carcinoma lead to ?

Seen with what stain

Answer 19

Amyloid abnormal pattern seen with Congo red stain

Question 20

Gross appearance of medullary carcinoma

Answer 20

Soft consistency with necrosis in the center

Question 21

What autosomal familial syndromes is medullary carcinoma associated with

Answer 21

Men 1 and men2

Question 22

What do patients with men2a have

Answer 22

Medullary carcinoma of thyroid Hyperparathrodism

Phaeochromocytoma

Question 23

What do patients with MEN2b have

Answer 23

Medullary carcinoma of thyroid
Phaeochromocytoma
Mucosal neuromas of oral cavity and tongue

Marfan like

Question 24

Why are medullary carcinomas usually periphery

Answer 24

C cells migrate from neural crest to the lateral thyroid lobes so do not arise from thyroid isthmus or thyrogloss all duct remnants

Question 25

What goes the ret gene encode for

Answer 25

Tyrosine kinase receptor Affect cysteine rich extra cellular domains

Question 26

Where does medullary carcinoma like to metastasize to more than lymph nodes

Answer 26

Viscera and lymph nodes

Question 27

How is men2-b associated with ret gene

Answer 27

A single amino acid change affects a critical region of the tyrosine kinase catalytic core and is responsible for mucosal neuromas

Question 28

How does medullary carcinoma spread

Answer 28

Blood and lymph | Hematogenous and lymphatic

Question 29

What syndrome can medullary cArcinoma cause

Answer 29

Cushings Increased ACTH

Question 30

What is The tumor market for medullary carcinoma

Answer 30

Calcitonin

Question 31

Who does an aplastic thyroid carcinoma mostly occur in

Answer 31

Elderly woman

Question 32

Histology of anaplastic carcinoma

Answer 32

Undifferentiated anaplastic pleomorphic small or spindle shaped cells