122b histo of gastric disorders Flashcards Preview

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Flashcards in 122b histo of gastric disorders Deck (11):
1

Gastric mucosa compartments and contents

foveolar compartment - surface epithelial cells

glandular compartment - varies by region
includes: mucous, parietal, chief, enteroendocrine

2

what limits injury to gastric mucus layer and determines how quickly repair occurs (excluding bicarb, tight jxn, mucus, blood supply)?

muscularis mucosa - hours/days vs weeks if not intact

3

Acute gastritis causes

stress (trauma, virus, surgery)
NSAIDS (lower PGE)
alcohol
uremia
burns (Curling's due to low plasma volume)
brain injury (Cushing increase vagal stimulation)

4

acute gastritis pathogensis

mucosal damage --> inflammation and back flow of H+ into mucus layer

5

acute gastritis endoscopic findings

red, swollen mucosa with erosions/hemorrhages

6

Chronic Gastritis - general pathogenesis

chronic inflammation in lamina propria --> mucosal atrophy and intestinal metaplasia

various causes

7

autoimmune gastritis - pathogenesis and what this causes

autoantibodies against parietal cells (--> hypochlorhydria) and IF (-->pernicious anemia)

8

what part of the stomach is affected in autoimmune gastritis?

body and fundus

9

diffuse antral chronic gastritis - cause?

H pylori

10

what is seen with diffuse antral chronic gastritis?

lymphoid follicles - not normally present in stomach

11

zollinger-ellison syndrome

islet cell tumor of pancreas --> increase gastrin levels leads to parietal cell hyperplasia and high acid secretion --> ulcers

gastrin levels increase with secretin test