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signs Flashcards

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1
Q

Leukoerythroblastosis: Premature release of nucleated erythroid and early granulocyte precursors.

A

Primary Myelofibrosis (PM)

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2
Q

Graves disease, SLE, scleroderma, RA, and other AI disorders

A

thymic (follicular hyperplasia)

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3
Q

thymic/mediastinal mass

A

t- ALL (tcell acute lymphoblastic leukemia)

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4
Q

pulmonary lesions and destructive osteolytic bone lesions

A

-Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)

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5
Q

localized soft-tissue mass (myeloblastoma, granulocytic sarcoma/chloroma

A

AML

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6
Q

abs to GPIIb/IIIa, vWF

A

AML, NOS, M7

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7
Q

IgG and/or light chains (k) in urine and plasma

A 
multiple myeloma (plasma cell myeloma) 
-bence jones proteinurua
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8
Q

demyelinating dis of CNS

A

Adult T-cell Leukemia/Lymphoma

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9
Q

increased LFTs, TGs

A

Hemophagocytic Lymphohistocytosis (HLH)

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10
Q

normocytic, normochromic anemia +/- moderate leukopenia and thrombocytopenia.

A

multiple myeloma (plasma cell myeloma)

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11
Q

Thrombosis and hemorrhage d/t platelet dysfunction and increased number.
o DVT, portal and hepatic v. thrombosis, MI

A

-Polycythemia Vera (PCV or PV)
-Essential Thrombocytosis (ET)
Primary Myelofibrosis (PM)

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12
Q

RA, splenomegaly, neutropenia

A

Large Granular Lymphocytic Leukemia: felty synd

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13
Q

puritis

A

Polycythemia Vera (PCV or PV)

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14
Q

anemia

A
  • Hemophagocytic Lymphohistocytosis (HLH)
  • C/SLL (chronics,small lymphocytic leukemia) (from neoplastic Bcell autoabs)
  • Large Granular Lymphocytic Leukemia
  • AML
  • Primary Myelofibrosis (PM)
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15
Q

peptic ulcers

A

Polycythemia Vera (PCV or PV)

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16
Q

LNs enlarged, tender, fluctuant (moveable), and may form abscesses; red overlying skin

A

Acute Nonspecific Lymphadenitis

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17
Q

moth eaten vertebral column, ribs, skull, pelvis, femur, calvicle, scapula

A

multiple myeloma (plasma cell myeloma)

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18
Q

Mass of mandible/face and/or abdominal viscera (kidneys, ovaries, adrenals).

A

African (endemic) burkitt lymphoma

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19
Q

HepatoMegaly

A
  • Hemophagocytic Lymphohistocytosis (HLH)
  • C/SLL (chronics,small lymphocytic leukemia)
  • lymphoplasmacytic lymphoma
  • mamntle cell lymphoma (MCL)
  • Adult T-cell Leukemia/Lymphoma
  • AML, NOS, M5
  • Chronic Myelogenous Leukemia (CML)
  • spent phase of Polycythemia Vera (PCV or PV)
  • Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)
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20
Q

spontaneous mucosal and cutaneous bleeding (gingiva, urinary tract); cutaneous petechiae and ecchymoses

A

AML

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21
Q

erythromelaglia

A 
Essential Thrombocytosis (ET)
=arteriole occlusion by platelet aggregates → burning and throbbing of hands and feet.
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22
Q

opportunistic infections of oral cavity, skin, lungs, kidneys, bladder, colon (fungi, Pseudomonas, commensals).

A

AML

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23
Q

PB:incrased megakaryocytes, platelses

A

Chronic Myelogenous Leukemia (CML)

