Chapter 22 Respiratory System Flashcards

1
Q

Major Functions of Respritory System

A
  • Major Function
    • Supply O2 for cellular respiration
    • dispose of CO2
    • Done through the process of Respriation
  • Also functions in olfaction and speech
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2
Q

Process’ of Respriation

A
  • Respritory system
  • Pulmonary Ventilation (Breathing)
    • movment of air into and out of lungs
  • External respriation
    • O2 and CO2 exchange between lungs and blood
  • Circulitory System
  • Transport
    • O2 and Co2 in blood
      • Internal Respriation
    • O2 and CO2 echange between systemic blood vessels and tissues
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3
Q

Functional Anatomy

A
  • upper respritory system) consists of structures from the nose to larynx
  • lower respritory sytem) consists of the larynx and all the structures below it
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4
Q

The Nose

A
  • Functions
    • Airway for respriation
    • warms entering air
    • Filters and cleans air
    • Resonating chamber for Speech
    • Smell
  • External Nose
    • Root (area between eyebrows)
    • Bridge) dorsum nasi
    • Apex (top of nose)
    • Nostrils are surrounded by alae
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5
Q

Internal Nasal Cavity

A
  • Cavity that lies in and posterior to external nose
    • Divided by Nasal Septum (midline)
    • Posterior Nasal apatures) continious with nasal canal
  • Roof) Ethmoid and Sephnoid bones
  • Floor) formed by the palate
  • Nasal Vestibule) superior to the nostrils
    • Vibriasse (hairs) folter coarse particles
  • Olfactory Mucose) Contains Smell receptors
    • lies in olfactory epitheliam
  • Respritory mucose) lines most of the nasal cavity
    • Psuedostratifued ciliated columnar epitheliam with goblet cells
    • secrete lysozyme and defensisns
    • Cillia moves mucas to throat
  • Nasal Chonche) increase air turbulance
    • nasal meatus) grove inferior to conche
  • Paranasal Sinuses
    • Lighthen skull/ warm air
  • Functions of Nasal Mucosa and Chonche
    • Filter and heat air during inhalation
    • Reclaim heat and moisture during exhlation
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6
Q

Rhinitis

A
  • inflmation of nasal mucosa with excessive mucus production
    • caused by cold virusus, bacteria and various allergens
    • Nasal mucosa continuious with mucousa of respritory tract
    • Spreads From Nose > Throat> Chest
  • Sinisitus) when rhinitis spreads to paranasal sinuses
  • Sinus Headahe) Mucus/ infectious material blocks sinus passageways to nasal cavity creating pressure.
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7
Q

Pharynx

A
  • Muscular Tube from Skull to C6
    • connects nasal cavity/ mouth to larynx and esophagus
    • composed of skeletal muscle
  • Three regions
    • Nasopharynx. Oropharynx, Laryngopharynx
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8
Q

Nasopharynx

A
  • AIR passageway posterior to the nasal cavity
    • Lined by psudostratified columnar epithelium
  • Soft Plalte/ Uvula close nasopharynx during swallowing.
  • Pharyngeal Tonsil (Adenoids)
    • Located on Posterior wall
    • Traps and destroys pathogens
  • Pharyngotympanic (Auditory) Tubes
    • drains and equalizes pressure in middle ear; open into lateral walls of nasopharynx
    • Tubal Tonsil) ridge of pharengeal mucosa that protects against ear infections
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9
Q

Oropharynx

A
  • Passageway for food and air from anywhere between the soft palate and epiglottis
    • Lined by Stratified Squamous Epithelium
  • Isthmus of fauces (throat) opening to oral cavity
  • Palentine Tonsils) In lateral walls, posterior to oral cavity
  • Lingual tonsil) located on the posterior surface of the tongue
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10
Q

Laryngopharynx

A
  • Passageway for food and air
    • Lined with Stratified Squamous Epithelium
  • Posterior to upright epiglottis, extends to larynx where it is continuious with the esophagous
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11
Q

Lower Respritary System

A
  • Consists of two zones
  • Respritory Zones) sites of gas exhange
    • all microscopic structures (Respritory bronchioles, alveolar ducts, and alveoli
  • Conducting Zones) All respiratory passageways from nose to bronchioles.
    • provide conduits for air to reach gas exchange sites
    • Cleanse, Warm and Humidifys air
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12
Q

