Dani - ch 6

Question 1

chronic inflammation

• follows ___ inflammation
• ____ attacks of acute inflammation
• begins ____

Answer 1

acute
repeated
insidiously

Question 2

immune response of chronic inflammation

- presence of 3 cells

Answer 2

macrophage
lymphocyte
plasma cells

Question 3

phagocytosis of chronic inflammation is doen by ____ activated by gamma interferon, Ig, and complement

Answer 3

macrophages

Question 4

repair of damage tissue from chronic inflammation done by new ___ ___ and proliferation of ___ and ___

Answer 4

blood vessels
fibroblasts
fbrosis

Question 5

differences from acute inflammation

• ___ onset
• ___ course
• vasodilation: mild (no ___ or ___)
• scanty exudate: no ____
• chronic inflammatory cells: __ and ___ lymphocytes, plasma cells and ____

Answer 5

insidious
progressive
redness;hotness
edema
B and T; macrophages

Question 6

immune activation of monocytes to phagocytize

Answer 6

gamma interferon

Question 7

non-immune activation of monocytes to phagocytize

Answer 7

bacterial endotoxin

Question 8

morphology of monocytes in chronic inflammation

• ___ size of cells
• more ___ metabolism
• more ____ enzymes

Answer 8

larger
active
lysosomal

Question 9

monocytes are ___ cells, kills bacteria by ___ dependent and ____ mechanisms

Answer 9

scavenger
oxygen
independent

Question 10

___ cells: produce antibodies against foreign antigens or modified tissue antigen

Answer 10

plasma

Question 11

___: mobilized in both antibody ad cell mediated immune reactions

Answer 11

lymphocytes

Question 12

___ lymphocytes are activated in antibody immune reactions and ___ lymphocytes are activated in cell mediated immune reactions

Answer 12

B

T

Question 13

____: immune reaction mediated by IgE and parasitic infection

Answer 13

eosinophils

Question 14

___: may persist in chronic inflammation

Answer 14

neutrophils

Question 15

granulomatous chronic inflammation: presence of ____

Answer 15

granuloma

Question 16

2 types of granulomatous chronic inflammation cells

Answer 16

epitheloid

giant

Question 17

epitheloid cells

• essential for ___
• are ____ macrophages
• abundant __ ___ cytoplasm
• elongated ____ nucleus

Answer 17

diagnosis
modified
pale pink
vesicular

Question 18

giant cells

• ____, 40-50
• coalescence of ___
• __ or more nuclei
• ___ and foreign body ___ cell

Answer 18

large
macrophages
20
langhan's
giant

Question 19

granulomatous chronic inflammation

• central ___
• peripheral rim of 4 cells

Answer 19

necrosis
lymphocytes
plasma cells
neutrophils
collagen fibers

Question 20

granulomatous chronic inflammation occurs in 2 types of diseases

Answer 20

infections

chemical

Question 21

non-granulomatous chronic inflammation

- ___ inflammatory cells are scattered ___ throughout the tissue

Answer 21

chronic

throughout

Question 22

___ and ___ are common in non-granulomatous chronic inflammation

Answer 22

necrosis

fibrosis

Question 23

systemic manifestation of inflammation:

- heat regulating center in ____ –> ___ stimulation –> ___ of skin vessels –> ___ heat loss –> ____

Answer 23

hypothalamus
sympathetic
vasoconstriction
decreased
fever

Question 24

fever is caused by liberation of pyrogens ___ and ___

Answer 24

IL-1 and TNF

Question 25

heat regulating center in hypothalamus act directly or by local production of ____

Answer 25

prostaglandins

Question 26

systemic manifestation of inflammation:

leukocytosis:
- immediate release from ___ ___
- prolonged infection stimulates bone marrow ___ cells

Answer 26

bone marrow

stem

Question 27

systemic manifestation of inflammation:

• sleepiness
• ___ blood pressure
• ___ fibrinogen
• __ erythrocyte sedimentation rate

Answer 27

decrease
increase
increase

Question 28

systemic manifestation of inflammation:
failure of localization (lymph involvement)
- regional lymph nodes (__ line of defense) –> failure of localization –> reticuloendothelial cells (___ line of defense)

Answer 28

2nd

3rd