Pathogenesis

Question 1

Does asymptomatic mean nonpathogenic?

Answer 1

No

Question 2

Pathogenicity

Answer 2

The ability of one organism to cause disease in another

Question 3

Hypoplasia

Answer 3

Localized slowed growth frequently leading to mosaicism

Question 4

How can viruses cause damage?

Answer 4

Directly due to replication
Cell transformation caused by viruses
Damage from immune activation or suppression

Question 5

Cytopathic effects

Answer 5

Altered cells which lead to localized or systemic disease

Question 6

Transformation

Answer 6

Change in morphological, biochemical, or growth parameters of a cell

Mediated by oncogenes encoded by viral genomes

Question 7

Transformation effects

Answer 7

Loss of anchorage dependence - cells float off
Loss of contact inhibition - keep growing even when no room
Decreased requirements for growth - constitutive growth and replication

Question 8

Caveat of oncogenes for RNA viruses

Answer 8

Must have DNA stage (retroviruses) but can encode host oncogenes

Question 9

DNA viruses and oncogenes

Answer 9

Unique to the virus genome