Larynx (Voice Box)

A
  • Attaches to the hyoid bone superiorly
    • opens into the laryngopharynx
    • Continuous with trachea
  • Functions
    • Provides and open airway
    • Routes air and food into proper channels
    • Voice Production) Houses vocal folds
  • Framwork of Larynx is arrangment of nine cartliges (Hayline cartlidge)
    • Thyroid Cartlidge with Larengal prominence (Adams apple)
    • Ring Shaped Circoid Cartlidge
    • Paired, Artenoid, Cuniform, and Corniculate Cartlidges
    • Arytenoid holds vocal folds
  • Epigliottis) ninth cartlidge made of elastic cartlidge
    • covers laryngeal inlet during swallowing
    • Initiates cough reflex to expel the substance.
    • Covered with taste-bud containing mucosa
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13
Q

Vocal Ligaments

A
  • Deep to laryngeal mucosa on each side
    • composed largley of elastic fibers
    • Attach artenoid cartlidge to thyroid cartlidge
  • Form core of Vocal folds (true vocal chords) which lack blood vessels
  • Glottis) opening between vocal folds
  • Folds vibrate to produce sound as air rushes from the lung
  • Vestibular Folds (False Vocal Cords)
    • superior to vocal folds
    • No part in sound production
    • Help to close glottis during swallowing
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14
Q

Epihtelium of Larynx

A
  • Superior Portion) Stratified Squamois Epithelium
  • Inferior Vocal Folds) Pseudostratified ciliated columnar epithelium
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15
Q

Voice Production

A
  • Speech Involves release of air while opening/closing glottis
  • Pitch) Determined by length/tension of vocal chords
    • Tenser chords = Faster Vibration =Higher Pitch
    • Boys larynx’s enlarge during puberty and their voice becomes deeper
  • Loundness) Depends upon force of the air
    • Yelling is louder than wispering
  • Chambers of pharynx, oral, nasal, and sinus cavities amplify and enhounce sound quality
  • Sound is “shaped” into language by muscles of pharynx, tounge, soft palate and lips.
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16
Q

Sphincter Functions of Larynx

A
  • Vocal Folds may act as a sphincter to prevent air passage
  • Vasalva’s manuever (Occurs during abdominal strain accociated shitting)
    • Glottis Closes to prevent exhalation
    • Abdominal muscles contract
    • Intra-Abdominal pressure rises
    • Helps to empty rectum or stabilize trunk durign heavy lifitng
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17
Q

Trachea (windpipe)

A
  • From Larynx into Mediastium
  • Wall composef of three layes plus a layer of hyaline cartlidge
    • Mucose) cilliated psudostratified epithelium with goblet cells
    • Submucosa) CT with seromucous glands that help produce mucus
    • Adventitia) Submucosa is supported by 16-20 C shaped rings of Hylane cartlidge encased by Adventitia
  • Trachealis Muscle) Connects Posterior Parts of Cartilage rings.
    • allows flexibality for food and air to pass
  • Carina) Where trachea branches into two main bronchi
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18
Q

Bronchi and Subdivisions

A
  • Bonchial Tree > Conducting Zone Structures > Respritory Zone Structures
  • Conducting Zone Structures
  • Trachea > Right or Left main (primary) bronchi
    • Each main bronchus enters hilum of one lung
    • Right bronchus wider, shorter and more vertical than the left
  • Main bronchi branches into Lobar (secondary) bronchi
    • Three on the right, two on the left
    • Each lobar bronchus supplies one lobe
  • Lobar bronchus branches into Segmental (tertiary) bronchi, Which divide repeateadly
  • Branches become smaller and smaller
    • Bronchioles) less than 1 mm in diameter
    • Terminal Bronchiles) smallest less than .5 mm
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19
Q

Conducting Zone Structural Changes

A
  • Support Structures Change
    • Carlige rings become irregular plates
    • In Bronchiles elastic Fibers relace cartlidge
  • Epthelium Type Change
    • Epithelium Changes from psuedostratified columnar to simple columnar then to simple cuboidal in terminal bronchiles
  • Amount of Smooth Muscle Increases
    • Allows Constriction
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20
Q

Respritory Zone Structures

A
  • Begins as Terminal Bronchioles > Respritory bronchioles > aveolar ducts > alveolar sacs > alveolar saccules
  • Avelolar sacs contain clusters of alvoli
    • 300 million make up most of lung volume
    • sites of gas exchange
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21
Q

