Flashcards in 122b histo of gastric disorders Deck (11):
Gastric mucosa compartments and contents
foveolar compartment - surface epithelial cells
glandular compartment - varies by region
includes: mucous, parietal, chief, enteroendocrine
what limits injury to gastric mucus layer and determines how quickly repair occurs (excluding bicarb, tight jxn, mucus, blood supply)?
muscularis mucosa - hours/days vs weeks if not intact
Acute gastritis causes
stress (trauma, virus, surgery)
NSAIDS (lower PGE)
burns (Curling's due to low plasma volume)
brain injury (Cushing increase vagal stimulation)
acute gastritis pathogensis
mucosal damage --> inflammation and back flow of H+ into mucus layer
acute gastritis endoscopic findings
red, swollen mucosa with erosions/hemorrhages
Chronic Gastritis - general pathogenesis
chronic inflammation in lamina propria --> mucosal atrophy and intestinal metaplasia
autoimmune gastritis - pathogenesis and what this causes
autoantibodies against parietal cells (--> hypochlorhydria) and IF (-->pernicious anemia)
what part of the stomach is affected in autoimmune gastritis?
body and fundus
diffuse antral chronic gastritis - cause?
what is seen with diffuse antral chronic gastritis?
lymphoid follicles - not normally present in stomach