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Epidemiology > Circovirus > Flashcards

Circovirus Flashcards

1
Q

Circovirus General Characteristics

A

ssDNA,, Icosahedral, no envelope, replicated in rapidly dividing cells, stenoxen, long life immunity, highly resistant

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2
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Most susceptible

A

1.5-4mo piglets

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3
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Target Organs

A
  • Lung, thymus, spleen, BM, liver, kidney, heart, brain
  • Dividing cells: Macrophages, APCs, Epithelium
  • Fetus: thymus&heart
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4
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Clinical Signs

A
  • Sudden death
  • Progressive weight loss
  • Non-specific CS
  • Enteric&respiratory signs
  • Aneamia
  • CNS signs
  • Jaundice , rough hair
  • Subclinical infection: dec. CD8+ ->recovery
  • PMWS: Lymphoid depletion, thymus atrophy, hepatitis, entreitis, pneumonia
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5
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Pathology & Histopathology

A
  • LNs: elnarged, hemorrhagic iguinal&mestenteric
  • Lungs: intestitial edema, pneumonia
  • General bad condition of carcass
  • White foci in kidney
  • Gastric ulcers
  • Hepatomagaly/atrophy, Jaundice, ascites
  • Strawberry heart with flaccid myocardium
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6
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Diagnosis

A

CS, PM, ELISA, PCR, IF

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7
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Treatment

A

No effective treatment!

Ab

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8
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Prevention & Immunity

A
  • Inactivated/recombinant vaccine (capsid protein)
  • No live vaccine!
  • Sow: protects from reproductional disorders, gives enough protection to piglets
  • Piglets:after weaning

*Colostral Ab: 4-12w

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9
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Pathogenesis

A

Oronasal -> replicates in monocytes in nasal mucosa >lung->thymus, spleen-> BM, liver, kidney heart, brain

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10
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Most susceptible

A

30-100kg pigs
>1.5mo
*wild boars,ru, rodents are reservoirs

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11
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Occurence

A

Sporadic

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12
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Occurence

A
  • Epidemic in Europe and Asia

* Sporadic in North America

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13
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Spread

A

Oral/nasal/sexual

Contact with sick animal, respiratory secertions, saliva, urine, feces, sperm

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14
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Spread

A

Oral/nasal/sexual

Contact with sick animal, respiratory secertions, saliva, urine, feces, sperm

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15
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Pathogenesis

A

Not fully understood

*Type III hypersensitivity -Immunocomplex deposition in skin, kidney, BV

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16
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Clinical signs

A
  • Progressive weight loss
  • Multifocal, circular red skin lesion->darken->scar
  • Hemorrhages throughout the body
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17
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Pathology

A
  • Hemorrhagic enlarged grayish kidneys.
  • Thrombosis, systemic narcotizing vasculitis
  • Exudative glomerulonephritis
  • Bronchopneumonia
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18
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Diagnosis

A

CS, PM, ELISA, PCR, IF

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19
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Treatment

A

No effective treatment

Ab

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20
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Prevention & Immunity

A
  • Inactivated/recombinant vaccine (capsid protein)
  • No live vaccine!
  • Sow: protects from reproductional disorders, gives enough protection to piglets
  • Piglets: after weaning
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21
Q

PRDC: Porcine Respiratory Disease Complex

Most susceptible

A

4-7mo

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22
Q

PRDC: Porcine Respiratory Disease Complex

Clinical Signs

A

*Slow growth
*Decreased feed conversion
*Fever, Lethargy
*Respiratory symptoms
(coughing, heavy breathing)

23
Q

PRDC: Porcine Respiratory Disease Complex

Pathology & Histopathology

A

Interstitial Bronchopneumonia

Peribronchial fibrosis

24
Q

PRDC: Porcine Respiratory Disease Complex

Diagnosis

A

CS, PM, ELISA, PCR, IF

25
Q

PRDC: Porcine Respiratory Disease Complex

Treatment

A

No effective treatment!

