M3: L-8 Flashcards
For what substitution reaction mechanism is a good leaving group more important?
SN1
What conditions are used to create better leaving groups from OH and OR electrophiles?
acidic conditions ( pronation)
For which substitution reaction mechanism is having a nucleophile more important?
SN2
What are the ideal solvent conditions for SN1 reaction mechanisms?
- polar
- able to H bond
What are the ideal solvent conditions for SN2 reaction mechanisms?
- Not able to H bond
What determines which elimination reaction mechanism occurs?
Base strength ( strong base = E2) (weak base = E1)
Explain the E1 reaction mechanism:
- Electrophile leaves and generates a carbocation intermediate
- A base (H20 most abundant) removes H+ to form C=C
What controls the ratio of E1: SN1 reactions occurring
Relative rates of the two alternative fast steps
Explain the E2 reaction mechanism:
The electrophile leaves at the same time the base takes the H+