- Type 1 Von Willebrand Disease - hemophilia A or B

14 signs Flashcards by Bri deer

cachexia

B-thalassemia

-bc nutrients is stolen from tissues that are O2 starved for erythroid progenitors.

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hemosiderosis

hemolytic anemias (hereditary spherocytosis, G6PD, sicle cell, thalassemia, PNH, immunohemolytic anemias, d/t trauma)
=accumulation of hemosiderin (iron containing pigment) from RBC phagocytosis

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Intestinalization as parietal cells are replaced with mucus secreting goblet cells.

pernicious anemia

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Extremity vascular beds < 30°C can lead to obstruction → pallor, cyanosis and Raynaud’s.

Cold Agglutinin type of immunohemolytic anemia

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Easy bleeding and bruising.
Hematomas.
Bleeding into soft tissue and muscles.
Increased risk of bleeding during and after surgery.
Spontaneous hemorrhage in regions of the body normally subject to trauma (hemarthroses) that can lead to progressive, crippling deformities. Pts may have 1-2 target joints.
No petechiae.

hemophilia A or B

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IgG against RBCs previously sensatized to in blood transfused product

chronic hemolytic reaction from transfusion

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Increased HbA2

Nml HbF

Bthalassemia minor

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demyelination of dorsal and lateral spinal cord tracts

pernicious anemia

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pigment gall stones

hemolytic anemias (hereditary spherocytosis, G6PD, sicle cell, thalassemia, PNH, immunohemolytic anemias, d/t trauma)
-from eleveted bilirubin in the bile

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Anemia, hemoglobinemia, hemoglobinuria, hemosiderinuria, jaundice.

intravasc hemolysis –> hemolytic anemia

-so G6PD, PNH

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convulsions, coma

DIC

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stroke, retinal prbs, growth retardation

Sickle cell anemia

-from Microvascular occlusions of tissue

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fundic gland atrophy

pernicious anemia

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dilated, tortuous, thin-walled vessels.

Bleeding Disorder: Vessel Wall Abnormalities from Hereditary Hemorrhagic Telangiectasia (weber-osler-rendu Syndrome)

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pulmonary infiltrates

Transfusion-related Acute Lung Injury (TRALI)

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rapid splenic enlargement, hypovolemia and possible shock

sickle cell anemia: sequestration crisis

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Microcytosis with minimal anemia and no abnormal physical s/s

a thalassemia trait: Trans deletion

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PTT prolonged

Type 1 Von Willebrand Disease

- hemophilia A or B

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priapism

sickle cell anemia: pain crisis (vasculoocclusive dis)

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Massive erythroid hyperplasia and extramedullary erythropoiesis.

Sickle cell anemia

- B thalassemia major

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atrophic glossitis

pernicious anemia

=beefy red tongue

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HTN, obese, anxious pts

Gaisbock syndrome (stress polycythemia): a relative polycythemia

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rapid thrombocytopenia after starting heparin

Type 1 heparin-induced thrombocytopenia

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mild erythroid hyperlasia

Bthalassemia minor

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platelet count nml

Bleeding Disorder: Vessel Wall Abnormalities

HSM

B thalassemia major

dyspnea, cyanosis, resp failure

DIC

normoblasts in bm (erythroid precursors)

hemolytic anemias (hereditary spherocytosis, G6PD, sicle cell, thalassemia, PNH, immunohemolytic anemias, d/t trauma)

IgM against RBCs blood transfused product

acute hemolytic reaction from transfusion

Severe pallor, generalized edema and massive HSM in utero

a thalassemia: hydrops fetalis= 4 deletions

fever, HoTN, hypoxia

Transfusion-related Acute Lung Injury (TRALI)

Pancytopenia

- megaloblastic anemia | - aplastic anemia

hyposthenuria

sickle cell anemia | =hypertonicity renal medulla --> not conc urine

elevated EPO

hemolytic anemias (hereditary spherocytosis, G6PD, sicle cell, thalassemia, PNH, immunohemolytic anemias, d/t trauma)

