13: Dyspepsia and peptic ulcer disease Flashcards Preview

Gastrointestinal Week 3 2016/17 > 13: Dyspepsia and peptic ulcer disease > Flashcards

Flashcards in 13: Dyspepsia and peptic ulcer disease Deck (37):
1

What is dyspepsia?

Burning epigastric pain

2

Pathology in which section of the gut produces epigastric pain?

Foregut

3

Infection with which bacteria can cause dyspepsia?

H. pylori

4

Which class of drugs can cause peptic ulcers associated with dyspepsia?

NSAIDs (aspirin, ibuprofen)

5

What are some organic causes of dyspepsia?

Peptic ulcers

Drugs (NSAIDs)

Gastric cancer

6

75% of dyspepsia cases are ___.

idiopathic

no clear cause

7

Which functional gut disorder can cause dyspepsia?

IBS

Irritable bowel syndrome

8

What is a common disease causing organic dyspepsia?

Peptic ulcer disease

9

Where is pain associated with peptic ulcers felt?

Epigastrium

10

Where can pain associated with peptic ulcers radiate?

Back

11

What can aggravate dyspepsia caused by peptic ulcers?

Eating

12

Which bacteria causes peptic ulcer disease?

H. pylori

13

What drugs cause peptic ulcer disease?

NSAIDs

14

When do people tend to acquire H. pylori?

Childhood

15

H. pylori is a Gram (positive / negative) (cocci / bacillus).

Gram -ve bacilli

16

Where do peptic ulcers arise?

Stomach

Duodenum

17

1% of those infected with H. pylori go on to develop gastric ___.

cancer

18

Which hormones stimulates the release of hydrochloric acid from parietal cells?

Gastrin

Histamine

19

Which cells release gastrin?

G cells

20

When food enters the stomach, the pH ___.

increases

21

Increasing pH causes an (increase / decrease) in the amount of gastrin secreted by G cells.

increase

22

H. pylori related gastritis causes an increase in the secretion of ___ by _ cells.

What is a consequence of this?

gastrin , G cells

Increased HCl secretion leading to gastric / duodenal ulcers

23

Ulcers which burrow into arterioles are at a high risk of ___.

bleeding

24

Gastric ulcers can be ___ or ___.

acute , chronic

25

Large, irregular looking gastric ulcers are indicative of ___.

cancer

26

Which enzyme is used to test for H. pylori infection?

Urease

27

What material can be tested for H. pylori antigens?

Faeces

28

Which enzyme, expressed by H. pylori, can be used to test for its presence?

Urease

29

What sort of test is commonly used to detect H. pylori in the stomach?

Urease BREATH test

30

All patients with peptic ulcer disease are given which class of drug?

PPIs (e.g omeprazole)

anti-secretory

31

All patients with peptic ulcer disease are tested for the presence of which bacteria?

H. pylori

32

Which drugs should be withdrawn if a patient has peptic ulcer disease?

NSAIDs

33

Which triple therapy is used to eradicate H. pylori?

PPI + 1g Amoxicillin BD + Clarithromycin 500mg BD

or

PPI + 400mg Metronidazole BD + Clarithromycin 250mg BD

34

H. pylori eradication therapy tends to cause ___ and ___.

nausea

diarrhoea

35

Why may a peptic ulcer patient develop anaemia?

Bleeding

36

What may happen to the wall of the stomach / duodenum if a peptic ulcer penetrates it deeply?

Perforation

37

Patients with untreated peptic ulcers may develop GI tract ___ due to fibrosis.

obstruction