22. Biochemistry of cholesterol Flashcards
1
Q
Give the structure of cholesterol
A
2
Q
Draw cholesterol synthesis
A
3
Q
Cholesterol synthesis is located in…
A
- Liver
- Gonads
- Intestine
Cytoplasm
4
Q
Importance of cholesterol
A
- Membrane constituent
- Precursor for bile salts + steroids
5
Q
Cholesterol synthesis: Regulation
A
HMG-CoA reductase
- Dietary cholesterol (-)
6
Q
Storage form of cholesterol
A
Esterified by palmitic or linoleic acid
7
Q
How is cholesterol transported?
A
Esterified by FAs of lecithin
8
Q
When does cholesterol form gall stones?
A
When solubilised in bile by bile acids + lecithin
9
Q
Draw the synthesis of the primary bile acids
A
10
Q
Bile acids can be conjugated with…
A
Either:
- Glycine → Glycocholic acid
- Taurine → Taurocholic acid
11
Q
Draw the formation of Glycocholic acid
A
12
Q
The biochemical function of bile acids
A
- Emulsification of fats → So lipase can degrade them
- Solubilisation + transport of lipids → Micelle formation
- Acting as hormones
