4. Poliovirus (poliomyelitis) Flashcards
1
Q
Where in the body does polio act?
A
Gut (enterovirus)
2
Q
Polio genome?
A
(+) ssRNA
3
Q
4 polypeptides found in polio?
A
VP1, VP2, VP3, VP4
4
Q
How does polio enter the body?
A
Fecal-oral route
5
Q
Polio replicates in the _________ and migrates to the _______
A
pharynx; SI
6
Q
First polio vaccine developed = ?
A
Salk vaccine; completely inactivated form
7
Q
Where in the cell does polio replicate?
A
Cytoplasm - surface of ER-derived vesicles
8
Q
Poliovirus receptor (PVR) is also known as what?
A
CD155
9
Q
Poliovirus family?
A
Picornaviridae
10
Q
Poliovirus genus?
A
Enterovirus
11
Q
Function of polio VPg protein?
A
Attaches to 5’ end
12
Q
Which polio polyprotein sections are cleaved to form viral proteases? What do they form?
A
P2 and P3
VPg + enzymes involved in genome replication