Respritory Membrane

A

*

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22
Q

Alveoli

A
  • Three major types of cells are found in alveoli
    1. Single layer of squamous epithelium (type 1 alveolar cells) form alveolar wall/basment membrane
    2. Cuboidal Type II Alveolar Cells) secrete surfacent/ antimucrobial proteins
    3. Alveolar Macrophages) Keep alveolar surfaces sterile
  • Surrounded by same fine elastic fibers that surround entire bronchial tree
  • Open alveolar pores connect adjacent alveoli
    • equalizes air pressure throuought lung and provides alternate routes to diffrent alveoli.
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23
Q

Lungs

A
  • Surrounded by Plurae and connected to mediastium by vascular and bronchial attachments, called the root.
  • Anatomy
    • Costal Surface) Sides of lungs, Anterior, Posterior
    • Apex) Tip; deep to the clavicle
    • Base) Inferior surface; rests on diaphragm
    • Hilum) Site of entry/exit for blood vessls, bronchi, lymphatic vessels, and nerves
    • Stroma) Mostly elastic CT
  • Left Lung) Smaller than the right
    • cardiac notch) Concavity for heart
    • Oblique Fissure) Seperates superior and inferior LOBES
  • Right Lung) Larger
    • Horizontal and Oblique Fisures seperate the Superior, Middle, and Inferior lobes
  • Each Lobes contains a number of pyrmaid-shaped Bronchopulmonary Segments (10 on the right, 8-10 on the left)
  • Lobules) smallest divisons vivible to the naked eye
    • appear as hexagons
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24
Q

Blood Suply to the Lungs

A
  • Pulmonary Circulation (low pressure, high volume)
    • Pulmonary arteries) deliver venous blood for oxignation to pulmonary capilary networks
    • Pulmonary Veins) carry oxygnated blood from respiratory zones to the heart.
  • Bronchial Circularion (high pressure, low volume)
    • Bronchial Arteries) Provide oxygnated systemic blood to lung tissues
    • Arise from aorta and enter lungs at hilum
    • Provide blood supply to all lung tissues except alveoli.
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25
Q

Pleurae

A
  • Thin, double-layered serosa
  • Divides thoracic cavity into two compartments and mediastium
    • Parietal Pleura) On thoracic wall, superior face of the diaphragm, around the heart, between lungs
    • Visceral Pleura) on external lung surface
    • Pleural Fluid) fills pleural cavity. Lubricates lungs
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26
Q

Air Movment in Lungs

A
  • Volume changes cause pressure changes which casues air to move
  • Inspiration) gasses flow into lungs
  • Expiration) gasses exit lungs
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27
Q

Pressure Relationships in Thoracic Cavity

A
  • Atmospheric Pressure (Patm)
    • Pressure exeted by air surrounding body
    • 760 mmHg = 1atm
  • Intrapulmonaty Pressure (intra-alveolar) (Ppul)
    • Pressure in alveoli
    • Fluctuates with brething
    • Eventually equals Patm
  • IntraPleural Pressure (Pip)
    • Pressre in pleural cavity
    • Fluctuates with breathing
    • always less than Patm and Ppul
    • Fluid level must be minimal; pumped out by lymphatics
    • If accumulates > Positive Pip pressure > lungs collapse
  • Pressures described compared to Patm
      • =
  • Negative Pressure in Pleural space caused by
    • Elastic recoil of lungs pulling on plueral space
    • Surface tenion of alveolar fluid reduces alveolar size
28
Q

Pressure Relationships

A
  • Transpulmonary pressure
    • diffrence between intrapulmonary and intraplerual pressures
    • Ppul-Pip
    • Keeps airway open
    • Greater Transpulmonary Pressre= Larger lungs
29
Q

Pulmonary Ventilation

A
  • Mechanical Processes that depend on volume changes in thoracic cavity
    • Volume Changes> Pressure changes
    • Gasses flow to equalize pressure
  • Boyles law) Shows relationship of pressre anf volume of gas at a constant tempratue
    • P1V1=P2V2
30
Q

