Lupus Flashcards
3 defining characteristics of SLE (Like RA)
-SLE is chronic, progressive, inflammatory connective tissue disorde
SLE has periods of ______ and ______
remissions and exacerbations
onset of SLE?
acute or slow
is SLE fatal?
can be fatal from kidney damage
Systemic Lupus Erythematosus vs -Discoid Lupus Erythematosus
SLE = affect whole body DLE = affect skin
SLE patho
=Production of Antinuclear antibodies affect the cell nucleus contents
->Results in formation of immune complexes in serum and organs
–> Affect the organ directly or the vessels that provide organs with O2
–>leads Inflammation and destruction of vessels and organs
Nephrophilic - like kidneys, go in there and cause damage
SLE is ______philic
nephrophilic
SLE is more commin in males or females?
females
who has rapid progression of sxs- male or female?
male
patient population SLE is common in?
More common in African –American, Native –American, Latina and Asian- American females
age onset of SLE?
20-40 yrs
Assessment of SLE
- “Butterfly” rash
- Fever
- Fatigue
- Weakness
- Weight loss
- Anorexia
- Polyarthritis
- Osteonecrosis
- Muscle atrophy
- Myalgia
- Kidney issues* #1 reason people die of SLE
- Pleural effusions
- Pneumonia
- Pericarditis
- Reynaud’s phenomenon: Triggered by Cold and Stress
- Neurological problems
- Lymph enlargement
SLE is often diagnosed as what disease?
RA
diagnostics for SLE?
Skin biopsy (DSE) RF + ESR elevated ANA + Serum Complement (C3 & C4) Anti-SS-a , Anti-SS-b CBC/ CMP Pancytopenia **Follow kidney function
*similar to RA- no definitive diagnosis- based on ruling out other things, presentation, and auto-antibodies
pharmacology interventions for SLE?
Steroids
Immunosuppressive medications
Biologics (belimumab)
(risk for infection)
