Collagen Flashcards
the first stage of collagen synthesis and the translation of collagen chains (preprocollagen)
synthesis
the second stage of collagen synthesis and is the ____ of specific proline and lysine residues
hydroxylation
hydroxylation requires what vitamin deficiency?
vitamin C deficiency
the third stage of collagen synthesis and is the ____ of pro-alpha-chain hydroxylysine residues and formation of procollagen
glycosylation
the fourth stage of collagen synthesis and is the ___ of procollagen to extracellular space
exocytosis
the fifth stage of collagen synthesis and is the cleavage of disulfide-rich terminal regions of procollagen
proteolytic processing
the sixth stage of collagen synthesis and is the assembly of collagen in fibrils and aligns for cross-linking
assembly and alignment
the last stage of collagen synthesis and is the reinforcement of staggered tropocollagen molecules by covalent lysine-hydroxylysine cross-linkage to make collage fibrils
cross-linking
most abundant protein in the human body
collagen
production in osteogenesis imperfecta type I
type I collagen
deficient in vascular type of Ehlers-Danlos syndrome
type III collagen
defective in alport syndrome; targeted by autoantibodies in goodpasture syndrome
type IV collagen