Inspiration

A
  • Active Processes
    • Inspiratory Muscles (Diaphragm moves inferiorly, External intercostals contact to lift rib cage)
  • Thoracic Volume Increases> Interpulmonary pressure drops (-1mmHg) and becomes less than the atmospheric pressure.
  • Lungs Streatched = More Volume = Airflow into lungs to compensate
  • Forced Inspiration
    • Occurs during vigourous excercise and in chronic obstructive pulmoanry diseases
    • Involves accesory mucles (Scalenes, Sternoclidomastoid muscles, Pec minor)
      *
31
Q

Expiration

A
  • Quiet Expiration
    • passive provess
    • Inspiratory mucles relax = thoracic volume decreases
    • Ppul rises to +1mmMG, air flows out
    • When Ppul > Patm the pressure gradient forces gases out of the lungs
  • Forced Expiration
    • Avtive Process
    • Uses abdominal mucles
32
Q

Airway Resistance

A
  • Friction) Major noneslatic source of resistance to gas flow; occurs in airways
  • Relationship between Flow (F), pressiure (P), and resistance (R) is
    • F= Change P/ R
    • Change P= Pressure gradient between atmosphere and alveoli
  • Airway resistance is normaly insigifigant
    • ​Large in diameter
    • Gets more resistant as the branches get smaller
  • Greatest resitance in Medium-Sized Bronchi
33
Q

Resistance Homeostatic Imbalance

A
  • Airway Reistance rises= more strenous breathing
  • Severe constriction or obstruction of the bronchiles
    • can prevent ventilation
    • can occur during asthma attacks
  • Epinephrine dilates bronchioles, reduces air resistance
34
Q

Alveolar Surface Tension

A
  • Surface tension
    • Attracts liquid molecules to one anohter at gas-liquid interface
    • Resists any force that tends to increase surface area of liquid
    • Water has a high surface tension; coats alveolar walls
  • Surfactant
    • Detergent-like lipid and protein complex produced by type II alveolar cells
    • Reduces surface tension of alveolar fluid/ discourages alveolar collapse
    • Infant respiritory Distress syndrome) caused by an insufficent quantity
35
Q

Lung Compliance

A
  • Lung compliance) the ability of a healthy lung to streatch
  • It is a measure of change in lung volume that occurs with a given change in transpumonary pressure
    • Δ CL= Δ VL / (Ppul – Pip)
    • Higher Lung Compliencee = Easier to expane
  • Depends on two factors
    • Disstenisibility of lung tissue
    • Alveolar Surface Tension
  • Diminished by
    • Chronic Inflimation or Infection
    • Fibrosis) Nonelastic scar tissue replaces lung tissue
    • Reduced production of sufactant
    • Decreased flexability of thoracic cage
  • The total compliance of the respiratory system is comprised of lung compliance and thoracic wall compliance.
36
Q

Respriritory Volumes

A
  • Tidal Volumes (TV) Amount of air inhaled or exhaled with each breath under resting conditions
  • Inspiratory Reserve Volume (IRV) Amount of air that can be forcefully inhaled after normal tidal inspiration
  • Expriatory Reserve Volume (ERV) ammount of air that can be forcefully exhaled after normal tidal expiration
  • Redidual Volume (RV) Ammount of air remaining in lungs after a forced expiration
37
Q

Respritory Capicaties

A
  • Inspiratory capacity (IC): Maximum amount of air thatcan be inspired after a normal tidal volume expiration
    • IC = TV + IRV
  • Functional residual capacity (FRC): Volume of air remaining in the lungs after a normal tidal volume expiration
    • FRC = ERV + RV
  • Vital capacity (VC): Maximum amount of air that can be expired after a maximum inspiratory effort
    • VC = TV+ IRV + ERV
  • Total lung capacity (TLC): Maximum amount of air contained in lungs after a maximum inspiratory effort
    • TLC = TV + IRV + ERV + RV
38
Q

Dead Space

A
  • Anatomical Dead Space
    • Some conducting respritory passgeways never contribute to gas exchange in alveoili
    • Air remaining in passageways about 1ml per pound of body weight
  • Alveolar Dead Space
    • Non-Functional Alveoli due to collapse or obstruction
    • added to anatomical dead space
  • Total Dead Space
    • Sum of all dead space
39
Q