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24
Q

PAS+

A

ALL (acute lymphoblastic leukemia)- d/t the lymphoblasts

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25
seablue histiocytes
Chronic Myelogenous Leukemia (CML) | =mfs w wrinkled green-blue cyto
26
down synd
AML, NOS, M7
27
hypoparathyroidism and defects in cell-mediated immuity
DiGeorge synd: thymic hypoplasia/aplasia
28
neutropenia
- Large Granular Lymphocytic Leukemia | - AML
29
thrombocytopenia
- Hemophagocytic Lymphohistocytosis (HLH) - C/SLL (chronics,small lymphocytic leukemia)(from neoplastic Bcell autoabs) - AML (
30
Lymphomatoid polyposis: if mucosal involvement of the small bowel or colon → polyps (can be misdiagnosed as ulcerative colitis).
mantle cell lymphoma (MCL)
31
Leukocyte alkaline phosphatase (LAP) is high
reactive states, like infxn - worried about CML
32
hyperCa
multiple myeloma (plasma cell myeloma)
33
+ prussian blue stain
Myelodysplastic syndromes (MDS) (erythroid lineage: ring sideroblasts)
34
hemophagocytosis on BM esam
Hemophagocytic Lymphohistocytosis (HLH)
35
elevated platelets w/o polycythemia of marrow fibrosis
Essential Thrombocytosis (ET)
36
mass of iliocecum an peritoneum
sporadic burkitt lymphoma
37
Leukocytosis, exceeding 100,000 cells/mm^3
Chronic Myelogenous Leukemia (CML)
38
Anemia, thrombocytopenia, recurrent infections (otitis media, mastoiditis)
-Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)
39
MPO-
ALL (acute lymphoblastic leukemia) - d/t the lymphobalsts
40
hyperuricemia/gout
- Polycythemia Vera (PCV or PV) | - Primary Myelofibrosis (PM)
41
iron deficiency
Polycythemia Vera (PCV or PV)
42
increased blood viscosity and sludging
Polycythemia Vera (PCV or PV)
43
Hand-schuller-christian Triad:
Multifocal Unisystem Langerhans Cell Histiocytosis | =Calvarial bone defects, DI, exopthalmos (scalp rash).
44
- Multiple erosive bone masses. - May extend into soft tissue. - May involve posterior pituitary stalk = diabetes insipidus (50%)
Multifocal Unisystem Langerhans Cell Histiocytosis
45
Blasts are < 10% of circulating cells.
Chronic Myelogenous Leukemia (CML)
46
if have sinus histiocytes...
look for CA (carcinoma of breats)
47
look like appendicitis
mesenteric Acute Nonspecific Lymphadenitis
48
paraneoplastic syndromes may be dx (hypogammaglobulinemia, pure red cell aplasia, Graves dis, pernicious anemia, dermatomyositis-polymyositis, Cushings)
thymoma
49
rheumatoid disorders
-Large Granular Lymphocytic Leukemia
50
skin lesions, peripheral blood lymphocytosis, hypercalcemia
Adult T-cell Leukemia/Lymphoma
51
splenomegaly
- Hemophagocytic Lymphohistocytosis (HLH) - t- ALL (tcell acute lymphoblastic leukemia)- d/t the lymphoblasts - C/SLL (chronics,small lymphocytic leukemia) - lymphoplasmacytic lymphoma - mamntle cell lymphoma (MCL) - hairy cell leukemia ((MASSIVE)) - Adult T-cell Leukemia/Lymphoma - Large Granular Lymphocytic Leukemia - AML, NOS, M5 - Chronic Myelogenous Leukemia (CML) - spent phase of Polycythemia Vera (PCV or PV) - massive - Primary Myelofibrosis (PM) - Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)
52
Leukocyte alkaline phosphatase (LAP) is low
Chronic Myelogenous Leukemia (CML)
53
LAD
- t- ALL ( tcell acute lymphoblastic leukemia)- d/t the lymphoblasts - C/SLL (chronics,small lymphocytic leukemia) - follicular lymphoma - lymphoplasmacytic lymphoma - mamntle cell lymphoma (MCL) - Peripheral T-cell Lymphoma, Unspecified - Adult T-cell Leukemia/Lymphoma - all HL, generally painless LAD - Hodgkin Lymphoma: Lymphocyte Predominance Subtype - AML, NOS, M5 - Chronic Myelogenous Leukemia (CML) - Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)
54
solitary lesion of bone/st
solitary myeloma (plasmocytoma)
55
pancytopenia
-hairy cell leukemia
56
many bac infections
- C/SLL (chronics,small lymphocytic leukemia) (d/t hypogammaglobulinemia) - multiple myeloma (plasma cell myeloma) (but not viral infections) - Primary Myelofibrosis (PM)
57
kid with low platelet count
ALL (acute lymphoblastic leukemia) ... until proven otherwise
58
renal failure
multiple myeloma (plasma cell myeloma)
59
decreased EPO
Polycythemia Vera (PCV or PV)
60
high Hct basophila lg platlets
Polycythemia Vera (PCV or PV)
61
rituculin
- AML, NOS, M7 | - Chronic Myelogenous Leukemia (CML)
62
waldeyer ring involvement
DLBCL (diffuse large B cell lymphoma)
63
puritis, eosinophilia, fever, wt loss
Peripheral T-cell Lymphoma, Unspecified
64
diffuse demineralization (osteopenia)
multiple myeloma (plasma cell myeloma)
65
organomegaly
- Polycythemia Vera (PCV or PV) | - Essential Thrombocytosis (ET)

heme/lymph (18 decks)

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