Flashcards in 132 GI Pathogens Deck (20):
most common causes of food-borne illnesses in US - bacterial? parasite? viral?
Giardia lamblia (parasite)
inflammatory diarrhea vs noninflammatory diarrhea
inflamm - mucous or blood from mucosa tissue destruction by pathogen;RBC, WBC + fever + incubation period of 2-4 days
noninflamm - watery stool without blood; due to toxins/virus NOT invasion into musosa; shorter incubation (1-12 hours); No fever
noninflammatory diarrhea - most common causes
Enterotoxigenic E Coli
vibro cholerae - shape/appearance? where does it live in environment? What are the types?
gram negative rod ("comma shaped")
salt water in marine crustaceans
2 biotypes - El Tor (less severe) and Classic
cholera toxin - what encodes? what type of toxin? what does it increase in the cell? what does this activate?
encoded by phage
AB toxins (A is active, B is binding subunit)
activates enzyme increasing cAMP
activates CFTR channel --> increased Cl secretion and decreased Na uptake
cholera - clinical disease; death? how acquired? stool appearace? fever? oxidase +/-? treatment?
severe dehydration and death in 12 hours --> need massive amount of IV fluid
acquired via raw fish or water
stool is watery with mucus flecks
IV + antibiotics
Anaerobic gram + bacillus
food poisoning --> diarrhea + cramping without vomiting
<24 hours - self limited
dont need antibiotics
found in what?
Gram + rod
2 toxins --> vomitting + watery diarrhea
toxins found in rice
< 24 hours --> dont need antibiotics
symptoms and length?
found in what?
food poisoning from heat stable toxins (A-->E)
cause wide spread outbreaks
vomiting + diarrhea < 10 hours
creams, potato salad, mayo
illness is from toxin so no antibiotics
who gets infected?
common world wide - everyone gets infected
vomiting then diarrhea w/ fever (exception to noninflam diarrhea rule)
**Everyone rotates through rotovirus and rotates through symptoms (vomiting --> diarrhea + fever)
Fecal-oral + contaminated food/water
nausea, vomiting, diarrhea
24-48 hours (no treatment required)
who gets it?
symptoms and duration?
fecal - oral --> campers
2 forms - trophozoites + cyst in environment
diarrhea, bloating, gas
Rx - metronidazole, furazolidone
traveler's diarrhea - common cause and course?
enterotoxigenic E Coli is most common cause
short lived and self limited
enterhemorrhavic E Coli
type of diarrhea?
gram negative rods (closely related to E Coli)
tolerates stomach acid --> fingers, food, flies, feces, fomites (forks)
invades colon via M cells --> enterocyte spreading via host actin tails (like listeria)
mild watery diarrhea --> blood and pus w/ pain diarrhea
what does it cause?
gram negative bacillus
food poisoning - chicken and eggs
appearance and stain?
type of diarrhea? what other disease?
curved gram negative rod "sea gull"
bloody diarrhea followed by Guillain-Barre syndrome on occasion (ascending neuropathy --> respiratory failure)
animals - food, poultry
gram negative rod
blood transfusion spread
gram + rod
antibiotic assoicated diarrhea --> antiobtiocs allow organism to get a foot hold --> pseudomembrance formation