Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BOARD REVIEW > Breast > Flashcards

Breast Flashcards

1
Q

Risk factors of breast CA

A

Family Hx
Hx of prev breas Bx
Hx of LCIS on breast Bx (10x)
Hx of ADH on breast Bx (4x)
Early menarche
Late menopause
BRCA gene mutation

High risk patients may benefit from prophylactic Tamoxifen therapy (50%reduction at 5yrs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Chromosomes BRCA 1 and 2 genes located on

A

BRCA 1 - 13 — strong association w Ovarian CA
BRCA 2 - 17

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Route of matastasis for breast CA

A

Batson’s plexus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Her-2 (erb-2) positivity of breast tumor

A

Increase tumor aggresiveness
–tyrosine kinase for epidermal hrowth factor

HERCEPTIN (monoclonal antibody) - Beneficial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Herceptin (Trastuzumab) toxicity

A

Cardiac toxicity when combined w doxyrubicin and cyclophosphamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Role of p53 in breast CA

A

Mutation of the tumor suppressor gene results in unrestricted propagation of cells w/ mutated DNA (cancer cells)
– allows overexpression of apoptosis inhibiting oncogenes such as bcl-2 in breast CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Adverse effect of methylene blue and isosulfan

A

Isosulfan – cause allergic reaction w intraoperative hypotension

Methyline blue – cause skin necrosis if injected intradermally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

When should screening mammogram obtained?

A

Starts at age of 40 years every 1 to 2 years and annually after age 50 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Tender
Firm
Cord mass on lateral aspect of breast
Dx?
Tx?

A

Dx: mordor’s disease - thrombophlebitis of superficial vein on the breast
Tx: NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Definitive tx of DCIS in breast mass

A

Lupectomy + RT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Tx high grade DCIS in multiple quadrant of breast w/o any invasive carcinoma

A

Mastectomy w sentinel LN biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Sensory innervation of breast

A

Lateral and Anterior Cutaneous branches of 2nd through 6th intercoastal nerves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Location of Rotter’s node

A

Interpectorial region

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Tx for subareolar abscess in a 35yo

A

Needle aspiration
MC cause STAPHYLOCOCCUS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

LN located behind pectoralis minor muscle

A

Level II LN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Positive supraclavicular LN in breast cancer confer what stage?

A

Stage IIIC (former stage IV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

UTZ: disrupted tissue and fascial planes
Hyperechoic border to the mass
Displacement of surrounding breast tissue

A

Dx: Invasive breast CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Tumor markers negatively associated withoutcome in breast CA

A

ER (-)
PR (-)
Her-2 Nu (+)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Indication of ductography

A

Evaluation of bloody nipple discharge

20
Q

MC cause of bloody nipple discharge

A

Intraductal Papilloma

21
Q

Tx for mammary fistula w recurrent subareolar abscess

A

Probe-guided fistulectomy

22
Q

Initial diagnostic procedure with palpable breast mass

A

Fine needle aspiration (FNA)

23
Q

Current technique for localizing nonpalpable breast masses

A

Mammographic needle localization

24
Q

Treatment for hypercalcemia associated with metastatic breast CA

A

Calcitonin (inhibits osteoclast)
IV fluid
Lasix
Bisphosphonates (bind hydroxyapetite)

25
Q

Fungal infections affects the breast

A

Blastomycosis
Sporotrichosis

26
Q

Borders of formal axillary dissection

A

Latissimus dorsi
Chest wall
Axillary vein
Thoracodorsal nerve

27
Q

Nerve innervates the muscle responsible for arm ADDuction

A

Thoracodorsal nerve
Innervates Latissimus dorsi

28
Q

Nerve responsible for sensation of medial aspect of arm

A

Intercostobrachial

29
Q

Hypoplastic shoulder
Amastia
Absence of pectoralis muscle

A

Poland syndrome

30
Q

Management for Mordpr’s disease

A

Salicylates
Warm compress
Restriction of range of motion
Shoulder and brassiere support

31
Q

Side effects of Tamoxifen

A

Increase Endometrial CA
Increase DVT and cataracts
Inhibits p450 system – increase level of Coumadin
Ca channel blockers etc

32
Q

Ethiology of skin dimpling in women with breast CA

A

Glandular fibrosis and shortening of Cooper’s ligaments

33
Q

Perimenopausal woman
Palpable lumpiness beneath areola
Nipple discharge

A

Ductal ectasia

34
Q

Characteristic gross appearance of a fibroadenoma

A

Sharp circumscription w smooth boundaries and glistening, white cut surface

35
Q

Most frequently employed hornonal manipulation in patients with breast cancer

A

Estrogen blockade
(Tamoxifen - receptors;
Arimidex/Anastazole - synthesis)

36
Q

MC initial site of metastasis in breast CA

A

Bone

37
Q

Type of breast CA most frequently presents with palpable mass

A

Infiltrating ductal carcinoma

38
Q

Primary ductal CA presents with
Chronic, erythematous
Oozing
Eczematoid rash
Involving nipple and areola

A

Paget’s disease of the breast

39
Q

Tx for Inflammatory breast CA

A
  1. Chemotherapy
  2. Surgical excision and XRT

*Dermal lymphatic invasion of tumor cells on skin biopsy is diagnostic key for inflammatory breast CA

40
Q

MC primary sarcoma of breast

A

Cystosarcoma (phyllodes tumor)
Tx: wide excision w/o LN biopsy as sarcomas spread hematogenously

41
Q

Woman hx of ovarian CA has increased risk of breast CA
T/F

A

True

42
Q

Tx for patient w/ small localized phyllodes tumor

A

Local excision w/o LN biopsy

43
Q

Most important prognostic indicatir for recurrent breast CA and metastatic disease in women with breast cancer

A

Nodal status at time of initial dx

44
Q

Average age of diagnosis of invasive breast CA

A

60years

45
Q

Distinguishing feature of LCIS

A

Cytoplasmic mucoid globules

46
Q

MC complications of breast cancer radiation therapies

A

Skin erythema and desquamatikn
Lymphedema after axillary therapy

47
Q

Medical tx of radiation mastitis

A

Trenal (pentoxifylline)

BOARD REVIEW (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions