11. Sjögren Syndrom Flashcards by Ian Paglione

Q

(SS)

Pathophysiologie

A

chronisch-entzündliche Autoimmunerkrankung

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Q

(SS)

Epidemiologie

A

einer der häufigsten Kollagenosen

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Q

(SS)

Ätiologien (2)

A

sPP
sSS

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Q

(SS)

pSS

A

primäres Sjögren-Syndrom

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Q

(SS)

sSS

A

sekundäres Sjögren-Syndrom

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Q

(SS)

pSS: Ursache

A

idiopatisch

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Q

(SS)

sSS: häufigste Ursachen (3)

A

RA
SLE
SSc

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Q

(SS)

Symptome (2)

A

lokale-
systemische-

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Q

(SS)

lokale Symptome (3)

A

Sicca Syndrom
Entzündung der Speicheldrüsen
Entzündung der Tränendrüsen

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Q

(SS)

Sicca-Syndrom (2)

A

Xerostomie + Xerophthalmie

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Q

(SS)

häufigste Entzündung der Speicheldrüsen

A

beidseitige Parotitis

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Q

(SS)

häufigste Entzündung der Tränendrüsen

A

Keratoconjunctivitis sicca

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Q

(SS)

häufigste systemische Symptome (3)

A

Fatigue
nicht-erosive Arthritis
Depression

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Q

(SS)

Labordiagnostik

A

Serologie

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Q

(SS)

Serologie (2)

A

unspezifische-
spezifische-

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Q

(SS)

unspezifische AK (2)

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A

ANA
RF

Q

(SS)

spezifische AK (2)

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A

anti-SSA (anti-Ro)
anti-SSB (anti-La)

Q

(SS)

apparative Diagnostik (3)

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A

Schirmer-Test
unstimulierter Gesamtspeichel-Test
Biopsie

Q

(SS)

Schirmer-Test: Befund

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A

↓ Tränensekretion

Q

(SS)

unstimulierter Gesamtspeichel-Test

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A

↓ Speichelsekretion

Q

(SS)

Biopsie: Durchführung

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A

aus der Schleimhaut der inneren Unterlippe

Q

(SS)

bioptischer Befund

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A

fokale lymphozytäre Sialadenitis

mit ↑ Lymphozytenzahl

Q

(SS)

Therapieplanung

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A

symptomatische-
ggf. immunsuppressive-

Q

(SS)

symptomatische Therapie (3)

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A

Augentropfen
Nasensprays
Kaugummi

(SS) immunsuppressive Therapie der Wahl

Glucocorticoide + ggf. andere Immunsuppressiva

(SS) Immunsuppressiva: Indikation

bei systemischer Beteiligung