Infections of encapsulated bugs. | --S. Typhi osteomyelitis, S. Pneumoniae and H. Influenzae.

sickle cell anemia

Retinopathy: loss of visual acuity --> blindness

sickle cell anemia: pain crisis (vasculoocclusive dis)

increased RDW and MCHC

hereditary spherocytosis (HS)

dehydration, acidemia, deoxygenation

sickle cell anemia: acute chest synd of pain crisis (vasculoocclusive dis)

reticulocytes in PB

hemolytic anemias (hereditary spherocytosis, G6PD, sicle cell, thalassemia, PNH, immunohemolytic anemias, d/t trauma)

IgG recognize IgA in blood transfused product

=> allergic rxn

tissue hypoxia disproportionate to the level of Hb.

a thalassemia: Hemoglobin H disease (HBH)= 3 deletions

hemosiderinuria

Paroxysmal Nocturnal Hemoglobinuria (PNH) | → iron deficiency that can exacerbate the anemia

Increased HbF

B thalassemia major

PT, PTT nml

- Bleeding Disorder: Vessel Wall Abnormalities | - bleeding from thrombocytopenia

IgE recognize IgA in blood transfused product

=> allergic rxn --> urticarial reaction

secondary hemochromatosis

B-thalassemia - bc Excessive absorption of dietary iron d/t suppressed hepcidin and in combination with repeat transfusions - -> affect <3, liver, panc

have other AI disorders: thyroiditis, adrenalitis

pernicious anemia

crewcut skull and chipmonk facies

- Sickle cell anemia from new bone deposition d/t BM expansion - B-thatlssemia

incrased homocystiene

pernicious anemia | folate deficiency

abn bleeding/petechiae/echmosis

aplastic anemia from thrombocytopenia

Oliguria and acute renal failure

DIC

Purpuric rash, abdominal pain, polyarthralgia and acute glomerulonephritis

Bleeding Disorder: Vessel Wall Abnormalities from | Henoch-schonlein Purpura

Atrophic changes in the tongue and gastric mucosa

Iron deficiency anemia

- Microcytic, hypochromic anemia. - Atrophic glossitis. - Esophageal webs.

Plummer-vinson Syndrome

- ischemia - Microangiopathic hemolytic anemia - hem diasthesis

DIC

leg ulcers

Sickle cell anemia | -from Vascular stagnation of subq tissue

impaired bone grth and skeletal abns

B-thalassemia

renal hemosiderosis

intravasc hemolysis --> hemolytic anemia = Fe accumulation in tubular cells -so G6PD, PNH

mucocutaneous bac infection

aplastic anemia from granulocytopenia

thrombosis and thrombocytopenia 5-14d after starting heparin

Type 2 heparin-induced thrombocytopenia

o Hypoplasia of the kidney or spleen. | o Bone anomalies of the thumbs or radii

fanconi anemia

Hb degradation products

hemolytic anemias (hereditary spherocytosis, G6PD, sicle cell, thalassemia, PNH, immunohemolytic anemias, d/t trauma)

stroke

sickle cell anemia: pain crisis (vasculoocclusive dis)

low EPO, TIBC, Iron

anemia of chronic dis

NO splenomegaly

aplastic anemia

Intestinal malabsorption

Iron deficiency anemia

markedly reduced haptoglobin

intravasc hemolysis --> hemolytic anemia | -so G6PD, PNH

anemia, splenomegaly, jaundice

extravasc hemolysis --> hemolytic anemia | -so hereditary spherocytosis (HS), SCA, B-thalassemai, AI HA

Circulatory failure and shock.

DIC

- Fever - Thrombocytopenia - Microangiopathic hemolytic anemia - Transient neuro deficits - Renal failure

Thrombotic Thrombocytopenic Purpura (TTP), if these EXCEPT neuro defect = Hemolytic Uremic Syndrome (HUS)

14 signs Flashcards

(70 cards)