26. S.aureus therapy

Question 1

What is CA-MRSA?

Answer 1

Community-acquired S. aureus

Question 2

What is the most prevalent CA-MRSA isolate in the US?

Answer 2

US300

Question 3

Conventional treatment for MRSA?

Answer 3

Vancomycin

Question 4

S. aureus can survive in what kind of cell?

Answer 4

Neutrophils

Question 5

Antibody-antibiotic conjugate (AAC) consists of what?

Answer 5

• Anti-S.aureus Ab
• Antibiotic
• Cathepsin-cleavable linker

Question 6

Mechanism of action of rifamycin?

Answer 6

Blocks RNA synthesis by inhibiting DNA-dependent RNA pol

Sterically blocking extension of nascent RNA chain