26
Q

PRDC: Porcine Respiratory Disease Complex

Prevention & Immunity

A
  • Inactivated/recombinant vaccine (capsid protein)
  • No live vaccine!
  • Sow: protects from reproductional disorders, gives enough protection to piglets
  • Piglets: after weaning
27
Q

PRF: Porcine Reproductive Failure

Most susceptible

A

Pregnant sows

28
Q

PRF: Porcine Reproductive Failure

Target organs

A

Placental Crossing!

*Targets foetal myocardium, liver and macrophages

29
Q

PRF: Porcine Reproductive Failure

Clinical Signs

A

<70d: SMEDI

>70d: reproductive disorders, enlarged heart of fetus, abortion

30
Q

PRF: Porcine Reproductive Failure

Pathology

A

Foetal myocardiatis

Extensive fibrosis in the heart of foetus

31
Q

PGE: Porcine Granulomatous Enteritis

Most susceptible

A

1.5-2mo piglets

32
Q

PGE: Porcine Granulomatous Enteritis

Clinical Signs

A

Diarrhoea (initially yellow, later dark)

33
Q

PGE: Porcine Granulomatous Enteritis

Pathology

A

Microscopic granules in the intestines

34
Q

PNL: Porcine Necrotising Lymphadenitis

Most susceptible

A

Piglets FROM weaning

35
Q

PNL: Porcine Necrotising Lymphadenitis

Clinical Signs

A

Diarrhoea, Incoordination

36
Q

PNL: Porcine Necrotising Lymphadenitis

Pathology

A

Folliculair lymphoid necrosis

37
Q

PCT: Porcine Congenital Tremor

Most susceptible

A

Piglets UNTIL weaning

38
Q

PCT: Porcine Congenital Tremor

Clinical Signs

A

Shaking, Phtisis

39
Q

PCT: Porcine Congenital Tremor

Pathology

A

Demyelination

40
Q

PEE: Porcine Exudative Epidermitis

Most susceptible

A

5-35do piglets

41
Q

PEE: Porcine Exudative Epidermitis

Clinical Signs

A

Epidermitis

42
Q

PEE: Porcine Exudative Epidermitis

Pathology

A

Pyoderma

43
Q

Acute Haemorrhagic Diarrhoea

Clinical Signs

A

Vomiting, Diarrhoea, Lethargy, Vasculitis,

Thrombocytopaenia

44
Q

Psittacine Beak and Feather Disease (PBFD)

Most susceptible

A

Psittacine Birds (Also Goose, Duck, Pigeon, Ostrich, Canary)

< 3yo

45
Q

Psittacine Beak and Feather Disease (PBFD)

Occurrence

A

Australia-> worldwide

46
Q

Psittacine Beak and Feather Disease (PBFD)

Spread

A

Contact with infected animal. feces, fomites, respiratory secretions

  • infected feather follicle
  • vertical via egg/sperm
47
Q

Psittacine Beak and Feather Disease (PBFD)

Pathogenesis

A

PO->intestine(respiratory)->viraemia-> all organs

Lymphoid organs especially

48
Q

Psittacine Beak and Feather Disease (PBFD)

Primary Replication

A

Intestine

Incubation: 7-10d

49
Q

Psittacine Beak and Feather Disease (PBFD)

Target Organs

A

All organs

*Lymphoid organs: *BM, Thymus, Bursa fabricii -> immunosupression

50
Q

Psittacine Beak and Feather Disease (PBFD)

Clinical Signs

A

< 3wo: Anaemia-Dermatitis Syndrome (anorexia, retarded growth and death),
* dec. productivity, secondary infection
*Secondary bacterial infection
>3wo: no disease/mild immunosuppression

51
Q

Psittacine Beak and Feather Disease (PBFD)

Pathology & Histopathology

A
  • Haemorrhages in gizzard and proventriculus
  • Atrophy of the thymus and Bursa Fabricii
  • Pale haemorrhagic tissues
52
Q

Psittacine Beak and Feather Disease (PBFD)

Diagnosis

A

CS, PM, lymphoid cultures, PCR

53
Q

Psittacine Beak and Feather Disease (PBFD)

Treatment

A

No effective treatment!

Ab

54
Q

Psittacine Beak and Feather Disease (PBFD)

Prevention and Immunity

A

Vaccine (live, attenuated) before laying period -> maternal immunity

Epidemiology (16 decks)

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