Pulmnonary Function Tests

A
  • Spirometery) Most useful for evaluating loss in fucntion for following desieses and for respritory volume and capacities
    • Obstructive pulmonary desiese) increased air way resistance (Total lung capicity {TLC}, Functional Residual Capicity {FRC), and RV may increase)
    • Restrictive Disorders) Reduced TLC, (VC vital capicity, TLC, FRC, and RV decline)
  • Forced Vital Capicity (FVC) Measures ammount of gas expelled after deep breath
  • Forced Expiratory Volume (FEV) amount of gas expelled during specific time intervals of FVC test
    • Those with healty lungs can exhale 80% of FVC within one second
40
Q

Alveolar Ventilation

A
  • Dead space is normally constant
  • Rapid, shallow breathing decreases AVR
41
Q

Nonrespritory Air Movments

A
  • May modify normal respiratory rhythm
  • Most result from a reflex action (some voluntray)
    • ex) cough, sneeze, crying, laughing, hiccups, and yawns
42
Q

Dalton’s Law of Partial Pressures

A
43
Q

Henry’s Law

A
44
Q

Composition of Alveolar Gas

A
  • Alveoli contain more CO2 and water vapor than atmospheric air and much less O2
  • Diffrences reflect the effects of
    • gas exchange in the lungs
    • Humidification of air by conducting passages
    • Mixing of new and old alveolar gasses with each breath
45
Q

External Respiration

A
  • Exchange of O2 and CO2 across respiratory membrane
  • Influenced by
    • Thickness and surface area of respirtory membranes. 0.5-1 nanometer thick and gigantic surface area
    • Partial Presssure Gradients and Gas Solubilities. Drives O2 into venous blood and pulls CO2 out of venous blood
    • Ventilation- Perfusion Copling) adaquete blood flow reaches the alveoli (perfusion) and gas reaching alveoli (ventilation)
  • Ventilation-Perfusion Coupling
  • Influence of local Po2 on perfusion.
    • O2 high = arteioles dilate
    • O2 low = Arterioles constrict and redirect to high
  • Influence of Local PCO2
    • CO2 high= Bonioles dialate to eliminate faster
    • CO2 Low = Broncioles constrict
46
Q

Internal Respiration

A
  • Gas exhange in body tissues (capillary)
  • Partial pressure and diffusion gradients reversed
    • systemic O2 is lower than blood O2
    • CO2 moves from tissues to blood.
47
Q

O2 Transport in Blood

A
  • O2 Transport
    • molecular O2 carried in blood by hemoglobin in RBC’s (main conetent) and some in plasma
    • Oxyhemoglobin) oxygnated hemoglobin
    • Deoxyhemoglobin) no O2
  • Loading/ unloading of O2 causes a change in the shape of Hb
    • O2 binds, Hb affinity for O2 increases
    • O2 released, Hb affinity for O2 decreases
  • Rate of O2 loading/ unloading is influenced by
    • PO2, Temp, Blood PH, PCO2, and concentration of BPG
48
Q

Influence of O2 on hemoglobin saturation

A
  • In arterial blood.
    • PO2 = 100 mm Hg
    • Contains 20 ml oxygen per 100 ml blood. (20% of volume)
    • Hb is 98% saturated
    • Further increases in O2 does not increase saturation
  • In Venous blood
    • 15% volume is O2
    • Hb is 75% saturated
    • Venous reserve) substancial ammounts of O2 are aviable in venous blood if need be.
  • Temprature
    • Increase in Temp = lower affinity for hemoglobin absorbtion
    • Decrease in Temp = Higher affinity for hemoglobin absorption
  • BPG (2,3-bisphosphoglycerate)
    • reversibly binds with hemoglobin, levels rise when oxygen levels are chronically lwo
49
Q
A
50
Q

CO2 Transport

A
  • Transported in Three forms
  • 7-10% dissolved in plasma
  • 20% bound to globin of hemoglobin
    • does not interfere with O2 transport
    • Deoxygnated Hb combines faster with CO2 than oxygnated Hb does
  • 70% transported as Bicarbonate ions (HCO3-) in the plasma
  • Carbonic Acid (CO2 + H20 <> H2CO3 <> H+ + HCO3-
    • carbonic anhydrase
  • Systemic Caplilaries) HCO3 quickley diffueses from RBC’s into plasma
    • Chloride Shift) outrush of HCO3-
  • Pulmonary Capillaries
    • HCO3- moves into RBCs
51
Q

