1.17 Degradation of porphyrines Flashcards
1
Q
Where does porphyrin degradation occur?
A
- Mononuclear phagocyte system
- Spleen
- Liver
- Bone marrow
2
Q
Draw the degradation of Haemoglobin
A
3
Q
High conc. of Bilirubin in the blood leads to…
A
Icterus
- Prehepatic
- Hepatic
- Posthepatic
4
Q
Myoglobin
A
- 1 Haem + 1 polypeptide chain
- O2 binding protein of skeletal muscle
5
Q
Paralytic myoglobinuria
A
- Seen in heavy horses
- Glycogen-rich diet with Ø work: Glycogen storage ↑
- pH ↓
- Muscle cell damage
6
Q
Cytochromes
- Function
A
- Respiratory chain
- Cytochrome p450 → detoxification (liver)
7
Q
Catalase + Peroxidase are located in…
A
Peroxisomes
8
Q
The function of catalase and peroxidase
A
Antioxidant control
Prevents: Fe2+ → Fe3+
9
Q
Catalase catalyses which reaction?
A
2H2O2 → 2H2O + O2
10
Q
Peroxidase catalyses which reaction?
A
H2O2 + H2-substrate → 2H2O + Substrate
11
Q
Draw iron metabolism
A
DMT-I = Divalent metal transporter I
12
Q
What regulates Ferroportin?
A
Hepcidin (-)
