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MBB 428 - Microbial Pathogenesis > 12. Hepatitis C > Flashcards

12. Hepatitis C Flashcards

1
Q

Genome of hep C?

A

(+)ssRNA, enveloped

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2
Q

Is the viral poylmerase packaged with Hep C?

A

No

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3
Q

Hep C circulates in the bloodstream as ____________

A

lipo-viro-particle

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4
Q

Current Hep C therapy? What’s it made of?

A

Harvoni

Ledipasvir + Sofosbuvir

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5
Q

What is Ledipasvir (type of antiviral)?

A

NS5A-inhibitor

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6
Q

Function of Hep C NS5A protein?

A

Regulator of replication and viral assembly

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7
Q

Function os Hep C NS4A protein?

A

NS3 protease co-factor

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8
Q

What is Hep C NS3?

A

A serine protease and helicase, assembly factor

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9
Q

Hep C enters the cell via ______- and ________-mediated endocytosis

A

receptor- and clathrin-mediated

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10
Q

How does Sofosbuvir function as an antiviral?

A

Nucleotide NS5B inhibitor = compete with uridine and prevents strans synthesis => chain terminator

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11
Q

How does Ledipasvir function as an antiviral?

A

NS5A inhibitor = may inhibit hyperphosphorylation required for viral production

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12
Q

People with the ___ genotype have a stronger immune response to Hep C (more likely to be cured)

A

CC

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13
Q

Difference between nucleoside and non-nucleoside inhibitors?

A

NI act at catalytic site = incorporation causes chain termination

NNIs bind to allosteric sites = conformational change of catalytic site

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14
Q

Side effect of Ribavirin?

A

Haemolytic anemia

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15
Q

Where do Hep C nucleocapsids form?

A

At the ER-derived membrane

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16
Q

As the Hep C particle transits thru the secretory pathway, ____ and ___ are post-translationally modified

A

E1 and E2

17
Q

Function of Hep C NS5B protein?

A

RNA-dependent RNA pol

18
Q

Function of Hep C NS2 and p7?

A

Support viral particle production

19
Q

How do protease inhibitors function as HCV antivirals

A

Prevent cleavage of polyprotein = no translation of viral polymerase

MBB 428 - Microbial Pathogenesis (28 decks)

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