Haldane Effect

A
  • Lower PO2 and hemoglobin saturation = More CO2 carried in blood
    • reflects greater ability of reduced Hb to form carbaminohemoglobin
  • More CO2 enters blood = More O2 Dissociates from Hemoglobin
  • Bicarbonate Buffer System) Reists changes in blood pH
52
Q

Hypoxia

A
  • Inadequate O2 delivery to the tissues > Leads to cyanosis
    • Anemic Hypoxia) Too few RBC’s / Hb
    • Ischemic Hypoxia) Impaired circulation
    • Histotoxic Hypoxia) Cells unable to use O2
    • Hypoxemic Hypoxia) abnormal ventilation
    • Carbon monixide posioning) Binds to HB 200x better than O@
53
Q

Control of Respiration

A
  • Involves higher brain centers, chemoreceptors and other reflexes
  • Neural Controls
    • nuerons in medulla and pons
54
Q

Breathing Rate and Depth

A
  • Depth) determined by how activally the respritory center stimulates the resproritory muscles
  • Rate) Determined by how long the inspiratory center is active
  • Influence of PCO2
    • blood Co2 levels rise (hypercapina) CO2 accimulates in the brain
    • Carbonic acid dissociates releasing H+ to drop pH
    • Chemoreceptors detect higher pH and increase respritoty rate
55
Q

Hyperventilation

A
  • Increased depth and rate of breathing that exceeds the body’s need to remove CO2
    • Results in hypocapina
  • Apnea) breathing cessation from Low PCO2
56
Q

Influence of arterial pH

A
  • Can modify respritory rate and rhytm even of CO2 and O2 levels are normal
  • Aterial pH declines > respritory system increases rate to eliminate CO2
57
Q

Influence of Higher Brain Centers

A
  • Hypothalamic controls act through limic system to modify rate and respiration
    • ex) holding breath with anger
  • Raise in body temp increases respritory rate
  • Cortical controls) signals that directly bypass medullary controls
58
Q

Respritory Adjustments) Excercise

A
  • Hyperpnea) increased ventilation in response to metabolic needs (10-20x larger)
    • diffrent than hyperventilation (does not alter PCO2 levels)
  • Three nural factors increase ventilation as excercise begins
    • physcological stimuli) antipication of excercise stiumulates cortical motor activation
    • Excitatory impules to respritory centers from propioceptors
59
Q

Respiratory Adjustments) High Altotuide

A
  • altuides above 2400 meters (8000 feet) may
    • Lower PO2 levels
    • Headaches, shortness of breath, nausea, and dizziness
    • lethal cerebral and pulmonary edema in severe cases
  • Acclimatization) Adustments to high altuide
    • body becomes more responsive to increases in PCO2 and decline of PO@
    • Ventilation Increases > Lowers PCO2
    • Erythopoiten stimulates bone marrow to produce more RBC’s
60
Q

Chronic Obstructive Pulmonry Diesase (COPD)

A
  • Exemplified by chronic bronchitis and emphysems
  • Irreversiable decrease in ability to force air out of the lungs
  • Common Features)
    • history of smoking
    • Dyspnea) difficult breathing
    • Coughing and frequent pulmonary incfractions
    • Respritory Failure (hypoventilation)
61
Q
A
62
Q

Emphysema

A
  • Permanent enlargement of alveoli; destruction of alveolar walls; decreased lung elasticity
63
Q

Chronic Bronchitis

A
  • Inhaled Irritanats > Chronic Prodiction of excessive mucus > Inflamed and fibrosed lower respritory pathwways > Impaired lung ventilation
  • Frequent pulmonary infections
64
Q

Asthma

A
  • Characterized by coughing, dyspnea, wheezing, and chest tightness - alone or combination
    • Active inflammation of airways precedes
      bronchospasms
    • Airways thickened
65
Q

Tuberculosis (TB)

A
  • Infectious disease caused by Myobacterium Tuberculosos
  • Symptoms) Feaver, night sweats, weight loss, racking cough, coughing up blood
  • Treatment) anitbiotics
66
Q

Lung Cancer

A
  • Leading cuause of Cancer Deaths
  • 90% of all cases due to smoking
  • No Metastisis) surgery to remove lung tissue
  • Metastisis) radiation and chemotherapy
67
Q

Cystic Fibrosos

A
  • Abnormal, Viscous mucus clogs passageways and causes infections
    • Affects lungs, pancreatic ducts, and reproductive ductsz