103b esophagus pathology Flashcards Preview

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Flashcards in 103b esophagus pathology Deck (22):
1

dyspagia

difficultly swallowing

2

odynophagia

painful swallowing

3

dyspepsia

indigestion

4

esophagus cell type and basal layer thickness

non-keratinized stratified squamous epithelium
15% (<50% for papilla)

5

where are glands and lympahtics located in the esophagus?

submucosa

6

what is the z line?

GE junction b/w columnar epithelium of stomach and non-keratinized statified squadmos epi of esophagus

7

which is darker staining in the esophagus - smooth or skeletal muscle?

skeletal is darker

8

reflux esophagitis definition

inflammatory process
reflux of gastric/dueodenal contents
failure of anti-reflux mechanisms (not belching or vomiting)

9

predisposing factors for RE
symptoms of PE

hiatus hernia
pyloric stenosis
increased intraabdominal P
symptoms - heart burn, painful swallowing, bleeding

10

RE pathogenesis and complications

low LES tone
increased gastic empting time
antral gastritis
complications - ulcers, strictures, barrett's esophagus

11

RE endoscopic findings

nothing 50% of time
hyperemia
white plaques from keratin formation

12

RE histo

basal cell hyperplasia
vascular papillae extension to surface
inflam. cels (PMNs, eosinophils)

13

Eosinophilic esophagitis morphology

>15 intraepithelial eosinophils in 2 or HPF
>25 in any HPF
lamina propria fibrosis

14

EoE presentation

majority have dysphagia with food getting stuck due to muscle dysfunction as a result of lamina propria fibrosis

15

EoE treatment

removal of allergic etiology
steroids

16

barrett's esophagus definition

replacement of nonkeratinized (stratified) squamous epithelium with intestinal (nonciliated columnar) epithelium and goblet cells in the distal esophagus

17

BE pathogenesis

GERD leads to ulcers which is replaced by stem cells turning into wrong type of cells

18

BE complications

adenocarcinoma (glandular differentiation) in the distal esophagus

19

what are the malignant cancers of the esophagus for the epithelium and mesenchyme

epi - adenocarcinoma and squamous cell carcinoma
mesen - leiomyosarcoma

20

what is the most common esophagus cancer in US? world? Where do these present?

US - adenocarcinoma (lower 1/3)
world - squamous cell (upper 2/3)

21

Plummer-vinson syndrome

long term iron deficiency
dysphagia due to web-like memrbanes in upper esophagus

22

tumor classification for esophagus

t1 = submucosa
t2 = muccularis propria
t3= adventitia
t4= adjacent structures