What is dyspepsia?
Burning epigastric pain
Pathology in which section of the gut produces epigastric pain?
Infection with which bacteria can cause dyspepsia?
Which class of drugs can cause peptic ulcers associated with dyspepsia?
NSAIDs (aspirin, ibuprofen)
What are some organic causes of dyspepsia?
75% of dyspepsia cases are ___.
no clear cause
Which functional gut disorder can cause dyspepsia?
Irritable bowel syndrome
What is a common disease causing organic dyspepsia?
Peptic ulcer disease
Where is pain associated with peptic ulcers felt?
Where can pain associated with peptic ulcers radiate?
What can aggravate dyspepsia caused by peptic ulcers?
Which bacteria causes peptic ulcer disease?
What drugs cause peptic ulcer disease?
When do people tend to acquire H. pylori?
H. pylori is a Gram (positive / negative) (cocci / bacillus).
Gram -ve bacilli
Where do peptic ulcers arise?
1% of those infected with H. pylori go on to develop gastric ___.
Which hormones stimulates the release of hydrochloric acid from parietal cells?
Which cells release gastrin?
When food enters the stomach, the pH ___.
Increasing pH causes an (increase / decrease) in the amount of gastrin secreted by G cells.
H. pylori related gastritis causes an increase in the secretion of ___ by _ cells.
What is a consequence of this?
gastrin , G cells
Increased HCl secretion leading to gastric / duodenal ulcers
Ulcers which burrow into arterioles are at a high risk of ___.
Gastric ulcers can be ___ or ___.
acute , chronic
Large, irregular looking gastric ulcers are indicative of ___.
Which enzyme is used to test for H. pylori infection?
What material can be tested for H. pylori antigens?
Which enzyme, expressed by H. pylori, can be used to test for its presence?
What sort of test is commonly used to detect H. pylori in the stomach?
Urease BREATH test
All patients with peptic ulcer disease are given which class of drug?
PPIs (e.g omeprazole)
All patients with peptic ulcer disease are tested for the presence of which bacteria?
Which drugs should be withdrawn if a patient has peptic ulcer disease?
Which triple therapy is used to eradicate H. pylori?
PPI + 1g Amoxicillin BD + Clarithromycin 500mg BD
PPI + 400mg Metronidazole BD + Clarithromycin 250mg BD
H. pylori eradication therapy tends to cause ___ and ___.
Why may a peptic ulcer patient develop anaemia?
What may happen to the wall of the stomach / duodenum if a peptic ulcer penetrates it deeply?
Patients with untreated peptic ulcers may develop GI tract ___ due to fibrosis.