Class III (Antiarrythmics) Potassium Channel Blockers

Question 1

Class III agents exert antiarrhythmic effects through which of the following mechanisms:

Answer 1

Blockade of Potassium channels in Phase 3 prolonging action potential duration

Question 2

Amiodarone is a class III antiarrhythmic that also exert which of the following effects from other antiarrhythmic classes:
(Select all that apply)

Answer 2

Na Channel Blockade
Alpha Adrenergic Blockade
Beta Adrenergic Blockade
Ca Channel Blockade

Question 3

Sotalol is also a class III antiarrhythmic with which of the following effects:

Answer 3

Beta Adrenergic antagonism

Question 4

Amiodarone has highly variable and erratic parenteral absorption and distribution. True or False?

Answer 4

False

Question 5

Amiodarone has antiarrhythmic and proarrhythmic effects. It’s proarrhythmic effects are a result of:

Answer 5

Class I effects

Question 6

Amiodarone has numerous drug interaction including which of the following:
(Select all that apply)

Answer 6

Potentiate effects of Warfarin
Increased pro-arrhythmic effects with QT prolonging medications
Increase concentration of digoxin

Question 7

The following are adverse outcomes associated with Amiodarone, except:

Answer 7

Hypotension